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TargetPlasminogen activator inhibitor 1(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275([{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol...)
Affinity DataKd:  480nMAssay Description:Binding affinity to towards NBD-labeled S119C Plasminogen activator inhibitor-1 mutant in ratMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasminogen activator inhibitor 1(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275([{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity of compound towards latent Plasminogen activator inhibitor-1 expressed as apparent KdMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin beta-1 chain(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150589(CHEMBL182319 | 4-{[3,3-Dimethyl-2-(3-methyl-2-meth...)
Affinity DataKd:  260nMAssay Description:Binding affinity towards tubulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin beta-1 chain(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152133(4-{[3,3-Dimethyl-2-(3-methyl-2-methylamino-3-pheny...)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity towards tubulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin beta-1 chain(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152123(4-({2-[3-(4-Methoxy-phenyl)-3-methyl-2-methylamino...)
Affinity DataKd:  700nMAssay Description:Binding affinity towards tubulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin beta-1 chain(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152118(4-[(2-{2-[(2-Hydroxy-ethyl)-methyl-amino]-3-methyl...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity towards tubulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin beta-1 chain(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152105(Ethyl-(S)-N,beta,beta-Trimethylphenylalanyl-(S)-te...)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity towards tubulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin beta-1 chain(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50152135(4-{[2-(3-Cyclohexyl-3-methyl-2-methylamino-butyryl...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity towards tubulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTubulin beta-1 chain(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150585(2,5-Dimethyl-4-{methyl-[3-methyl-2-(3-methyl-2-met...)
Affinity DataKd:  700nMAssay Description:Binding affinity towards tubulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50247135(2-methyl-N-phenethyl-5-(phenylsulfonyl)benzenesulf...)
Affinity DataEC50:  3.88E+3nMAssay Description:Inhibition of human sFRP1 expressed in human U2OS assessed as luciferase activity by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50246651(N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-ethyl-5-(phenyl...)
Affinity DataEC50:  6.97E+3nMAssay Description:Inhibition of human sFRP1 expressed in human U2OS assessed as luciferase activity by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50246617(2-Ethyl-5-(phenylsulfonyl)-N-(3-pyrrolidin-1-ylpro...)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of human sFRP1 expressed in human U2OS assessed as luciferase activity by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50246616(N-[3-(Dimethylamino)propyl]-2-ethyl-5-(phenylsulfo...)
Affinity DataEC50:  1.27E+3nMAssay Description:Inhibition of human sFRP1 expressed in human U2OS assessed as luciferase activity by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50247135(2-methyl-N-phenethyl-5-(phenylsulfonyl)benzenesulf...)
Affinity DataKd:  350nMAssay Description:Binding affinity to human sFRP1 by fluorescence spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265480(N-[1-(Morpholin-4-ylacetyl)piperidin-4-yl]-5-(phen...)
Affinity DataEC50:  160nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265481(5-(Phenylsulfonyl)-N-[1-(piperazin-1-ylacetyl)pipe...)
Affinity DataEC50:  250nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265499(N-[1-(1H-Imidazol-1-ylacetyl)piperidin-4-yl]-5-(ph...)
Affinity DataEC50:  230nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265500(tert-Butyl (2S)-2-{[4-({[5-(Phenylsulfonyl)-2-(tri...)
Affinity DataEC50:  60nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265501(tert-Butyl (2R)-2-{[4-({[5-(Phenylsulfonyl)-2-(tri...)
Affinity DataEC50:  210nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265502(tert-Butyl(5S)-2-oxo-5-{[4-({[5-(Phenylsulfonyl)-2...)
Affinity DataEC50:  90nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265503(5-(Phenylsulfonyl)-N-(1-L-prolylpiperidin-4-yl)-2-...)
Affinity DataEC50:  350nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265504((R)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbony...)
Affinity DataEC50:  710nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265505(N-[1-(5-oxo-L-Prolyl)piperidin-4-yl]-5-(phenylsulf...)
Affinity DataEC50:  240nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265544(N-[1-(1-Acetyl-L-prolyl)piperidin-4-yl]-5-(phenyls...)
