Compile Data Set for Download or QSAR
Found 1385 with Last Name = 'lazarus' and Initial = 'lh'
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50375695(CHEMBL270984)
Show SMILES Cc1cc(O)cc(O)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C43H49N5O9/c1-27-20-32(49)23-38(50)33(27)24-34(44)41(53)48-25-31-17-9-8-16-30(31)22-37(48)40(52)47-36(21-28-12-4-2-5-13-28)39(51)46-35(42(54)55)18-10-11-19-45-43(56)57-26-29-14-6-3-7-15-29/h2-9,12-17,20,23,34-37,49-50H,10-11,18-19,21-22,24-26,44H2,1H3,(H,45,56)(H,46,51)(H,47,52)(H,54,55)/t34-,35-,36-,37+/m0/s1
Affinity DataKi:  0.0190nMAssay Description:Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50121649(2-[({2-[2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2CC1C(=O)NCc1nc2ccccc2n1C(O)=O
Show InChI InChI=1S/C30H31N5O5/c1-17-11-21(36)12-18(2)22(17)14-23(31)29(38)34-16-20-8-4-3-7-19(20)13-26(34)28(37)32-15-27-33-24-9-5-6-10-25(24)35(27)30(39)40/h3-12,23,26,36H,13-16,31H2,1-2H3,(H,32,37)(H,39,40)/t23-,26?/m0/s1
Affinity DataKi:  0.0210nMAssay Description:Inhibition of [3H]DPDPE binding to Opioid receptor delta 1 of rat brain P2 synaptosomesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50179190(2-(2-(((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethy...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2n1CC(O)=O
Show InChI InChI=1S/C31H33N5O5/c1-18-11-22(37)12-19(2)23(18)14-24(32)31(41)36-16-21-8-4-3-7-20(21)13-27(36)30(40)33-15-28-34-25-9-5-6-10-26(25)35(28)17-29(38)39/h3-12,24,27,37H,13-17,32H2,1-2H3,(H,33,40)(H,38,39)/t24-,27-/m0/s1
Affinity DataKi:  0.0210nMAssay Description:Displacement of [3H]deltorphin II from rat delta opioid receptor in brain P2 synaptosomesMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50194487(3-[4'-(H-Dmt)-aminobutyl]-6-[3'-(H-Dmt)-aminopropy...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCc1nc(C)c(CCCNC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)[nH]c1=O
Show InChI InChI=1S/C34H48N6O5/c1-19-13-24(41)14-20(2)26(19)17-28(35)32(43)37-11-7-6-9-31-34(45)40-30(23(5)39-31)10-8-12-38-33(44)29(36)18-27-21(3)15-25(42)16-22(27)4/h13-16,28-29,41-42H,6-12,17-18,35-36H2,1-5H3,(H,37,43)(H,38,44)(H,40,45)/t28-,29-/m0/s1
Affinity DataKi:  0.0210nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat synaptosomes P2 fractionMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50266025((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)NCc1ccccc1
Show InChI InChI=1S/C30H34N4O4/c1-19-12-24(35)13-20(2)25(19)15-26(31)30(38)34-18-23-11-7-6-10-22(23)14-27(34)29(37)33-17-28(36)32-16-21-8-4-3-5-9-21/h3-13,26-27,35H,14-18,31H2,1-2H3,(H,32,36)(H,33,37)/t26-,27-/m0/s1
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in Sprague-Dawley rat brain synaptosomal membranesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Vrije Universiteit Brussels

Curated by ChEMBL
LigandPNGBDBM50266025((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)NCc1ccccc1
Show InChI InChI=1S/C30H34N4O4/c1-19-12-24(35)13-20(2)25(19)15-26(31)30(38)34-18-23-11-7-6-10-22(23)14-27(34)29(37)33-17-28(36)32-16-21-8-4-3-5-9-21/h3-13,26-27,35H,14-18,31H2,1-2H3,(H,32,36)(H,33,37)/t26-,27-/m0/s1
Affinity DataKi:  0.0310nMAssay Description:Binding affinity to delta opioid receptorMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50266025((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)NCc1ccccc1
Show InChI InChI=1S/C30H34N4O4/c1-19-12-24(35)13-20(2)25(19)15-26(31)30(38)34-18-23-11-7-6-10-22(23)14-27(34)29(37)33-17-28(36)32-16-21-8-4-3-5-9-21/h3-13,26-27,35H,14-18,31H2,1-2H3,(H,32,36)(H,33,37)/t26-,27-/m0/s1
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50266025((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)NCc1ccccc1
Show InChI InChI=1S/C30H34N4O4/c1-19-12-24(35)13-20(2)25(19)15-26(31)30(38)34-18-23-11-7-6-10-22(23)14-27(34)29(37)33-17-28(36)32-16-21-8-4-3-5-9-21/h3-13,26-27,35H,14-18,31H2,1-2H3,(H,32,36)(H,33,37)/t26-,27-/m0/s1
