Compile Data Set for Download or QSAR
Found 318 with Last Name = 'little' and Initial = 'pb'
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Show SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Show SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28)
Affinity DataIC50: 0.610nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Show SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28)
Affinity DataIC50: 0.870nMAssay Description:Inhibitory concentration against histamine H2 receptorMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172441((E)-N-{2-[(2-Hydroxy-ethyl)-methyl-amino]-4-methyl...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C23H22F3N3O3/c1-15-13-21(29(2)11-12-30)28-20-9-6-17(14-19(15)20)27-22(31)10-5-16-3-7-18(8-4-16)32-23(24,25)26/h3-10,13-14,30H,11-12H2,1-2H3,(H,27,31)/b10-5+
Affinity DataIC50: 0.900nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177292(CHEMBL425407 | N-(4-methyl-2-(2-(piperidin-1-yl)et...)
Show SMILES Cc1cc(NCCN2CCCCC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C26H29F3N4O3/c1-18-15-24(30-11-14-33-12-3-2-4-13-33)32-23-10-5-19(16-22(18)23)31-25(34)17-35-20-6-8-21(9-7-20)36-26(27,28)29/h5-10,15-16H,2-4,11-14,17H2,1H3,(H,30,32)(H,31,34)
Affinity DataIC50: 0.910nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172429(CHEMBL370120 | N-(4-Methyl-2-piperidin-1-yl-quinol...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCCCC1
Show InChI InChI=1S/C24H24F3N3O3/c1-16-13-22(30-11-3-2-4-12-30)29-21-10-5-17(14-20(16)21)28-23(31)15-32-18-6-8-19(9-7-18)33-24(25,26)27/h5-10,13-14H,2-4,11-12,15H2,1H3,(H,28,31)
Affinity DataIC50: 0.920nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Show SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28)
Affinity DataIC50: 1.30nMAssay Description:Inhibitory concentration against dopamine receptor D3More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177299(CHEMBL204952 | N-(4-methyl-2-(2-morpholinoethylami...)
Show SMILES Cc1cc(NCCN2CCOCC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C25H27F3N4O4/c1-17-14-23(29-8-9-32-10-12-34-13-11-32)31-22-7-2-18(15-21(17)22)30-24(33)16-35-19-3-5-20(6-4-19)36-25(26,27)28/h2-7,14-15H,8-13,16H2,1H3,(H,29,31)(H,30,33)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172425(CHEMBL197026 | N-[2-(4-Amino-piperidin-1-yl)-4-met...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(N)CC1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-12-22(31-10-8-16(28)9-11-31)30-21-7-2-17(13-20(15)21)29-23(32)14-33-18-3-5-19(6-4-18)34-24(25,26)27/h2-7,12-13,16H,8-11,14,28H2,1H3,(H,29,32)
Affinity DataIC50: 1.5nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172418(CHEMBL195635 | N-[4-Methyl-2-(4-pyrrolidin-1-yl-pi...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C28H31F3N4O3/c1-19-16-26(35-14-10-21(11-15-35)34-12-2-3-13-34)33-25-9-4-20(17-24(19)25)32-27(36)18-37-22-5-7-23(8-6-22)38-28(29,30)31/h4-9,16-17,21H,2-3,10-15,18H2,1H3,(H,32,36)
Affinity DataIC50: 1.5nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172424(CHEMBL198361 | N-(4-Methyl-2-morpholin-4-yl-quinol...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCOCC1
Show InChI InChI=1S/C23H22F3N3O4/c1-15-12-21(29-8-10-31-11-9-29)28-20-7-2-16(13-19(15)20)27-22(30)14-32-17-3-5-18(6-4-17)33-23(24,25)26/h2-7,12-13H,8-11,14H2,1H3,(H,27,30)
Affinity DataIC50: 1.60nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Show SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177291(CHEMBL205111 | N-(2-(4-(2-hydroxyethyl)piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCN(CCO)CC1
Show InChI InChI=1S/C25H27F3N4O4/c1-17-14-23(32-10-8-31(9-11-32)12-13-33)30-22-7-2-18(15-21(17)22)29-24(34)16-35-19-3-5-20(6-4-19)36-25(26,27)28/h2-7,14-15,33H,8-13,16H2,1H3,(H,29,34)
Affinity DataIC50: 1.70nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172416(CHEMBL427540 | N-[2-(2,5-Diaza-bicyclo[2.2.1]hept-...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CC2CC1CN2
Show InChI InChI=1S/C24H23F3N4O3/c1-14-8-22(31-12-16-9-17(31)11-28-16)30-21-7-2-15(10-20(14)21)29-23(32)13-33-18-3-5-19(6-4-18)34-24(25,26)27/h2-8,10,16-17,28H,9,11-13H2,1H3,(H,29,32)
Affinity DataIC50: 1.90nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177279(CHEMBL436320 | N-(2-(1,4-diazepan-1-yl)-4-methylqu...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCCNCC1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-2-9-28-10-12-31)30-21-8-3-17(14-20(16)21)29-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14,28H,2,9-12,15H2,1H3,(H,29,32)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172415(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-m...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H21Cl2N3O3/c1-13-9-20(26(2)7-8-27)25-18-5-4-15(11-16(13)18)24-21(28)12-29-19-6-3-14(22)10-17(19)23/h3-6,9-11,27H,7-8,12H2,1-2H3,(H,24,28)
Affinity DataIC50: 2.10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50150073(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
Affinity DataIC50: 2.30nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50150073(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172444((E)-N-[2-(4-Ethyl-piperazin-1-yl)-4-methyl-quinoli...)
