Compile Data Set for Download or QSAR
Found 111 with Last Name = 'lafontaine' and Initial = 'ja'
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277947(CHEMBL482559 | N-(4-(4-(2-(cyclopentylamino)pyrimi...)
Affinity DataKi:  9nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218166((R)-2-(2-(4-(oxazol-4-yl)phenoxy)ethylamino)-1-(py...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218165((R)-1-(pyridin-3-yl)-2-(2-(4-(thiazol-4-yl)phenoxy...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataKi:  12nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277909(CHEMBL483741 | N-cyclopentyl-4-(3-(tetrahydro-2H-p...)
Affinity DataKi:  12nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218173((R)-2-(2-(4-(2-methyloxazol-4-yl)phenoxy)ethylamin...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277869(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cyclopent...)
Affinity DataKi:  26nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277838(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cyclohexy...)
Affinity DataKi:  27nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277948(CHEMBL482753 | N-(4-(4-(2-(cyclopentylamino)pyrimi...)
Affinity DataKi:  28nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218170((R)-2-(2-(4-(2-(hydroxymethyl)oxazol-4-yl)phenoxy)...)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277946(3-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataKi:  36nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218168((R)-2-(2-(4-(2-ethyloxazol-4-yl)phenoxy)ethylamino...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218180((R)-2-(2-(4-(2-ethylthiazol-4-yl)phenoxy)ethylamin...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277873(CHEMBL485365 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...)
Affinity DataKi:  43nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277836(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-isopropyl...)
Affinity DataKi:  48nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218167((R)-2-(2-(4-(2-isopropyloxazol-4-yl)phenoxy)ethyla...)
Affinity DataKi:  49nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218177((R)-2-(2-(4-(2-(benzyloxymethyl)oxazol-4-yl)phenox...)
Affinity DataKi:  50nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218176((R)-1-(pyridin-3-yl)-2-(2-(4-(2-(pyridin-4-yl)thia...)
Affinity DataKi:  97nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218164((R)-2-(2-(4-(2-methylthiazol-4-yl)phenoxy)ethylami...)
Affinity DataKi:  100nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218182((R)-1-(pyridin-3-yl)-2-(2-(4-(2-(trifluoromethyl)t...)
Affinity DataKi:  100nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277907(CHEMBL520488 | N-isopropyl-4-(3-(1-(methylsulfonyl...)
Affinity DataKi:  101nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218185((1R)-1-(pyridin-3-yl)-2-(2-(4-(2-(pyridin-3-yl)thi...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218164((R)-2-(2-(4-(2-methylthiazol-4-yl)phenoxy)ethylami...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218172((R)-2-(2-(4-(2-cyclopentylthiazol-4-yl)phenoxy)eth...)
Affinity DataKi:  130nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218165((R)-1-(pyridin-3-yl)-2-(2-(4-(thiazol-4-yl)phenoxy...)
Affinity DataKi:  140nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218174((R)-2-(2-(4-(2-phenylthiazol-4-yl)phenoxy)ethylami...)
Affinity DataKi:  150nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277837(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cycloprop...)
Affinity DataKi:  151nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277908(CHEMBL518996 | N-(1-methylpiperidin-4-yl)-4-(3-(6-...)
Affinity DataKi:  162nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277905(CHEMBL520332 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...)
Affinity DataKi:  169nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218181((R)-2-(2-(4-(5-methyloxazol-4-yl)phenoxy)ethylamin...)
Affinity DataKi:  170nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218166((R)-2-(2-(4-(oxazol-4-yl)phenoxy)ethylamino)-1-(py...)
Affinity DataKi:  200nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218171((R)-2-(2-(4-(2-(methoxymethyl)oxazol-4-yl)phenoxy)...)
Affinity DataKi:  210nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218170((R)-2-(2-(4-(2-(hydroxymethyl)oxazol-4-yl)phenoxy)...)
Affinity DataKi:  270nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277868((R)-3-(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)pyrim...)
Affinity DataKi:  315nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218167((R)-2-(2-(4-(2-isopropyloxazol-4-yl)phenoxy)ethyla...)
Affinity DataKi:  360nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277872(CHEMBL485364 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...)
Affinity DataKi:  381nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218168((R)-2-(2-(4-(2-ethyloxazol-4-yl)phenoxy)ethylamino...)
Affinity DataKi:  400nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218173((R)-2-(2-(4-(2-methyloxazol-4-yl)phenoxy)ethylamin...)
Affinity DataKi:  400nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218174((R)-2-(2-(4-(2-phenylthiazol-4-yl)phenoxy)ethylami...)
Affinity DataKi:  500nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277906(CHEMBL484326 | N-isopropyl-4-(3-(piperidin-3-yl)-1...)
Affinity DataKi:  530nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277870(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-(1-methyl...)
Affinity DataKi:  1.02E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218179((R)-2-(2-(4-(2,5-dimethyloxazol-4-yl)phenoxy)ethyl...)
Affinity DataKi:  1.55E+3nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277870(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-(1-methyl...)
Affinity DataKi:  1.57E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277835(4-methylpyrimidine-2-thiol | CHEMBL455772)
Affinity DataKi:  2.06E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277871(CHEMBL485193 | N-isopropyl-4-(1H-pyrazol-4-yl)pyri...)
Affinity DataKi:  2.73E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50:  16nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50:  17nMAssay Description:Inhibition of to JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50078672(CHEMBL3415379)
Affinity DataIC50:  31nMAssay Description:Inhibition of human carbonic anhydrase 2 assessed as reduction in enzyme activity incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50078643(CHEMBL3415383)
Affinity DataIC50:  31nMAssay Description:Inhibition of human carbonic anhydrase 2 assessed as reduction in enzyme activity incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human carbonic anhydrase 2 assessed as reduction in enzyme activity incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
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