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TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176494((3S)-3-(6-(3-methyl-4-(quinoxalin-2-ylamino)benzam...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176493((S)-3-((S)-2-((S)-3-methyl-2-(4-(quinoxalin-2-ylam...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176496((3S)-3-(6-(4-(6-methylquinoxalin-2-ylamino)benzami...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176495((3S)-4-oxo-3-(2-phenyl-6-(4-(quinoxalin-2-ylamino)...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176510((S)-4-oxo-3-(2-((4-(quinoxalin-2-ylamino)benzamido...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176500((3S)-4-oxo-3-(6-(4-(quinoxalin-2-ylamino)benzamido...)
Affinity DataKi:  7nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176519((S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176509((3S)-3-(2-(2-fluorophenyl)-6-(4-(quinoxalin-2-ylam...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2 [11-552](Human)
Inspire

US Patent
LigandPNGBDBM97666(US8476295, 1.1.04)
Affinity DataKi:  10nMpH: 7.2Assay Description:Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176505((3S)-3-(2-ethyl-6-(4-(quinoxalin-2-ylamino)benzami...)
Affinity DataKi:  16nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM280((S)-5-{[5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-p...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2 [11-552](Human)
Inspire

US Patent
LigandPNGBDBM97664(US8476295, 1.1.02)
Affinity DataKi:  20nMpH: 7.2Assay Description:Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM223((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM226((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM263((S)-5-({5-[1-Carboxymethyl-2-oxo-3-(pyridin-3-ylme...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2 [11-552](Human)
Inspire

US Patent
LigandPNGBDBM97665(US8476295, 1.1.03)
Affinity DataKi:  21nMpH: 7.2Assay Description:Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetRho-associated protein kinase 2 [11-552](Human)
Inspire

US Patent
LigandPNGBDBM97663(US8476295, 1.1.01)
Affinity DataKi:  29nMpH: 7.2Assay Description:Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM264((S)-5-({5-[1-Carboxymethyl-2-oxo-3-(pyridin-4-ylme...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM224((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM222((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176508((S)-4-oxo-3-(2-((4-(quinoxalin-2-ylamino)benzamido...)
Affinity DataKi:  35nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1 [17-535](Human)
Inspire

US Patent
LigandPNGBDBM97666(US8476295, 1.1.04)
Affinity DataKi:  35nMpH: 7.2Assay Description:Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM227((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  40nM ΔG°:  -42.2kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176502((3S)-4-oxo-3-(6-(4-(quinoxalin-2-yloxy)benzamido)-...)
Affinity DataKi:  43nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM225((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)
Affinity DataKi:  50nM ΔG°:  -41.7kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM221(5-{[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  50nM ΔG°:  -41.7kJ/molepH: 7.4 T: 25°CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176504((3S)-3-(6-(4-(6-chloropyrazin-2-ylamino)benzamido)...)
Affinity DataKi:  54nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1 [17-535](Human)
Inspire

US Patent
LigandPNGBDBM97665(US8476295, 1.1.03)
Affinity DataKi:  59nMpH: 7.2Assay Description:Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM232((S)-5-({3-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  60nM ΔG°:  -41.2kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM10198(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  70nM ΔG°:  -40.8kJ/moleT: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM230((S)-5-{[5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-t...)
Affinity DataKi:  70nM ΔG°:  -40.8kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM10193(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/molepH: 7.4 T: 22°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1 [17-535](Human)
Inspire

US Patent
LigandPNGBDBM97663(US8476295, 1.1.01)
Affinity DataKi:  72nMpH: 7.2Assay Description:Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM229((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  90nM ΔG°:  -40.2kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM219(5-({[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methy...)
Affinity DataKi:  90nM ΔG°:  -40.2kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM222((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  90nM ΔG°:  -40.2kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM224((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  90nM ΔG°:  -40.2kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM223((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  90nM ΔG°:  -40.2kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1 [17-535](Human)
Inspire

US Patent
LigandPNGBDBM97664(US8476295, 1.1.02)
Affinity DataKi:  91nMpH: 7.2Assay Description:Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM10196(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/molepH: 7.4 T: 22°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM10199(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  100nM ΔG°:  -40.0kJ/moleT: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM10205((3S)-4-oxo-3-(6-{[3-(5-oxo-4,5-dihydro-1,2,4-oxadi...)
Affinity DataKi:  100nM ΔG°:  -40.0kJ/moleT: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176497((S)-4-oxo-3-(4-((4-(quinoxalin-2-ylamino)benzamido...)
Affinity DataKi:  100nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176513((3S)-4-oxo-3-(6-(4-(pyrazin-2-ylamino)benzamido)-2...)
Affinity DataKi:  100nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM10188(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/molepH: 7.4 T: 22°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM10189(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/molepH: 7.4 T: 22°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176512((S)-4-oxo-3-(2-((4-(quinoxalin-2-ylamino)benzamido...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM225((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)
Affinity DataKi:  120nM ΔG°:  -39.5kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM225((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)
Affinity DataKi:  120nM ΔG°:  -39.5kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM222((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  120nM ΔG°:  -39.5kJ/molepH: 7.4 T: 25°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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