Show SMILES CCN1CCN(CC1)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H27F3N4O2/c1-3-32-12-14-33(15-13-32)24-16-18(2)22-17-20(7-10-23(22)31-24)30-25(34)11-6-19-4-8-21(9-5-19)35-26(27,28)29/h4-11,16-17H,3,12-15H2,1-2H3,(H,30,34)/b11-6+
Affinity DataIC50: 2.30nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177281(CHEMBL379693 | N-(2-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H27F3N4O3/c1-16-13-22(31(4)12-11-30(2)3)29-21-10-5-17(14-20(16)21)28-23(32)15-33-18-6-8-19(9-7-18)34-24(25,26)27/h5-10,13-14H,11-12,15H2,1-4H3,(H,28,32)
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172434(Acetic acid 2-({6-[2-(3,4-dichloro-phenoxy)-acetyl...)
Show SMILES CN(CCOC(C)=O)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H23Cl2N3O4/c1-14-10-22(28(3)8-9-31-15(2)29)27-20-6-5-17(12-18(14)20)26-23(30)13-32-21-7-4-16(24)11-19(21)25/h4-7,10-12H,8-9,13H2,1-3H3,(H,26,30)
Affinity DataIC50: 2.30nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177285(CHEMBL204428 | rac-N-(2-(3-(dimethylamino)pyrrolid...)
Show SMILES CN(C)C1CCN(C1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-16-12-23(32-11-10-18(14-32)31(2)3)30-22-9-4-17(13-21(16)22)29-24(33)15-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-9,12-13,18H,10-11,14-15H2,1-3H3,(H,29,33)
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172427(CHEMBL196581 | N-[2-(3-Dimethylamino-propylamino)-...)
Show SMILES CN(C)CCCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H27F3N4O3/c1-16-13-22(28-11-4-12-31(2)3)30-21-10-5-17(14-20(16)21)29-23(32)15-33-18-6-8-19(9-7-18)34-24(25,26)27/h5-10,13-14H,4,11-12,15H2,1-3H3,(H,28,30)(H,29,32)
Affinity DataIC50: 2.70nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172442((E)-N-[2-(2-Dimethylamino-ethylamino)-4-methyl-qui...)
Show SMILES CN(C)CCNc1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O2/c1-16-14-22(28-12-13-31(2)3)30-21-10-7-18(15-20(16)21)29-23(32)11-6-17-4-8-19(9-5-17)33-24(25,26)27/h4-11,14-15H,12-13H2,1-3H3,(H,28,30)(H,29,32)/b11-6+
Affinity DataIC50: 3nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177287(CHEMBL203586 | N-(2-(2-(diethylamino)ethylamino)-4...)
Show SMILES CCN(CC)CCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H29F3N4O3/c1-4-32(5-2)13-12-29-23-14-17(3)21-15-18(6-11-22(21)31-23)30-24(33)16-34-19-7-9-20(10-8-19)35-25(26,27)28/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H,29,31)(H,30,33)
Affinity DataIC50: 3.20nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172425(CHEMBL197026 | N-[2-(4-Amino-piperidin-1-yl)-4-met...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(N)CC1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-12-22(31-10-8-16(28)9-11-31)30-21-7-2-17(13-20(15)21)29-23(32)14-33-18-3-5-19(6-4-18)34-24(25,26)27/h2-7,12-13,16H,8-11,14,28H2,1H3,(H,29,32)
Affinity DataIC50: 3.5nMAssay Description:Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Show SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28)
Affinity DataIC50: 3.5nMAssay Description:Inhibitory concentration against histamine H1 receptorMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177293(CHEMBL202095 | N-(4-methyl-2-(4-methyl-1,4-diazepa...)