Affinity DataKi:  0.0310nMAssay Description:Binding affinity at Opioid receptor delta 1 using rat brain receptor (P2 synaptosome) assayMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50179191((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-2-((S)-2-...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2[nH]1
Show InChI InChI=1S/C29H31N5O3/c1-17-11-21(35)12-18(2)22(17)14-23(30)29(37)34-16-20-8-4-3-7-19(20)13-26(34)28(36)31-15-27-32-24-9-5-6-10-25(24)33-27/h3-12,23,26,35H,13-16,30H2,1-2H3,(H,31,36)(H,32,33)/t23-,26-/m0/s1
Affinity DataKi:  0.0350nMAssay Description:Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Vrije Universiteit Brussels

Curated by ChEMBL
LigandPNGBDBM50027229(CHEMBL2375157)
Show SMILES C[C@@H](CN1Cc2ccccc2C[C@H]1C(=O)NCC(=O)NCc1nc2ccccc2[nH]1)Cc1c(C)cc(O)cc1C
Show InChI InChI=1S/C32H37N5O3/c1-20(12-26-21(2)13-25(38)14-22(26)3)18-37-19-24-9-5-4-8-23(24)15-29(37)32(40)34-17-31(39)33-16-30-35-27-10-6-7-11-28(27)36-30/h4-11,13-14,20,29,38H,12,15-19H2,1-3H3,(H,33,39)(H,34,40)(H,35,36)/t20-,29+/m1/s1
Affinity DataKi:  0.0350nMAssay Description:Binding affinity to delta opioid receptorMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50179191((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-2-((S)-2-...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2[nH]1
Show InChI InChI=1S/C29H31N5O3/c1-17-11-21(35)12-18(2)22(17)14-23(30)29(37)34-16-20-8-4-3-7-19(20)13-26(34)28(36)31-15-27-32-24-9-5-6-10-25(24)33-27/h3-12,23,26,35H,13-16,30H2,1-2H3,(H,31,36)(H,32,33)/t23-,26-/m0/s1
Affinity DataKi:  0.0350nMAssay Description:Displacement of [3H]deltorphin II from rat delta opioid receptor in brain P2 synaptosomesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50297286(1H-benzo[d]imidazol-2-yl 2-((S)-2-((S)-2-amino-3-(...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C30H31N5O4/c1-17-11-21(36)12-18(2)22(17)14-23(31)30(39)35-16-20-8-4-3-7-19(20)13-26(35)29(38)32-15-27(37)28-33-24-9-5-6-10-25(24)34-28/h3-12,23,26,36H,13-16,31H2,1-2H3,(H,32,38)(H,33,34)/t23-,26-/m0/s1
Affinity DataKi:  0.0350nMAssay Description:Displacement of [3H]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50179191((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-2-((S)-2-...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2[nH]1
Show InChI InChI=1S/C29H31N5O3/c1-17-11-21(35)12-18(2)22(17)14-23(30)29(37)34-16-20-8-4-3-7-19(20)13-26(34)28(36)31-15-27-32-24-9-5-6-10-25(24)33-27/h3-12,23,26,35H,13-16,30H2,1-2H3,(H,31,36)(H,32,33)/t23-,26-/m0/s1
Affinity DataKi:  0.0350nMAssay Description:Inhibition of [3H]DPDPE binding to Opioid receptor delta 1 of rat brain P2 synaptosomesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50179191((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-2-((S)-2-...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2[nH]1
Show InChI InChI=1S/C29H31N5O3/c1-17-11-21(35)12-18(2)22(17)14-23(30)29(37)34-16-20-8-4-3-7-19(20)13-26(34)28(36)31-15-27-32-24-9-5-6-10-25(24)33-27/h3-12,23,26,35H,13-16,30H2,1-2H3,(H,31,36)(H,32,33)/t23-,26-/m0/s1
Affinity DataKi:  0.0350nMAssay Description:Displacement of [3H]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50179191((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-2-((S)-2-...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2[nH]1
Show InChI InChI=1S/C29H31N5O3/c1-17-11-21(35)12-18(2)22(17)14-23(30)29(37)34-16-20-8-4-3-7-19(20)13-26(34)28(36)31-15-27-32-24-9-5-6-10-25(24)33-27/h3-12,23,26,35H,13-16,30H2,1-2H3,(H,31,36)(H,32,33)/t23-,26-/m0/s1
Affinity DataKi:  0.0350nMAssay Description:Binding affinity to delta opioid receptor in Sprague-Dawley rat brain membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50297301((S)-1H-benzo[d]imidazol-2-yl 3-acetoxy-2-((S)-2-((...)
