Report error Found 1078 with Last Name = 'lee' and Initial = 'hj'
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataKd: 0.0154nMAssay Description:Binding affinity to FLT3 ITD/F691L double mutant (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataKd: <0.25nMAssay Description:Binding affinity to human FLT3 ITD mutant in presence of ATP by Lanthascreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.25nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.290nMAssay Description:Inhibition of FLT3 expressed in human SEMK2 cells assessed as reduction in FLT3 phosphorylation incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human FLT3 D835Y mutant in presence of ATPMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology
Curated by ChEMBL
Korea Institute of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.339nMAssay Description:Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology
Curated by ChEMBL
Korea Institute of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.340nMAssay Description:Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.390nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.520nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at human MR expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.640nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.670nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.690nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.75nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
National Health Research Institutes
Curated by ChEMBL
National Health Research Institutes
Curated by ChEMBL
Affinity DataEC50: 0.780nMAssay Description:Effect on Gal4/PPAR-gamma-LBD construct transactivation in Huh7 cellsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Agonist activity at human RAR-beta expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.870nMAssay Description:Inhibition of recombinant His-tagged human FLT3 expressed in baculovirus expression system using peptide substrate incubated for 30 mins in presence ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.880nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology
Curated by ChEMBL
Korea Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human 11beta-HSD1 using microsomal fraction and NADPH assessed as conversion of cortisone to cortisol by biochemical enzyme assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.930nMAssay Description:Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology
Curated by ChEMBL
Korea Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.933nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Human)
Ewha Womans University
Curated by ChEMBL
Ewha Womans University
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Agonist activity at human PPAR-alpha expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human PR-beta expressed in U2OS cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human PR-alpha expressed in U2OS cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human RAR-alpha expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Human)
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by H...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Human)
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataEC50: 1.10nMAssay Description:Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology
Curated by ChEMBL
Gwangju Institute of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells preincubated for 2 hrs followed by FLT3 ligand addition and measured after 15 minsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Human)
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataEC50: 1.10nMAssay Description:Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Human)
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataEC50: 1.20nMAssay Description:Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair










3D Structure (crystal)




















