Found 89 with Last Name = 'lafuente-monasterio' and Initial = 'mj' TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of C-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Harvard School of Public Health
Harvard School of Public Health
Affinity DataIC50: 80nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of C-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Harvard School of Public Health
Harvard School of Public Health
Affinity DataIC50: 380nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town
Curated by ChEMBL
University of Cape Town
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Harvard School of Public Health
Harvard School of Public Health
Affinity DataIC50: 1.70E+3nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of C-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town
Curated by ChEMBL
University of Cape Town
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Harvard School of Public Health
Harvard School of Public Health
Affinity DataIC50: 3.50E+3nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town
Curated by ChEMBL
University of Cape Town
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town
Curated by ChEMBL
University of Cape Town
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of C-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town
Curated by ChEMBL
University of Cape Town
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Harvard School of Public Health
Harvard School of Public Health
Affinity DataIC50: 1.35E+4nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town
Curated by ChEMBL
University of Cape Town
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate measured for 10 to 30 mins in presence of NADPH regenerating system by ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate measured for 10 to 30 mins in presence of NADPH regenerating system ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured for 10 to 30 mins in presence of NADPH regenerating syste...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured for 10 to 30 mins in presence of NADPH regenerating system by ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured for 10 to 30 mins in presence of NADPH regenerating system by U...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate measured for 10 to 30 mins in presence of NADPH regenerating syste...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (30 to 396 residues) expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate after 20...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
