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Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458550(CHEMBL4209274)
Affinity DataEC50:  188nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458550(CHEMBL4209274)
Affinity DataEC50:  186nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458558(CHEMBL4210782)
Affinity DataEC50:  166nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458557(CHEMBL4215875)
Affinity DataEC50:  41nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458558(CHEMBL4210782)
Affinity DataEC50:  165nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458553(CHEMBL4218672)
Affinity DataEC50:  135nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458557(CHEMBL4215875)
Affinity DataEC50:  41nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458555(CHEMBL4207884)
Affinity DataEC50:  162nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458553(CHEMBL4218672)
Affinity DataEC50:  135nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458555(CHEMBL4207884)
Affinity DataEC50:  162nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458554(CHEMBL4218801)
Affinity DataEC50:  112nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458554(CHEMBL4218801)
Affinity DataEC50:  113nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50017702(cid_6365505 | 1-(bis(4-fluorophenyl)methyl)-4-cinn...)
Affinity DataKd:  530nMAssay Description:Binding affinity to T-type alpha1G calcium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50017702(cid_6365505 | 1-(bis(4-fluorophenyl)methyl)-4-cinn...)
Affinity DataKd:  840nMAssay Description:Binding affinity to T-type alpha1I calcium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataKd:  40nMAssay Description:Inhibition of T-type alpha1G calcium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585092(CHEMBL5087577)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364573(CHEMBL1951143)
Affinity DataIC50: 0.420nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50428286(GSK2118436A | DABRAFENIB)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataIC50: 0.933nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364587(CHEMBL1951136)
Affinity DataIC50: 1.03nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585092(CHEMBL5087577)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50560548(CHEMBL4795335)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364574(CHEMBL1951144)
Affinity DataIC50: 1.31nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254040(US9493430, 593)
Affinity DataIC50: 1.5nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585085(CHEMBL5080553)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364580(CHEMBL1951129)
Affinity DataIC50: 1.58nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254048(US9493430, 618)
Affinity DataIC50: 1.60nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details
Go to US Patent

TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364586(CHEMBL1951135)
Affinity DataIC50: 1.75nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254050(US9493430, 631)
Affinity DataIC50: 1.90nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details
Go to US Patent

TargetCholesteryl ester transfer protein(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254058(US9493430, 684)
Affinity DataIC50: 1.90nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM193503(US9199944, 85)
Affinity DataIC50: 2nMT: 2°CAssay Description:In order to measure the inhibitory activity against ALK, a Grainer 96-well round type bottom plate was added with the compounds (2 μl) prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM193475(US9199944, 57)
Affinity DataIC50: 2nMT: 2°CAssay Description:In order to measure the inhibitory activity against ALK, a Grainer 96-well round type bottom plate was added with the compounds (2 μl) prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM193476(US9199944, 58)
Affinity DataIC50: 2nMT: 2°CAssay Description:In order to measure the inhibitory activity against ALK, a Grainer 96-well round type bottom plate was added with the compounds (2 μl) prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585092(CHEMBL5087577)
Affinity DataIC50: 2nMAssay Description:Inhibition of human wild type BRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585095(CHEMBL5079413)
Affinity DataIC50: 2nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364581(CHEMBL1951130)
Affinity DataIC50: 2.06nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364582(CHEMBL1951131)
Affinity DataIC50: 2.08nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585088(CHEMBL5073246)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364577(CHEMBL1951126)
Affinity DataIC50: 2.37nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364583(CHEMBL1951132)
Affinity DataIC50: 2.46nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandPNGBDBM254054(US9493430, 661)
Affinity DataIC50: 2.5nMAssay Description:As a protein source for cholesteryl ester transfer, plasma from healthy persons was used, and as a cholesteryl ester receptor, LDL from healthy perso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585085(CHEMBL5080553)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364590(CHEMBL1951120)
Affinity DataIC50: 2.51nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585088(CHEMBL5073246)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50364593(CHEMBL1951123)
Affinity DataIC50: 2.63nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
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