Show SMILES CC(=O)OC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C33H35N5O6/c1-18-12-23(40)13-19(2)24(18)15-25(34)33(43)38-16-22-9-5-4-8-21(22)14-29(38)32(42)37-28(17-44-20(3)39)30(41)31-35-26-10-6-7-11-27(26)36-31/h4-13,25,28-29,40H,14-17,34H2,1-3H3,(H,35,36)(H,37,42)/t25-,28-,29-/m0/s1
Affinity DataKi:  0.0350nMAssay Description:Displacement of [3H]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50179191((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-2-((S)-2-...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2[nH]1
Show InChI InChI=1S/C29H31N5O3/c1-17-11-21(35)12-18(2)22(17)14-23(30)29(37)34-16-20-8-4-3-7-19(20)13-26(34)28(36)31-15-27-32-24-9-5-6-10-25(24)33-27/h3-12,23,26,35H,13-16,30H2,1-2H3,(H,31,36)(H,32,33)/t23-,26-/m0/s1
Affinity DataKi:  0.0350nMAssay Description:Binding affinity at Opioid receptor delta 1 using rat brain receptor (P2 synaptosome) assayMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272171(CHEMBL501202 | H-Dmt-Tic-Asp-NH-Ph)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C31H34N4O6/c1-18-12-23(36)13-19(2)24(18)15-25(32)31(41)35-17-21-9-7-6-8-20(21)14-27(35)30(40)34-26(16-28(37)38)29(39)33-22-10-4-3-5-11-22/h3-13,25-27,36H,14-17,32H2,1-2H3,(H,33,39)(H,34,40)(H,37,38)/t25-,26-,27-/m0/s1
Affinity DataKi:  0.0360nMAssay Description:Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50157686(5-[({5-[(2S)-2-({2-[(2S)-2-amino-3-(4-hydroxy-2,6-...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](CCC(O)=O)C(=O)NCCCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12
Show InChI InChI=1S/C52H54N6O11S/c1-28-20-35(61)21-29(2)39(28)26-41(53)50(66)58-27-31-9-5-4-8-30(31)22-43(58)49(65)57-42(16-17-46(62)63)48(64)54-18-6-3-7-19-55-52(70)56-32-10-13-36(40(23-32)51(67)68)47-37-14-11-33(59)24-44(37)69-45-25-34(60)12-15-38(45)47/h4-5,8-15,20-21,23-25,41-43,59,61H,3,6-7,16-19,22,26-27,53H2,1-2H3,(H,54,64)(H,57,65)(H,62,63)(H,67,68)(H2,55,56,70)/t41-,42-,43?/m0/s1
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in rat brain synaptosomes P2 fractionMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50130611(2-Amino-N-{4-[2-amino-3-(4-hydroxy-2,6-dimethyl-ph...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCNC(=O)[C@H](N)Cc1c(C)cc(O)cc1C
Show InChI InChI=1S/C26H38N4O4/c1-15-9-19(31)10-16(2)21(15)13-23(27)25(33)29-7-5-6-8-30-26(34)24(28)14-22-17(3)11-20(32)12-18(22)4/h9-12,23-24,31-32H,5-8,13-14,27-28H2,1-4H3,(H,29,33)(H,30,34)/t23-,24+
Affinity DataKi:  0.0400nMAssay Description:Binding affinity for Opioid receptor mu 1 using [3H]-DAGO in rat brain P2 synaptosomal preparationMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50083160((S)-2-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Show SMILES C[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C34H44N4O4/c1-19-8-27(39)9-20(2)28(19)14-29(35)33(42)38-18-26-7-5-4-6-25(26)13-30(38)32(41)36-21(3)31(40)37-34-15-22-10-23(16-34)12-24(11-22)17-34/h4-9,21-24,29-30,39H,10-18,35H2,1-3H3,(H,36,41)(H,37,40)/t21-,22-,23+,24-,29-,30-,34?/m0/s1
