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TargetGlutamate receptor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Agonist activity at human GluA2(Q)i expressed in HEK293 cells assessed as enhancement of glutamate-evoked desensitized current by whole cell patch cl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50493768(CHEMBL2441072)
Affinity DataEC50:  2.25E+4nMAssay Description:Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by FLIPR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50032241(CHEMBL2441067)
Affinity DataEC50:  900nMAssay Description:Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50457619(CHEMBL2441066)
Affinity DataEC50:  4.17E+3nMAssay Description:Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50493769(CHEMBL2441068)
Affinity DataEC50:  3.13E+3nMAssay Description:Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50493770(CHEMBL2441073)
Affinity DataEC50:  2.50E+3nMAssay Description:Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50493771(CHEMBL2441069)
Affinity DataEC50:  4.83E+3nMAssay Description:Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142614(CHEMBL3758336)
Affinity DataIC50: 3.70E+3nMAssay Description:Antagonist activity against recombinant rat GluA2(Q)i expressed in xenopus oocytes assessed as inhibition of L-glutamate-induced intracellular calciu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142618(CHEMBL3759959)
Affinity DataIC50: 6.30E+3nMAssay Description:Antagonist activity against recombinant rat GluA2(Q)i expressed in xenopus oocytes assessed as inhibition of L-glutamate-induced intracellular calciu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50088453(CHEMBL72433 | NS3570, 5 | 1-(6-bromo-5-ethoxypyrid...)
Affinity DataKi:  0.0670nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  0.0970nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50088453(CHEMBL72433 | NS3570, 5 | 1-(6-bromo-5-ethoxypyrid...)
Affinity DataKi:  0.25nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50088454(NS3920, 4 | CHEMBL306387 | 1-(6-bromopyridin-3-yl)...)
Affinity DataKi:  0.320nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  0.330nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM92377(NS3573, 2)
Affinity DataKi:  0.620nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50088438(CHEMBL71085 | 1-Pyridin-3-yl-[1,4]diazepane | NS35...)
Affinity DataKi:  0.720nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50088437(CHEMBL303889 | NS3570, 3 | 1-(5-Phenyl-pyridin-3-y...)
Affinity DataKi:  0.800nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM86311(CAS_485-35-8 | NSC_22407 | Cytisine | Cytisine-(-)...)
Affinity DataKi:  0.950nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50088454(NS3920, 4 | CHEMBL306387 | 1-(6-bromopyridin-3-yl)...)
Affinity DataKi:  1.30nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM92377(NS3573, 2)
Affinity DataKi:  2.20nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50088438(CHEMBL71085 | 1-Pyridin-3-yl-[1,4]diazepane | NS35...)
Affinity DataKi:  3.10nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  6nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM86311(CAS_485-35-8 | NSC_22407 | Cytisine | Cytisine-(-)...)
Affinity DataKi:  8.20nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50088437(CHEMBL303889 | NS3570, 3 | 1-(5-Phenyl-pyridin-3-y...)
Affinity DataKi:  8.90nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  18nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  83nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50088438(CHEMBL71085 | 1-Pyridin-3-yl-[1,4]diazepane | NS35...)
Affinity DataKi:  136nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  170nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50088454(NS3920, 4 | CHEMBL306387 | 1-(6-bromopyridin-3-yl)...)
Affinity DataKi:  190nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM86311(CAS_485-35-8 | NSC_22407 | Cytisine | Cytisine-(-)...)
Affinity DataKi:  295nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50088453(CHEMBL72433 | NS3570, 5 | 1-(6-bromo-5-ethoxypyrid...)
Affinity DataKi:  847nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142614(CHEMBL3758336)
Affinity DataKi:  1.74E+3nMAssay Description:Displacement of [3H]AMPA from full length rat cloned GluA2(R)o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142614(CHEMBL3758336)
Affinity DataKi:  2.26E+3nMAssay Description:Displacement of [3H]AMPA from GluA2 LBD (unknown origin) incubated for 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50304101((RS)-2-Amino-3-(5,6-dichloro-3'-hydroxybiphenyl-3-...)
Affinity DataKi:  5.03E+3nMAssay Description:Displacement of [3H]AMPA from full length rat cloned GluA2(R)o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142614(CHEMBL3758336)
Affinity DataKi:  6.65E+3nMAssay Description:Displacement of [3H]AMPA from rat cloned GluA1o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142614(CHEMBL3758336)
Affinity DataKi:  6.88E+3nMAssay Description:Displacement of [3H]AMPA from rat cloned GluA3o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM92377(NS3573, 2)
Affinity DataKi:  9.97E+3nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50088437(CHEMBL303889 | NS3570, 3 | 1-(5-Phenyl-pyridin-3-y...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50304101((RS)-2-Amino-3-(5,6-dichloro-3'-hydroxybiphenyl-3-...)
Affinity DataKi:  1.71E+4nMAssay Description:Displacement of [3H]AMPA from rat cloned GluA1o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142618(CHEMBL3759959)
Affinity DataKi:  2.40E+4nMAssay Description:Displacement of [3H]AMPA from full length rat cloned GluA2(R)o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142618(CHEMBL3759959)
Affinity DataKi:  3.96E+4nMAssay Description:Displacement of [3H]SYM2081 from cloned rat GluK3A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142604(CHEMBL3759334)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142616(CHEMBL3759154)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142603(CHEMBL3759469)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142608(CHEMBL3759809)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142609(CHEMBL3759138)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142607(CHEMBL3759390)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142610(CHEMBL3759124)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142611(CHEMBL3759856)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50142606(CHEMBL3758252)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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