Compile Data Set for Download or QSAR
Found 1850 with Last Name = 'lai' and Initial = 'y'
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230846(CHEMBL2114071)
Affinity DataKi:  0.0680nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230859(CHEMBL309150)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human JAK2 (828-1132) expressed in baculovirus-infected Sf9 cells using EQEDEPEGDYFEWLE as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230848(CHEMBL70872)
Affinity DataKi:  0.110nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.190nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human JAK1 (837-1142) expressed in baculovirus-infected Sf9 cells using EQEDEPEGDYFEWLE as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50066109(3-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-2,6-...)
Affinity DataKi:  0.210nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50040253(3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120141(US8697708, 224)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261255(CHEMBL4084436)
Affinity DataKi:  0.300nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120132(US8697708, 18)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230844(CHEMBL71470)
Affinity DataKi:  0.340nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230870(CHEMBL70498)
Affinity DataKi:  0.340nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230861(CHEMBL2114072)
Affinity DataKi:  0.360nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230853(CHEMBL304165)
Affinity DataKi:  0.370nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261268(CHEMBL4062758)
Affinity DataKi:  0.400nMAssay Description:Inhibition of JAK2 (unknown origin) assessed as reduction in EPO-mediated STAT5 phosphorylation by cell based readout assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human GST-fused JAK3 catalytic domain expressed in baculovirus-infected Sf9 cells using polyglutamic acid-tyrosine as substrate after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120140(US8697708, 223)
Affinity DataKi:  0.400nM ΔG°:  -53.1kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120128(US8697708, 2)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261261(CHEMBL4075453)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120143(US8697708, 236)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261256(CHEMBL4071399)
Affinity DataKi:  0.5nMAssay Description:Inhibition of CDK5/p35 (unknown origin) using ULingt-4E-BP as substrate after 1 hr in presence of ATP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120128(US8697708, 2)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230847(CHEMBL2114069)
Affinity DataKi:  0.580nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261254(CHEMBL4074130)
Affinity DataKi:  0.600nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261274(CHEMBL4062680)
Affinity DataKi:  0.600nMAssay Description:Inhibition of JAK2 (unknown origin) assessed as reduction in EPO-mediated STAT5 phosphorylation by cell based readout assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261260(CHEMBL4069942)
Affinity DataKi:  0.600nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261276(CHEMBL4092116)
Affinity DataKi:  0.600nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261270(CHEMBL4093872)
Affinity DataKi:  0.600nMAssay Description:Inhibition of JAK2 (unknown origin) assessed as reduction in EPO-mediated STAT5 phosphorylation by cell based readout assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230851(CHEMBL70347)
Affinity DataKi:  0.680nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261273(CHEMBL4076947)
Affinity DataKi:  0.700nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261269(CHEMBL4092191)
Affinity DataKi:  0.700nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261257(CHEMBL4099854)
Affinity DataKi:  0.700nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human GST-fused JAK1 catalytic domain expressed in baculovirus-infected Sf9 cells using polyglutamic acid-tyrosine as substrate after 3...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human GST-fused JAK2 catalytic domain expressed in baculovirus-infected Sf9 cells using polyglutamic acid-tyrosine as substrate after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120142(US8697708, 227)
Affinity DataKi:  0.800nM ΔG°:  -51.4kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261283(CHEMBL4093172)
Affinity DataKi:  0.800nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261262(CHEMBL4070262)
Affinity DataKi:  1nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120133(US8697708, 22)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230850(CHEMBL309149)
Affinity DataKi:  1.10nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261271(CHEMBL4080904)
Affinity DataKi:  1.20nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261267(CHEMBL4097446)
Affinity DataKi:  1.20nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50040260(2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-2,6-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261253(CHEMBL4100889)
Affinity DataKi:  1.30nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120131(US8697708, 16)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Defense Medical Center

Curated by ChEMBL
LigandPNGBDBM50230871(CHEMBL307961)
Affinity DataKi:  1.40nMAssay Description:Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120129(US8697708, 9)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120139(US8697708, 213)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM120137(US8697708, 129)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

US Patent
LigandPNGBDBM50261215(CHEMBL2387223)
Affinity DataKi:  1.60nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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