Affinity DataKi:  0.0400nMAssay Description:Binding affinity at Opioid receptor delta 1 from rat brain synaptosomal preparations by H-Dmt-Tic-OH displacement.More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50297303((S)-5-(1H-benzo[d]imidazol-2-yloxy)-4-((S)-2-((S)-...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C33H35N5O6/c1-18-13-22(39)14-19(2)23(18)16-24(34)33(44)38-17-21-8-4-3-7-20(21)15-28(38)32(43)37-27(11-12-29(40)41)30(42)31-35-25-9-5-6-10-26(25)36-31/h3-10,13-14,24,27-28,39H,11-12,15-17,34H2,1-2H3,(H,35,36)(H,37,43)(H,40,41)/t24-,27-,28-/m0/s1
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Vrije Universiteit Brussels

Curated by ChEMBL
LigandPNGBDBM50272081(2-[2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propi...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)Nc1ccccc1
Show InChI InChI=1S/C29H32N4O4/c1-18-12-23(34)13-19(2)24(18)15-25(30)29(37)33-17-21-9-7-6-8-20(21)14-26(33)28(36)31-16-27(35)32-22-10-4-3-5-11-22/h3-13,25-26,34H,14-17,30H2,1-2H3,(H,31,36)(H,32,35)/t25-,26-/m0/s1
Affinity DataKi:  0.0420nMAssay Description:Binding affinity to delta opioid receptorMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272081(2-[2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propi...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)Nc1ccccc1
Show InChI InChI=1S/C29H32N4O4/c1-18-12-23(34)13-19(2)24(18)15-25(30)29(37)33-17-21-9-7-6-8-20(21)14-26(33)28(36)31-16-27(35)32-22-10-4-3-5-11-22/h3-13,25-26,34H,14-17,30H2,1-2H3,(H,31,36)(H,32,35)/t25-,26-/m0/s1
Affinity DataKi:  0.0420nMAssay Description:Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50221787(CHEMBL3216418)
Show SMILES Cl.Cl.Cc1cc(O)cc(C)c1CC(N)C(=O)NCCCc1nc(O)c(CCCNC(=O)C(N)Cc2c(C)cc(O)cc2C)nc1C
Show InChI InChI=1S/C33H46N6O5.2ClH/c1-18-12-23(40)13-19(2)25(18)16-27(34)31(42)36-10-6-8-29-22(5)38-30(33(44)39-29)9-7-11-37-32(43)28(35)17-26-20(3)14-24(41)15-21(26)4;;/h12-15,27-28,40-41H,6-11,16-17,34-35H2,1-5H3,(H,36,42)(H,37,43)(H,39,44);2*1H
Affinity DataKi:  0.0420nMAssay Description:Compound was tested for Opioid receptor mu 1 agonism in isolated tissues from guinea pig ileumMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272081(2-[2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propi...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)Nc1ccccc1
Show InChI InChI=1S/C29H32N4O4/c1-18-12-23(34)13-19(2)24(18)15-25(30)29(37)33-17-21-9-7-6-8-20(21)14-26(33)28(36)31-16-27(35)32-22-10-4-3-5-11-22/h3-13,25-26,34H,14-17,30H2,1-2H3,(H,31,36)(H,32,35)/t25-,26-/m0/s1
Affinity DataKi:  0.0420nMAssay Description:Binding affinity at Opioid receptor delta 1 using rat brain receptor (P2 synaptosome) assayMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50121648(2-({2-[2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-p...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](Cc1nc2ccccc2[nH]1)C(O)=O
Show InChI InChI=1S/C31H33N5O5/c1-17-11-21(37)12-18(2)22(17)14-23(32)30(39)36-16-20-8-4-3-7-19(20)13-27(36)29(38)35-26(31(40)41)15-28-33-24-9-5-6-10-25(24)34-28/h3-12,23,26-27,37H,13-16,32H2,1-2H3,(H,33,34)(H,35,38)(H,40,41)/t23-,26-,27?/m0/s1
Affinity DataKi:  0.0420nMAssay Description:Inhibition of [3H]DPDPE binding to Opioid receptor delta 1 of rat brain P2 synaptosomesMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50212613(CHEMBL266122 | Tyr-Pro-Dmp-Phe-NH2)