Affinity DataEC50:  250nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265545(N-[1-(1-Isobutyryl-L-prolyl)piperidin-4-yl]-5-(phe...)
Affinity DataEC50:  90nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265546(N-{1-[1-(2,2-Dimethylpropanoyl)-L-prolyl]piperidin...)
Affinity DataEC50:  270nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265547(N-{1-[1-(3,3-Dimethylbutanoyl)-L-prolyl]piperidin-...)
Affinity DataEC50:  120nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265548(N-[1-(N,N-Dimethylglycyl-L-prolyl)piperidin-4-yl]-...)
Affinity DataEC50:  310nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265549(N-{1-[1-(Cyclohexylcarbonyl)-L-prolyl]piperidin-4-...)
Affinity DataEC50:  460nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265550(N-[1-(1-Benzoyl-L-prolyl)piperidin-4-yl]-5-(phenyl...)
Affinity DataEC50:  380nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265551(N-(1-{1-[4-(Dimethylamino)benzoyl]-L-prolyl}piperi...)
Affinity DataEC50:  830nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265552(N-[1-(1-Isonicotinoyl-L-prolyl)piperidin-4-yl]-5-(...)
Affinity DataEC50:  350nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265553((2S)-N-Ethyl-2-{[4-({[5-(phenylsulfonyl)-2-(triflu...)
Affinity DataEC50:  90nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265554((2S)-N-(tert-Butyl)-2-{[4-({[5-(phenylsulfonyl)-2-...)
Affinity DataEC50:  30nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265555((2S)-N-Phenyl-2-{[4-({[5-(phenylsulfonyl)-2-(trifl...)
Affinity DataEC50:  310nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265580((2S)-N,N-Dimethyl-2-{[4-({[5-(phenylsulfonyl)-2-(t...)
Affinity DataEC50:  160nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265581(N-{1-[1-(Morpholin-4-ylcarbonyl)-L-prolyl]piperidi...)
Affinity DataEC50:  280nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265582(N-[1-(1-Methyl-L-prolyl)piperidin-4-yl]-5-(phenyls...)
Affinity DataEC50:  230nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265583(N-{1-[1-(3,3-Dimethylbutyl)-L-prolyl]piperidin-4-y...)
Affinity DataEC50:  450nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265584(N-{1-[1-(Cyclohexylmethyl)-L-prolyl]piperidin-4-yl...)
Affinity DataEC50:  320nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265585(N-[1-(1-Benzyl-L-prolyl)piperidin-4-yl]-5-(phenyls...)
Affinity DataEC50:  720nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265467(5-(Phenylsulfonyl)-N-piperidin-4-yl-2-(trifluorome...)
Affinity DataEC50:  650nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265468(N-[1-(N-Methylglycyl)piperidin-4-yl]-5-(phenylsulf...)
Affinity DataEC50:  620nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265469(N-[1-(N,N-Dimethylglycyl)piperidin-4-yl]-5-(phenyl...)
Affinity DataEC50:  280nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265479(5-(Phenylsulfonyl)-N-[1-(pyrrolidin-1-ylacetyl)pip...)
Affinity DataEC50:  190nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302906(methyl 2-(2-(2-imino-4-oxothiazolidin-5-yl)acetami...)
Affinity DataEC50:  7.20E+3nMAssay Description:Inhibition of human SFRP1 transfected in human U20S cells by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302906(methyl 2-(2-(2-imino-4-oxothiazolidin-5-yl)acetami...)
Affinity DataKd:  720nMAssay Description:Binding affinity to human SFRP1 by fluorescence spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308681(N-(1-Benzoylpiperidin-4-yl)-5-(phenylsulfonyl)-2-t...)
Affinity DataEC50:  250nMAssay Description:Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308682(N-[1-(2-Chlorobenzoyl)piperidin-4-yl]-5-(phenylsul...)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308683(N-[1-(3-Chlorobenzoyl)piperidin-4-yl]-5-(phenylsul...)
Affinity DataEC50:  870nMAssay Description:Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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