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TargetMicrotubule-associated protein tau(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340902((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataEC50:  5.50E+3nMAssay Description:Inhibition of tau protein phosphorylation at Ser396 in rat brain cells at 0.5 to 50 uM after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340908((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(3-meth...)
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340911((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(3-fluo...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340902((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 25nMAssay Description:Inhibition of CDK2 in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340902((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340893((4-amino-2-(3-aminophenylamino)thiazol-5-yl)(3-flu...)
Affinity DataIC50: 31nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340896((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(3-fluo...)
Affinity DataIC50: 33nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340897((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 38nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340894((4-amino-2-(3-(methylamino)phenylamino)thiazol-5-y...)
Affinity DataIC50: 44nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340902((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 45nMAssay Description:Inhibition of GSK3-beta in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340913((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(2-meth...)
Affinity DataIC50: 60nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340903((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(3-fluo...)
Affinity DataIC50: 62nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340895((4-amino-2-(4-(dimethylamino)phenylamino)thiazol-5...)
Affinity DataIC50: 68nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340899((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(2-meth...)
Affinity DataIC50: 80nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340884((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(pyridi...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340906((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(3-nitr...)
Affinity DataIC50: 130nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340887((4-amino-2-(6-(trifluoromethyl)pyridin-3-ylamino)t...)
Affinity DataIC50: 160nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5/P25 using full length tau as substrate by colorimetric ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340914((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(3-meth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 270nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340905((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(phenyl...)
Affinity DataIC50: 341nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340910((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 360nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340912((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(4-fluo...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340900((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(3-meth...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340907((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-meth...)
Affinity DataIC50: 418nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340891((4-amino-2-(piperidin-3-ylamino)thiazol-5-yl)(3-fl...)
Affinity DataIC50: 500nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340882((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(4-meth...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM50155420(Xanthen-9-one, 1.1 | 1,5,8-Trihydroxy-3-methoxy-xa...)
Affinity DataIC50: 700nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340889((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-fl...)
Affinity DataIC50: 700nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59195(4-aminothiazole, 2.1)
Affinity DataIC50: 700nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340888((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-ni...)
Affinity DataIC50: 750nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340883((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(pyridi...)
Affinity DataIC50: 800nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340901((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(4-meth...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340898((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(4-fluo...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340885((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(pyridi...)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340888((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-ni...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK5/P25 using full length tau as substrate by colorimetric ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59201(2,3-dihydro-1H-4-oxa-2,5-diazaphenanthrenes, 3.2)
Affinity DataIC50: 2.30E+3nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340909((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(4-meth...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340890((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-me...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340904((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(4-fluo...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340892((4-amino-2-(piperidin-4-ylamino)thiazol-5-yl)(3-fl...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59200(2,3-dihydro-1H-4-oxa-2,5-diazaphenanthrenes, 3.1)
Affinity DataIC50: 6.70E+3nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340886((2-fluorophenyl)(4-(methylamino)-2-(pyridin-3-ylam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59199(2,3-dihydro-1H-4-oxa-2,5-diazaphenanthrenes, 3.0)
Affinity DataIC50: 1.70E+4nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM50155436(Xanthen-9-one, 1.4 | CHEMBL365234 | 1,3,5-Trihydro...)
Affinity DataIC50: 2.60E+4nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59196(4-aminothiazole, 2.2)
Affinity DataIC50: 3.80E+4nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59197(4-aminothiazole, 2.3)
Affinity DataIC50: 6.60E+4nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59198(4-aminothiazole, 2.4)
Affinity DataIC50: 1.00E+5nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59192(Xanthen-9-one, 1.3)
Affinity DataIC50: 2.47E+5nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59191(Xanthen-9-one, 1.2)
Affinity DataIC50: 5.33E+5nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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