Show SMILES Cc1cccc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H41N5O5/c1-21-8-6-9-22(2)26(21)20-29(32(42)37-28(31(36)41)19-23-10-4-3-5-11-23)38-33(43)30-12-7-17-39(30)34(44)27(35)18-24-13-15-25(40)16-14-24/h3-6,8-11,13-16,27-30,40H,7,12,17-20,35H2,1-2H3,(H2,36,41)(H,37,42)(H,38,43)/t27-,28-,29-,30-/m0/s1
Affinity DataKi:  0.0440nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Sprague-Dawley rat brain P2 synaptosome membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50049378(1-((S)-2-{(S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C1(CCCCC1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(N)=O
Show InChI InChI=1S/C40H58N8O8/c1-23(2)32(37(54)43-22-31(42)50)46-38(55)33(24(3)4)47-39(56)40(18-10-7-11-19-40)48-36(53)30(21-26-12-8-6-9-13-26)45-34(51)25(5)44-35(52)29(41)20-27-14-16-28(49)17-15-27/h6,8-9,12-17,23-25,29-30,32-33,49H,7,10-11,18-22,41H2,1-5H3,(H2,42,50)(H,43,54)(H,44,52)(H,45,51)(H,46,55)(H,47,56)(H,48,53)/t25-,29-,30-,32-,33-/m0/s1
Affinity DataKi:  0.0450nMAssay Description:Displacement of [3H]-DPDPE (0.63 nM) from Opioid receptor delta 1More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50121645(2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)pr...)
Show SMILES C[C@H](NC(=O)C1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C30H33N5O3/c1-17-12-22(36)13-18(2)23(17)15-24(31)30(38)35-16-21-9-5-4-8-20(21)14-27(35)29(37)32-19(3)28-33-25-10-6-7-11-26(25)34-28/h4-13,19,24,27,36H,14-16,31H2,1-3H3,(H,32,37)(H,33,34)/t19-,24-,27?/m0/s1
Affinity DataKi:  0.0470nMAssay Description:Inhibition of [3H]DPDPE binding to Opioid receptor delta 1 of rat brain P2 synaptosomesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50297294((S)-1H-benzo[d]imidazol-2-yl 2-((S)-2-((S)-2-amino...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C37H37N5O4/c1-22-16-27(43)17-23(2)28(22)20-29(38)37(46)42-21-26-13-7-6-12-25(26)19-33(42)36(45)41-32(18-24-10-4-3-5-11-24)34(44)35-39-30-14-8-9-15-31(30)40-35/h3-17,29,32-33,43H,18-21,38H2,1-2H3,(H,39,40)(H,41,45)/t29-,32-,33-/m0/s1
Affinity DataKi:  0.0490nMAssay Description:Displacement of [3H]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50130617(2-Amino-N-{6-[2-amino-3-(4-hydroxy-2,6-dimethyl-ph...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCCCNC(=O)[C@H](N)Cc1c(C)cc(O)cc1C
Show InChI InChI=1S/C28H42N4O4/c1-17-11-21(33)12-18(2)23(17)15-25(29)27(35)31-9-7-5-6-8-10-32-28(36)26(30)16-24-19(3)13-22(34)14-20(24)4/h11-14,25-26,33-34H,5-10,15-16,29-30H2,1-4H3,(H,31,35)(H,32,36)/t25-,26+
Affinity DataKi:  0.0500nMAssay Description:Binding affinity for Opioid receptor mu 1 using [3H]-DAGO in rat brain P2 synaptosomal preparationMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50194488(6-[4'-(H-Dmt)-aminobutyl]-3-[3'-(H-Dmt)-aminopropy...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCc1[nH]c(=O)c(CCCNC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)nc1C
Show InChI InChI=1S/C34H48N6O5/c1-19-13-24(41)14-20(2)26(19)17-28(35)32(43)37-11-7-6-9-30-23(5)39-31(34(45)40-30)10-8-12-38-33(44)29(36)18-27-21(3)15-25(42)16-22(27)4/h13-16,28-29,41-42H,6-12,17-18,35-36H2,1-5H3,(H,37,43)(H,38,44)(H,40,45)/t28-,29-/m0/s1
