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TargetCTP synthase 2(Rattus norvegicus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMyeloperoxidase(Homo sapiens (Human))
University of Otago Christchurch

LigandPNGBDBM217354(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)
Affinity DataIC50:  5.01nMpH: 6.5Assay Description:Assays were performed at 22 C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50:  13nMAssay Description:Inhibition of human CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 2(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50:  18nMAssay Description:Inhibition of human CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetCTP synthase 1(Mus musculus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50:  18nMAssay Description:Inhibition of mouse CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 2(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50:  19nMAssay Description:Inhibition of human CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413241(CHEMBL513412)
Affinity DataIC50:  19.9nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCTP synthase 2(Rattus norvegicus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50:  23nMAssay Description:Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetMyeloperoxidase(Homo sapiens (Human))
University of Otago Christchurch

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataIC50:  25.1nMpH: 6.5Assay Description:Assays were performed at 22 C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413240(CHEMBL471412)
Affinity DataIC50:  25.1nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCTP synthase 1(Mus musculus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50:  26nMAssay Description:Inhibition of mouse CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetCTP synthase 2(Mus musculus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50:  27nMAssay Description:Inhibition of mouse CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413240(CHEMBL471412)
Affinity DataIC50:  31.6nMAssay Description:Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by membrane binding assay in presence of [35S]GTPgammaSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50:  32nMAssay Description:Inhibition of human CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetCTP synthase 2(Mus musculus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609674(CHEMBL5283284)
Affinity DataIC50:  33nMAssay Description:Inhibition of mouse CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetCTP synthase 2(Rattus norvegicus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50:  35nMAssay Description:Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413239(CHEMBL472268)
Affinity DataIC50:  39.8nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413240(CHEMBL471412)
Affinity DataIC50:  39.8nMAssay Description:Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoperoxidase(Bos taurus (Bovine))
University of Otago Christchurch

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataIC50:  40nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50:  42nMAssay Description:Inhibition of human CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 1(Mus musculus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50:  53nMAssay Description:Inhibition of mouse CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University of Otago Christchurch

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataIC50:  63nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413238(CHEMBL511782)
Affinity DataIC50:  63.1nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413247(CHEMBL472455)
Affinity DataIC50:  79.4nMAssay Description:Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413252(CHEMBL469727)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413245(CHEMBL469535)
Affinity DataIC50: >100nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCTP synthase 2(Mus musculus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50:  113nMAssay Description:Inhibition of mouse CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413247(CHEMBL472455)
Affinity DataIC50:  126nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609644(CHEMBL5288271)
Affinity DataIC50:  180nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413251(CHEMBL469728)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609662(CHEMBL5275093)
Affinity DataIC50:  210nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 2(Rattus norvegicus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609669(CHEMBL5288393)
Affinity DataIC50:  235nMAssay Description:Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 2(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609670(CHEMBL5277468)
Affinity DataIC50:  242nMAssay Description:Inhibition of human CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609647(CHEMBL5291055)
Affinity DataIC50:  250nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413247(CHEMBL472455)
Affinity DataIC50:  251nMAssay Description:Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by membrane binding assay in presence of [35S]GTPgammaSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413250(CHEMBL513370)
Affinity DataIC50:  316nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoperoxidase(Bos taurus (Bovine))
University of Otago Christchurch

LigandPNGBDBM50015089(2,N-Dihydroxy-benzamide | CHEMBL309339 | N,2-dihyd...)
Affinity DataIC50:  400nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609664(CHEMBL5270156)
Affinity DataIC50:  420nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609665(CHEMBL5288933)
Affinity DataIC50:  430nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609663(CHEMBL5288354)
Affinity DataIC50:  440nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 1(Mus musculus)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609669(CHEMBL5288393)
Affinity DataIC50:  440nMAssay Description:Inhibition of mouse CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609668(CHEMBL5287919)
Affinity DataIC50:  440nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609652(CHEMBL5284514)
Affinity DataIC50:  570nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609669(CHEMBL5288393)
Affinity DataIC50:  580nMAssay Description:Inhibition of human CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCTP synthase 2(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609669(CHEMBL5288393)
Affinity DataIC50:  710nMAssay Description:Inhibition of human CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMyeloperoxidase(Homo sapiens (Human))
University of Otago Christchurch

LigandPNGBDBM217356(2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...)
Affinity DataIC50:  790nMpH: 6.5Assay Description:Assays were performed at 22 C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413240(CHEMBL471412)
Affinity DataIC50:  794nMAssay Description:Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413249(CHEMBL450470)
Affinity DataIC50:  794nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCTP synthase 1(Homo sapiens)
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50609661(CHEMBL5278356)
Affinity DataIC50:  950nMAssay Description:Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50413248(CHEMBL513757)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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