Compile Data Set for Download or QSAR
Found 608 with Last Name = 'kung' and Initial = 'hf'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50154364((6R,10bS)-6-(4-Methylsulfanyl-phenyl)-1,2,3,5,6,10...)
Affinity DataKi:  0.00900nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(2-(2-((dimethylamino)methyl)phenylthio)-5-iodoanil...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(2-(2-((dimethylamino)methyl)phenylthio)-5-iodoanil...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of [125I]IPT uptake at SERT (unknown origin) expressed in LLC-PK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM81987(CHEMBL116048 | McN-5652-15)
Affinity DataKi:  0.0100nMAssay Description:In vitro binding affinity of the compound against Serotonin transporter (SERT) from LLC-PK1 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(2-(2-((dimethylamino)methyl)phenylthio)-5-iodoanil...)
Affinity DataKi:  0.0130nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(2-(2-((dimethylamino)methyl)phenylthio)-5-iodoanil...)
Affinity DataKi:  0.0130nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.0150nMAssay Description:Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50040079(CHEMBL308524 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2...)
Affinity DataKi:  0.0190nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50008785(CHEMBL42953 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.0250nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50425189(CHEMBL2314217)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of [125I]IDAM uptake at SERT (unknown origin) expressed in LLC-PK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228440(5-chloro-2-(2-((dimethylamino)methyl)-4-(2-fluoroe...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50062262(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  0.0450nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119550(5-Chloro-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi:  0.0500nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228439(5-bromo-2-(2-((dimethylamino)methyl)-4-(2-fluoroet...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50062268(6-Iodo-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...)
Affinity DataKi:  0.0690nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50062268(6-Iodo-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...)
Affinity DataKi:  0.0690nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50425187(CHEMBL2314215)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012965(5-Iodo-2,3-dihydro-benzofuran-7-carboxylic acid (1...)
Affinity DataKi:  0.0850nMAssay Description:Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007518((S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)me...)
Affinity DataKi:  0.0900nMAssay Description:Compound was evaluated for the inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.0970nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.0970nMAssay Description:In vitro binding affinity of the compound against Serotonin transporter (SERT) from LLC-PK1 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.0970nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of [125I]IPT uptake at SERT (unknown origin) expressed in LLC-PK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228444(2-(2-((dimethylamino)methyl)-4-(2-fluoroethoxy)phe...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to VMAT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50040077(5-Iodo-2,3-dihydro-benzofuran-7-carboxylic acid [1...)
Affinity DataKi:  0.106nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101410((trans,trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50154366(CHEMBL183470 | [2-(2-Dimethylaminomethyl-phenoxy)-...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101411(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi:  0.140nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007521(5-Bromo-N-[1-(4-fluoro-benzyl)-pyrrolidin-2-ylmeth...)
Affinity DataKi:  0.147nMAssay Description:Inhibition constant against dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.149nMAssay Description:Inhibitory constant against binding of [125I]- IBZM to rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228435(5-bromo-2-(2-((dimethylamino)methyl)-4-(3-fluoropr...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100135((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...)
Affinity DataKi:  0.170nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100135((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...)
Affinity DataKi:  0.170nMAssay Description:Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101413(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.190nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50035508(4-Iodo-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228438(3-(4-(2-amino-4-bromophenylthio)-3-((dimethylamino...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012965(5-Iodo-2,3-dihydro-benzofuran-7-carboxylic acid (1...)
Affinity DataKi:  0.230nMAssay Description:In vitro inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50228437(2-(2-((dimethylamino)methyl)-4-(2-fluoroethoxy)phe...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125I]5-iodo-2-[[2,2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol from SERT expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012961((-)-(S)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydro...)
Affinity DataKi:  0.261nMAssay Description:In vitro inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101412(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.270nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50041469((R,S) 7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetr...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [125I]trans-8-OH-PIPAT in membrane homogenates of hippocampal tissue ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50062273(3-Hydroxy-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Affinity DataKi:  0.340nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]-DTBZ from VMAT2 in rat striatal membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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