Affinity DataKi:  0.0510nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat synaptosomes P2 fractionMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50297299((S)-1H-benzo[d]imidazol-2-yl 4-amino-2-((S)-2-((S)...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C32H34N6O5/c1-17-11-21(39)12-18(2)22(17)14-23(33)32(43)38-16-20-8-4-3-7-19(20)13-27(38)31(42)37-26(15-28(34)40)29(41)30-35-24-9-5-6-10-25(24)36-30/h3-12,23,26-27,39H,13-16,33H2,1-2H3,(H2,34,40)(H,35,36)(H,37,42)/t23-,26-,27-/m0/s1
Affinity DataKi:  0.0510nMAssay Description:Displacement of [3H]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50049376(1-((S)-2-{(S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C1(CCCC1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(N)=O
Show InChI InChI=1S/C39H56N8O8/c1-22(2)31(36(53)42-21-30(41)49)45-37(54)32(23(3)4)46-38(55)39(17-9-10-18-39)47-35(52)29(20-25-11-7-6-8-12-25)44-33(50)24(5)43-34(51)28(40)19-26-13-15-27(48)16-14-26/h6-8,11-16,22-24,28-29,31-32,48H,9-10,17-21,40H2,1-5H3,(H2,41,49)(H,42,53)(H,43,51)(H,44,50)(H,45,54)(H,46,55)(H,47,52)/t24-,28-,29-,31-,32-/m0/s1
Affinity DataKi:  0.0540nMAssay Description:Displacement of [3H]-DPDPE (0.63 nM) from Opioid receptor delta 1More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50199865((S)-N-((S)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-y...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H42N6O5/c1-21-15-25(43)16-22(2)27(21)19-28(37)36(47)42-14-8-13-32(42)35(46)41-31(18-24-20-39-29-12-7-6-11-26(24)29)34(45)40-30(33(38)44)17-23-9-4-3-5-10-23/h3-7,9-12,15-16,20,28,30-32,39,43H,8,13-14,17-19,37H2,1-2H3,(H2,38,44)(H,40,45)(H,41,46)/t28-,30-,31-,32-/m0/s1
Affinity DataKi:  0.0540nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain P2 synaptosomeMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50049377(1-((S)-2-{(S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C1(CC1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(N)=O
Show InChI InChI=1S/C37H52N8O8/c1-20(2)29(34(51)40-19-28(39)47)43-35(52)30(21(3)4)44-36(53)37(15-16-37)45-33(50)27(18-23-9-7-6-8-10-23)42-31(48)22(5)41-32(49)26(38)17-24-11-13-25(46)14-12-24/h6-14,20-22,26-27,29-30,46H,15-19,38H2,1-5H3,(H2,39,47)(H,40,51)(H,41,49)(H,42,48)(H,43,52)(H,44,53)(H,45,50)/t22-,26-,27-,29-,30-/m0/s1
Affinity DataKi:  0.0540nMAssay Description:Displacement of [3H]-DPDPE (0.63 nM) from Opioid receptor delta 1More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272230(CHEMBL450566 | H-Dmt-Tic-Asp-NH-Bzl)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C32H36N4O6/c1-19-12-24(37)13-20(2)25(19)15-26(33)32(42)36-18-23-11-7-6-10-22(23)14-28(36)31(41)35-27(16-29(38)39)30(40)34-17-21-8-4-3-5-9-21/h3-13,26-28,37H,14-18,33H2,1-2H3,(H,34,40)(H,35,41)(H,38,39)/t26-,27-,28-/m0/s1
Affinity DataKi:  0.0540nMAssay Description:Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50083154((S)-2-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Show SMILES CNC(=O)[C@H](C)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C
