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TargetD(1A) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50016792(SK-83566 | 8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetra...)
Affinity DataKd:  2.30nMAssay Description:In vitro binding affinity to the rat striatal homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50016795(CHEMBL287504 | 3-Methyl-5-phenyl-2,3,4,5-tetrahydr...)
Affinity DataKd:  197nMAssay Description:In vitro binding affinity to the rat striatal homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50016794(CHEMBL34170 | 8-Chloro-5-(4-iodo-phenyl)-3-methyl-...)
Affinity DataKd:  1.40nMAssay Description:In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50038276(7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro...)
Affinity DataKd:  0.480nMAssay Description:Binding affinity was tested against dopamine receptor D3 in rat striatal membrane homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50020222(CHEMBL285755 | 7-Dipropylamino-5,6,7,8-tetrahydro-...)
Affinity DataKd:  0.670nMAssay Description:Tested for binding affinity against dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50043603(7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro...)
Affinity DataKd:  0.0500nMAssay Description:Binding affinity was tested against dopamine receptor D3 in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50038276(7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro...)
Affinity DataKd:  0.130nMAssay Description:Binding affinity was tested against dopamine receptor D3 in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM86708(CHEMBL31354 | CHEMBL514874 | NSC_104911 | CAS_1467...)
Affinity DataKd:  0.100nMAssay Description:In vitro binding affinity for 5-hydroxytryptamine 1A receptor was determined by measuring specific inhibition of [125I]-binding to rat hippocampal me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50005118(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  1.10nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50005118(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  7.10nMAssay Description:Affinity constant of compound was evaluated in human brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM11638(N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sul...)
Affinity DataKd:  1.5nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50020704(CHEMBL8475 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  0.430nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataKd:  0.0970nMAssay Description:Affinity constant of compound was evaluated in human brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKd:  0.170nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012964(CHEMBL8945 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  31nMAssay Description:Affinity constant of compound was evaluated in rat striatum tissue preparation.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataKd:  0.0970nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50040082(N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulf...)
Affinity DataKd:  1.5nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012964(CHEMBL8945 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  31nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKd:  0.170nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012961(N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-3-iodo...)
Affinity DataKd:  0.430nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012966(CHEMBL49405 | 8-[4-(4-Fluoro-2-iodo-phenyl)-4-oxo-...)
Affinity DataKd:  0.25nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012967(N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy...)
Affinity DataKd:  3nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50012968(CHEMBL50154 | 4-Azido-N-(1-benzyl-piperidin-4-yl)-...)
Affinity DataKd:  14nMAssay Description:Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50007170(CHEMBL26533 | Adamantane-1-carboxylic acid {4-[4-(...)
Affinity DataKd:  0.400nMAssay Description:Inhibition of binding of [125I]-8-OH-PIPAT ligand to 5-hydroxytryptamine 1A receptor of rat hippocampal homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50035508(CHEMBL29027 | p-MPPI | 4-Iodo-N-{2-[4-(2-methoxy-p...)
Affinity DataKd:  0.300nMAssay Description:The binding of [125I]MPPI ligand to 5-hydroxytryptamine 1A receptor of rat hippocampal homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107856(2-(1-Methyl-pyrrolidin-2-yl)-chroman-7-ol | (+-)-2...)
Affinity DataEC50:  600nMAssay Description:Recovery following a 5 min wash after 10 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107858(2-(1-Methyl-piperidin-2-yl)-chroman-7-ol | (+-)-2-...)
Affinity DataEC50:  410nMAssay Description:Receptor activation after 100 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107856(2-(1-Methyl-pyrrolidin-2-yl)-chroman-7-ol | (+-)-2...)
Affinity DataEC50:  962nMAssay Description:Receptor activation after 100 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107856(2-(1-Methyl-pyrrolidin-2-yl)-chroman-7-ol | (+-)-2...)
