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TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543779(CHEMBL4635767)
Affinity DataKd:  230nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  49nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543779(CHEMBL4635767)
Affinity DataKd:  230nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316305(((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...)
Affinity DataKd:  460nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543775(CHEMBL4640985)
Affinity DataKd:  17.7nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543773(CHEMBL4636472)
Affinity DataKd:  302nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543780(CHEMBL4646578)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543777(CHEMBL4632744)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543774(CHEMBL4640855)
Affinity DataKd:  344nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543776(CHEMBL4647306)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316304(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  2.00E+3nMAssay Description:Inhibition of fluorescein-labeled m7GDPC4H5 binding to mouse eIF4E (28 to 217 residues) by MST methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316304(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  1.24E+3nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543777(CHEMBL4632744)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543775(CHEMBL4640985)
Affinity DataKd:  18nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50452630(CHEMBL4203412)
Affinity DataKd:  5.90E+3nMAssay Description:Inhibition of fluorescein-labeled m7GDPC4H5 binding to mouse eIF4E (28 to 217 residues) by MST methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543778(CHEMBL4640425)
Affinity DataKd:  570nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  70nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543775(CHEMBL4640985)
Affinity DataIC50: 280nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte lysate system assessed as reduction in ARCA mRNA cap-dependent translation measured after 60 mins by lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543775(CHEMBL4640985)
Affinity DataIC50: 280nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte lysate system assessed as reduction in ARCA mRNA cap-dependent translation measured after 60 mins by lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294223(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Affinity DataIC50: 560nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110843(CHEMBL3604542)
Affinity DataIC50: 560nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110843(CHEMBL3604542)
Affinity DataIC50: 560nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294223(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Affinity DataIC50: 560nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294221(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110892(CHEMBL3604537)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294221(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110895(CHEMBL3604540)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110892(CHEMBL3604537)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294223(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110844(CHEMBL3604543)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543774(CHEMBL4640855)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte lysate system assessed as reduction in ARCA mRNA cap-dependent translation measured after 60 mins by lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294223(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110844(CHEMBL3604543)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110895(CHEMBL3604540)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Targetm7GpppX diphosphatase(Human)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human DCPS using m7GMPF as substrate after 30 mins by nucleoside 5'-fluorophosphate probe based HTS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294221(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316302(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110894(CHEMBL3604539)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110896(CHEMBL3604541)
Affinity DataIC50: 2.61E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50365099(CHEMBL1951197)
Affinity DataIC50: 2.62E+3nMAssay Description:Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte lysate system assessed as reduction in ARCA mRNA cap-dependent translation measured after 60 mins by lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110893(CHEMBL3604538)
Affinity DataIC50: 3.22E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110894(CHEMBL3604539)
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110891(CHEMBL3604536)
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50365100(CHEMBL1951195)
Affinity DataIC50: 3.52E+3nMAssay Description:Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50365099(CHEMBL1951197)
Affinity DataIC50: 3.58E+3nMAssay Description:Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110896(CHEMBL3604541)
Affinity DataIC50: 3.68E+3nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50365101(CHEMBL1951193)
Affinity DataIC50: 3.74E+3nMAssay Description:Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294221(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50365101(CHEMBL1951193)
Affinity DataIC50: 3.97E+3nMAssay Description:Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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