Show InChI InChI=1S/C25H32N4O4/c1-14-9-19(30)10-15(2)20(14)12-21(26)25(33)29-13-18-8-6-5-7-17(18)11-22(29)24(32)28-16(3)23(31)27-4/h5-10,16,21-22,30H,11-13,26H2,1-4H3,(H,27,31)(H,28,32)/t16-,21-,22-/m0/s1
Affinity DataKi:  0.0580nMAssay Description:Binding affinity at Opioid receptor delta 1 from rat brain synaptosomal preparations by [3H]N,N-(Me)2-Dmt-Tic-OH displacement.More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272224(CHEMBL498799 | H-Dmt-Tic-D-Asp-NH-Ph)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CC(O)=O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C31H34N4O6/c1-18-12-23(36)13-19(2)24(18)15-25(32)31(41)35-17-21-9-7-6-8-20(21)14-27(35)30(40)34-26(16-28(37)38)29(39)33-22-10-4-3-5-11-22/h3-13,25-27,36H,14-17,32H2,1-2H3,(H,33,39)(H,34,40)(H,37,38)/t25-,26+,27-/m0/s1
Affinity DataKi:  0.0580nMAssay Description:Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50199865((S)-N-((S)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-y...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H42N6O5/c1-21-15-25(43)16-22(2)27(21)19-28(37)36(47)42-14-8-13-32(42)35(46)41-31(18-24-20-39-29-12-7-6-11-26(24)29)34(45)40-30(33(38)44)17-23-9-4-3-5-10-23/h3-7,9-12,15-16,20,28,30-32,39,43H,8,13-14,17-19,37H2,1-2H3,(H2,38,44)(H,40,45)(H,41,46)/t28-,30-,31-,32-/m0/s1
Affinity DataKi:  0.0590nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in human SHSY5Y cellsMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272227(CHEMBL450263 | H-Dmt-Tic-NH-(S)CH(CH2-COOH)-Bid(N1...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CC(O)=O)c1nc2ccccc2n1C
Show InChI InChI=1S/C32H35N5O5/c1-18-12-22(38)13-19(2)23(18)15-24(33)32(42)37-17-21-9-5-4-8-20(21)14-28(37)31(41)35-26(16-29(39)40)30-34-25-10-6-7-11-27(25)36(30)3/h4-13,24,26,28,38H,14-17,33H2,1-3H3,(H,35,41)(H,39,40)/t24-,26-,28-/m0/s1
Affinity DataKi:  0.0590nMAssay Description:Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50178759(1,6-bis-(N,N-dimethyl-Dmt-Tic-NH)hexane | CHEMBL37...)
Show SMILES CN(C)[C@@H](Cc1c(C)cc(O)cc1C)C(=O)N1Cc2ccccc2CC1C(=O)NCCCCCCNC(=O)C1Cc2ccccc2CN1C(=O)[C@H](Cc1c(C)cc(O)cc1C)N(C)C
Show InChI InChI=1S/C52H68N6O6/c1-33-23-41(59)24-34(2)43(33)29-47(55(5)6)51(63)57-31-39-19-13-11-17-37(39)27-45(57)49(61)53-21-15-9-10-16-22-54-50(62)46-28-38-18-12-14-20-40(38)32-58(46)52(64)48(56(7)8)30-44-35(3)25-42(60)26-36(44)4/h11-14,17-20,23-26,45-48,59-60H,9-10,15-16,21-22,27-32H2,1-8H3,(H,53,61)(H,54,62)/t45?,46?,47-,48-/m0/s1
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]deltorphin-II from delta opioid receptor in rat brain synaptosomal membranesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50157684(CHEMBL2369958 | H-Dmt-Tic-Glu-NH2)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCC(O)=O)C(N)=O
Show InChI InChI=1S/C26H32N4O6/c1-14-9-18(31)10-15(2)19(14)12-20(27)26(36)30-13-17-6-4-3-5-16(17)11-22(30)25(35)29-21(24(28)34)7-8-23(32)33/h3-6,9-10,20-22,31H,7-8,11-13,27H2,1-2H3,(H2,28,34)(H,29,35)(H,32,33)/t20-,21-,22-/m0/s1
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in rat brain synaptosomes P2 fractionMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50121645(2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)pr...)