Affinity DataEC50:  197nMAssay Description:Recovery following a 5 min wash after 100 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107858(2-(1-Methyl-piperidin-2-yl)-chroman-7-ol | (+-)-2-...)
Affinity DataEC50:  199nMAssay Description:Receptor activation after 10 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107858(2-(1-Methyl-piperidin-2-yl)-chroman-7-ol | (+-)-2-...)
Affinity DataEC50:  1.19E+3nMAssay Description:Recovery following a 5 min wash after 10 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50107858(2-(1-Methyl-piperidin-2-yl)-chroman-7-ol | (+-)-2-...)
Affinity DataEC50:  851nMAssay Description:Recovery following a 5 min wash after 100 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM86708(CHEMBL31354 | CHEMBL514874 | NSC_104911 | CAS_1467...)
Affinity DataIC50: 2.20nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM86708(CHEMBL31354 | CHEMBL514874 | NSC_104911 | CAS_1467...)
Affinity DataIC50: 2.20nMAssay Description:In vitro binding affinity to 5-hydroxytryptamine 1A receptor using [125I](R)-(+)-trans-8-OH-PIPAT as radioligand in rat hippocampal homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50047471(N-tert-Butyl-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Affinity DataIC50: 15nMAssay Description:In vitro binding affinity to 5-hydroxytryptamine 1A receptor using [125I](R)-(+)-trans-8-OH-PIPAT as radioligand in rat hippocampal homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293707((2S,3R,E)-2-Amino-13-(4-iodophenyl)tridec-4-ene-1,...)
Affinity DataIC50: 500nMAssay Description:Inhibition of SphK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50009730(2-Amino-octadec-4-ene-1,3-diol(Sphingosine) | CHEM...)
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of SphK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50240721((E)-(2S,3R)-2-Dimethylamino-octadec-4-ene-1,3-diol...)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of SphK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293709((2S,3R,E)-2-Amino-15-(4-iodophenyl)pentadec-4-ene-...)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of SphK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293710((2S,3R,E)-2-Amino-16-(4-iodophenyl)hexadec-4-ene-1...)
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of SphK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293708((2S,3R,E)-2-Amino-14-(4-iodophenyl)tetradec-4-ene-...)
Affinity DataIC50: 2.78E+3nMAssay Description:Inhibition of SphK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50009730(2-Amino-octadec-4-ene-1,3-diol(Sphingosine) | CHEM...)
Affinity DataIC50: 3.86E+3nMAssay Description:Inhibition of SphK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293706((2S,3R,E)-2-Amino-11-(4-iodophenyl)undec-4-ene-1,3...)
Affinity DataIC50: 3.96E+3nMAssay Description:Inhibition of SphK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 1(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293711((2S,3R,E)-2-Amino-18-(4-iodophenyl)octadec-4-ene-1...)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of SphK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293709((2S,3R,E)-2-Amino-15-(4-iodophenyl)pentadec-4-ene-...)
Affinity DataIC50: 4.38E+3nMAssay Description:Inhibition of SphK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293707((2S,3R,E)-2-Amino-13-(4-iodophenyl)tridec-4-ene-1,...)
Affinity DataIC50: 5.73E+3nMAssay Description:Inhibition of SphK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293706((2S,3R,E)-2-Amino-11-(4-iodophenyl)undec-4-ene-1,3...)
Affinity DataIC50: 7.23E+3nMAssay Description:Inhibition of SphK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293710((2S,3R,E)-2-Amino-16-(4-iodophenyl)hexadec-4-ene-1...)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of SphK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293708((2S,3R,E)-2-Amino-14-(4-iodophenyl)tetradec-4-ene-...)
Affinity DataIC50: 1.66E+4nMAssay Description:Inhibition of SphK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50293711((2S,3R,E)-2-Amino-18-(4-iodophenyl)octadec-4-ene-1...)
Affinity DataIC50: 2.92E+4nMAssay Description:Inhibition of SphK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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