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TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101410((trans,trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101411(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100131(5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101413(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.190nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50101412(5-[2-bromo-4-(3-carboxy-4-hydroxyphenethyl)pheneth...)
Affinity DataKi:  0.270nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50100130(4-(6-Iodobenzo[d]thiazol-2-yl)-N,N-dimethylaniline...)
Affinity DataKi:  0.900nMAssay Description:Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310131((2-hydroxy-4-(3-isobutyl-5-methylhexylidene)-5-oxo...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310107((E)-(2-(hydroxymethyl)-4-(8-(nonyloxy)octylidene)-...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM107767(US11419874, PF-05180999 | US8598155, 2)
Affinity DataKi:  4.20nMAssay Description:Displacement of radiolabeled 4-(azetidin-1-yl)-3-[5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-1-(tritritiomethyl)pyrazolo[3,4-d]pyrimidine from PD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310104((E)-(2-(hydroxymethyl)-4-(16-methoxyhexadecylidene...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310105((Z)-(2-(hydroxymethyl)-4-(16-methoxyhexadecylidene...)
Affinity DataKi:  5nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310120((E)-(2-(hydroxymethyl)-5-oxo-4-(16-oxohexadecylide...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310115((E)-(4-(16-hydroxyhexadecylidene)-2-(hydroxymethyl...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310124((E)-methyl 16-(5-(hydroxymethyl)-2-oxo-5-(pivaloyl...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310101((Z)-(2-(hydroxymethyl)-5-oxo-4-tetradecylidenetetr...)
Affinity DataKi:  7.20nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310112((E)-(2-(hydroxymethyl)-4-(4-(nonyloxy)butylidene)-...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310110((E)-(2-(hydroxymethyl)-4-(8-(isopentyloxy)octylide...)
Affinity DataKi:  7.70nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310100((E)-(2-(hydroxymethyl)-5-oxo-4-tetradecylidenetetr...)
Affinity DataKi:  7.80nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310125((E)-(4-(16-(formyloxy)hexadecylidene)-2-(hydroxyme...)
Affinity DataKi:  8nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240692(CHEMBL4078588)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]PT-1284 human muscarinic acetylcholine receptor M1 expressed in CHO cell membranes after 90 mins scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310106((E)-(2-(hydroxymethyl)-5-oxo-4-(8-(pentyloxy)octyl...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310103((E)-(2-(hydroxymethyl)-4-(12-methoxydodecylidene)-...)
Affinity DataKi:  8.20nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310116((Z)-(4-(16-hydroxyhexadecylidene)-2-(hydroxymethyl...)
Affinity DataKi:  8.20nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310130((E)-(4-(16-acetamidohexadecylidene)-2-(hydroxymeth...)
Affinity DataKi:  8.30nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310126((E)-(4-(16-acetoxyhexadecylidene)-2-(hydroxymethyl...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310111((E)-(4-(8-(cyclopentyloxy)octylidene)-2-(hydroxyme...)
Affinity DataKi:  10nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50122785(4-(6-bromoH-imidazo[1,2-a]pyridin-2-yl)-N,N-dimeth...)
Affinity DataKi:  10.3nMAssay Description:Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310121((Z)-(2-(hydroxymethyl)-5-oxo-4-(16-oxohexadecylide...)
Affinity DataKi:  11nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310127((E)-16-(5-(hydroxymethyl)-2-oxo-5-(pivaloyloxymeth...)
Affinity DataKi:  11nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310114((E)-(4-(12-hydroxydodecylidene)-2-(hydroxymethyl)-...)
Affinity DataKi:  15nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50122787(2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyr...)
Affinity DataKi:  15nMAssay Description:Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240694(CHEMBL4067722)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]PT-1284 human muscarinic acetylcholine receptor M1 expressed in CHO cell membranes after 90 mins scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310128((E)-(4-(16-azidohexadecylidene)-2-(hydroxymethyl)-...)
Affinity DataKi:  16nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240693(CHEMBL4097569)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]PT-1284 human muscarinic acetylcholine receptor M1 expressed in CHO cell membranes after 90 mins scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310122((E)-16-(5-(hydroxymethyl)-2-oxo-5-(pivaloyloxymeth...)
Affinity DataKi:  30nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310119((E)-(2-(hydroxymethyl)-5-oxo-4-(12-oxododecylidene...)
Affinity DataKi:  30nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310129((E)-(4-(16-aminohexadecylidene)-2-(hydroxymethyl)-...)
Affinity DataKi:  36nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310118((E)-(2-(hydroxymethyl)-5-oxo-4-(8-oxooctylidene)te...)
Affinity DataKi:  39nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50135213(CHEMBL3747016)
Affinity DataKi:  40nMAssay Description:In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310117((E)-(4-(8-hydroxyhexadecylidene)-2-(hydroxymethyl)...)
Affinity DataKi:  118nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310102((E)-(2-(hydroxymethyl)-4-(8-methoxyoctylidene)-5-o...)
Affinity DataKi:  191nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310108((E)-(2-(hydroxymethyl)-4-(8-(methoxymethoxy)octyli...)
Affinity DataKi:  198nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50122784(CHEMBL78621 | Dimethyl-[4-(6-methyl-imidazo[1,2-a]...)
Affinity DataKi:  242nMAssay Description:Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310109((E)-(2-(hydroxymethyl)-4-(8-((2-methoxyethoxy)meth...)
Affinity DataKi:  323nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50122789(CHEMBL309920 | [2-(4-Bromo-phenyl)-imidazo[1,2-a]p...)
Affinity DataKi:  339nMAssay Description:Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310113((E)-(2-(hydroxymethyl)-4-(8-hydroxyoctylidene)-5-o...)
Affinity DataKi:  378nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50310123((E)-methyl 8-(5-(hydroxymethyl)-2-oxo-5-(pivaloylo...)
Affinity DataKi:  533nMAssay Description:Displacement of [20-3H]phorbol 12,13-dibutyrate from recombinant PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50122788(2-(4-Bromo-phenyl)-6-methyl-imidazo[1,2-a]pyridine...)
Affinity DataKi:  638nMAssay Description:Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50122782((4-Imidazo[1,2-a]pyridin-2-yl-phenyl)-methyl-amine...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition constant against [125I]-7 (TZDM) binding to Amyloid beta 1-40 aggregatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM26193(2-Hydroxybenzoate, I | 2-hydroxybenzoic acid | CHE...)
Affinity DataKi: >1.80E+3nMAssay Description:Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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