Show SMILES C[C@H](NC(=O)C1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C30H33N5O3/c1-17-12-22(36)13-18(2)23(17)15-24(31)30(38)35-16-21-9-5-4-8-20(21)14-27(35)29(37)32-19(3)28-33-25-10-6-7-11-26(25)34-28/h4-13,19,24,27,36H,14-16,31H2,1-3H3,(H,32,37)(H,33,34)/t19-,24-,27?/m0/s1
Affinity DataKi:  0.0630nMAssay Description:Inhibition of [3H]DPDPE binding to Opioid receptor delta 1 of rat brain P2 synaptosomesMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50159681((S)-1-[2-Amino-3-(2-ethyl-4-hydroxy-6-methyl-pheny...)
Show SMILES CCc1cc(O)cc(C)c1CC(N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C35H43N5O5/c1-3-25-20-26(41)17-22(2)27(25)21-28(36)35(45)40-16-10-15-31(40)34(44)39-30(19-24-13-8-5-9-14-24)33(43)38-29(32(37)42)18-23-11-6-4-7-12-23/h4-9,11-14,17,20,28-31,41H,3,10,15-16,18-19,21,36H2,1-2H3,(H2,37,42)(H,38,43)(H,39,44)/t28?,29-,30-,31-/m0/s1
Affinity DataKi:  0.0630nMAssay Description:Inhibition of [3H]-DAMGO binding to mu-Opioid receptorMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50297287((S)-1H-benzo[d]imidazol-2-yl 2-((S)-2-((S)-2-amino...)
Show SMILES C[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C31H33N5O4/c1-17-12-22(37)13-18(2)23(17)15-24(32)31(40)36-16-21-9-5-4-8-20(21)14-27(36)30(39)33-19(3)28(38)29-34-25-10-6-7-11-26(25)35-29/h4-13,19,24,27,37H,14-16,32H2,1-3H3,(H,33,39)(H,34,35)/t19-,24-,27-/m0/s1
Affinity DataKi:  0.0630nMAssay Description:Displacement of [3H]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50297297((S)-1H-benzo[d]imidazol-2-yl 2-((S)-2-((S)-2-amino...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N[N+]([O-])=O)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C34H39N9O6/c1-19-14-23(44)15-20(2)24(19)17-25(35)33(47)42-18-22-9-4-3-8-21(22)16-29(42)32(46)40-28(12-7-13-37-34(36)41-43(48)49)30(45)31-38-26-10-5-6-11-27(26)39-31/h3-6,8-11,14-15,25,28-29,44H,7,12-13,16-18,35H2,1-2H3,(H,38,39)(H,40,46)(H3,36,37,41)/t25-,28-,29-/m0/s1
Affinity DataKi:  0.0650nMAssay Description:Displacement of [3H]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50375294(CHEMBL408975)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1cc2ccccc2[nH]1
Show InChI InChI=1S/C30H32N4O3/c1-18-11-24(35)12-19(2)25(18)15-26(31)30(37)34-17-22-9-4-3-7-20(22)14-28(34)29(36)32-16-23-13-21-8-5-6-10-27(21)33-23/h3-13,26,28,33,35H,14-17,31H2,1-2H3,(H,32,36)/t26-,28-/m0/s1
Affinity DataKi:  0.0660nMAssay Description:Binding affinity to delta opioid receptor in Sprague-Dawley rat brain membraneMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50083169((S)-2-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Show SMILES C[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)NC(C)(C)C
Show InChI InChI=1S/C28H38N4O4/c1-16-11-21(33)12-17(2)22(16)14-23(29)27(36)32-15-20-10-8-7-9-19(20)13-24(32)26(35)30-18(3)25(34)31-28(4,5)6/h7-12,18,23-24,33H,13-15,29H2,1-6H3,(H,30,35)(H,31,34)/t18-,23-,24-/m0/s1
Affinity DataKi:  0.0660nMAssay Description:Binding affinity at Opioid receptor delta 1 from rat brain synaptosomal preparations by [3H]N,N-(Me)2-Dmt-Tic-OH displacement.More data for this Ligand-Target Pair
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