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TargetAndrogen receptor(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced lu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50427619(CHEMBL2323511 | US9346803, 3)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced lu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50427620(CHEMBL2323507 | US9346803, 2)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced lu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50427621(CHEMBL2323490 | US9346803, 1)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced lu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427622(CHEMBL2323508 | US9346803, Table 2, Compound 10: 3...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427628(CHEMBL2323472 | US9346803, Table 2, Compound 8: 2-...)
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427620(CHEMBL2323507 | US9346803, 2)
Affinity DataIC50: 0.130nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427629(CHEMBL179587 | US9346803, Table 2, Compound 7: 2-[...)
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427624(CHEMBL2323522 | US9346803, Table 2, Compound 11: 9...)
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427621(CHEMBL2323490 | US9346803, 1)
Affinity DataIC50: 0.210nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427625(CHEMBL178687 | US9346803, Table 2, Compound 6: 3-[...)
Affinity DataIC50: 0.220nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427627(CHEMBL2323474 | US9346803, Table 2, Compound 9: 2-...)
Affinity DataIC50: 0.270nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427619(CHEMBL2323511 | US9346803, 3)
Affinity DataIC50: 0.340nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427626(CHEMBL2323481 | US9346803, Table 2, Compound 5: 2-...)
Affinity DataIC50: 0.740nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50293598(2'-des-methyl indomethacin | CHEMBL503179 | US9346...)
Affinity DataIC50: 0.960nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427622(CHEMBL2323508 | US9346803, Table 2, Compound 10: 3...)
Affinity DataIC50: 1.95nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251993(trans-4-{4-[4-(4-Fluoro-phenyl)-3-(2-methoxy-ethyl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251932(trans-4-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1...)
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427624(CHEMBL2323522 | US9346803, Table 2, Compound 11: 9...)
Affinity DataIC50: 3.15nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427620(CHEMBL2323507 | US9346803, 2)
Affinity DataIC50: 3.51nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251985(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5...)
Affinity DataIC50: 5nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251981(2-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imid...)
Affinity DataIC50: 6nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251972(((R)-1-Cyclohexyl-ethyl)-{4-[4-(4-fluoro-phenyl)-2...)
Affinity DataIC50: 9nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Vanderbilt Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50: 9nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251982(2-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251978((1,2-Dimethyl-propyl)-{4-[4-(4-fluoro-phenyl)-2-me...)
Affinity DataIC50: 11nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251921(trans-4-{4-[2-Methylsulfanyl-4-(3-trifluoromethyl-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES1 in IL1-beta treated human A549 cell microsomal membrane assessed as residual enzyme activity after 1 min by measuring PGE2 level...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427619(CHEMBL2323511 | US9346803, 3)
Affinity DataIC50: 12.6nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251975((cis/trans) -{4-[4-(4-Fluoro-phenyl)-2-methylsulfa...)
Affinity DataIC50: 13nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50252665({4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidaz...)
Affinity DataIC50: 13nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C2(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427620(CHEMBL2323507 | US9346803, 2)
Affinity DataIC50: 14.5nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251984(3-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imid...)
Affinity DataIC50: 15nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251924(trans-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50252664({4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidaz...)
Affinity DataIC50: 17nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427620(CHEMBL2323507 | US9346803, 2)
Affinity DataIC50: 17.7nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251927((1,5-Dimethyl-hexyl)-{4-[4-(4-fluoro-phenyl)-2-met...)
Affinity DataIC50: 20nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251925((cis/trans)-{4-[4-(4-Fluoro-phenyl)-2-methylsulfan...)
Affinity DataIC50: 20nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251974(Cyclohexyl-{4-[4-(4-fluoro-phenyl)-2-methylsulfany...)
Affinity DataIC50: 20nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Vanderbilt Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 20nMAssay Description:Inhibition of COX1 (unknown origin)-mediated oxidation of N,N,N,Ntetramethyl-1,4-phenylenediamine using arachidonic acid as substrate by colorimetric...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251929(1-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imid...)
Affinity DataIC50: 21nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251926({4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidaz...)
Affinity DataIC50: 23nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251912({4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidaz...)
Affinity DataIC50: 23nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataIC50: 26nMAssay Description:Binding affinity to FLAPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251980((1,3-Dimethyl-butyl)-{4-[4-(4-fluoro-phenyl)-2-met...)
Affinity DataIC50: 26nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50252617({4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidaz...)
Affinity DataIC50: 28nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50427622(CHEMBL2323508 | US9346803, Table 2, Compound 10: 3...)
Affinity DataIC50: 30.7nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251923(cis-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-im...)
Affinity DataIC50: 31nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251935(4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidazo...)
Affinity DataIC50: 33nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50251983(2-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imid...)
Affinity DataIC50: 34nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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