Show SMILES CN1CCCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-17-14-23(32-11-3-10-31(2)12-13-32)30-22-9-4-18(15-21(17)22)29-24(33)16-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-9,14-15H,3,10-13,16H2,1-2H3,(H,29,33)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 2(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172440(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12)N1CCNCC1
Show InChI InChI=1S/C22H22Cl2N4O2/c1-14-10-21(28-8-6-25-7-9-28)27-19-4-3-16(12-17(14)19)26-22(29)13-30-20-5-2-15(23)11-18(20)24/h2-5,10-12,25H,6-9,13H2,1H3,(H,26,29)
Affinity DataIC50: 3.70nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177273((S)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin...)
Show SMILES C[C@H]1CN(CCN1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-11-22(31-10-9-28-16(2)13-31)30-21-8-3-17(12-20(15)21)29-23(32)14-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,11-12,16,28H,9-10,13-14H2,1-2H3,(H,29,32)/t16-/m0/s1
Affinity DataIC50: 3.70nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172427(CHEMBL196581 | N-[2-(3-Dimethylamino-propylamino)-...)
Show SMILES CN(C)CCCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H27F3N4O3/c1-16-13-22(28-11-4-12-31(2)3)30-21-10-5-17(14-20(16)21)29-23(32)15-33-18-6-8-19(9-7-18)34-24(25,26)27/h5-10,13-14H,4,11-12,15H2,1-3H3,(H,28,30)(H,29,32)
Affinity DataIC50: 3.80nMAssay Description:Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172430((E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-...)
Show SMILES Cc1cc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCNCC1
Show InChI InChI=1S/C24H23F3N4O2/c1-16-14-22(31-12-10-28-11-13-31)30-21-8-5-18(15-20(16)21)29-23(32)9-4-17-2-6-19(7-3-17)33-24(25,26)27/h2-9,14-15,28H,10-13H2,1H3,(H,29,32)/b9-4+
Affinity DataIC50: 4nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177296((R)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin...)
Show SMILES C[C@@H]1CN(CCN1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-11-22(31-10-9-28-16(2)13-31)30-21-8-3-17(12-20(15)21)29-23(32)14-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,11-12,16,28H,9-10,13-14H2,1-2H3,(H,29,32)/t16-/m1/s1
Affinity DataIC50: 4.10nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172426((E)-N-[2-(2-Dimethylamino-1-methyl-ethylamino)-4-m...)
Show SMILES CC(CN(C)C)Nc1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O2/c1-16-13-23(29-17(2)15-32(3)4)31-22-11-8-19(14-21(16)22)30-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-14,17H,15H2,1-4H3,(H,29,31)(H,30,33)/b12-7+
Affinity DataIC50: 4.30nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Show SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28)
Affinity DataIC50: 4.5nMAssay Description:Inhibitory concentration against muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 2(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172432(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-et...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H26Cl2N4O2/c1-15-11-22(29(4)10-9-28(2)3)27-20-7-6-17(13-18(15)20)26-23(30)14-31-21-8-5-16(24)12-19(21)25/h5-8,11-13H,9-10,14H2,1-4H3,(H,26,30)
Affinity DataIC50: 4.5nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 2(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172425(CHEMBL197026 | N-[2-(4-Amino-piperidin-1-yl)-4-met...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(N)CC1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-12-22(31-10-8-16(28)9-11-31)30-21-7-2-17(13-20(15)21)29-23(32)14-33-18-3-5-19(6-4-18)34-24(25,26)27/h2-7,12-13,16H,8-11,14,28H2,1H3,(H,29,32)
Affinity DataIC50: 4.70nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177280(CHEMBL203699 | N-(2-(3-(dimethylamino)-2,2-dimethy...)
Show SMILES CN(C)CC(C)(C)CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H31F3N4O3/c1-17-12-23(30-15-25(2,3)16-33(4)5)32-22-11-6-18(13-21(17)22)31-24(34)14-35-19-7-9-20(10-8-19)36-26(27,28)29/h6-13H,14-16H2,1-5H3,(H,30,32)(H,31,34)
Affinity DataIC50: 4.70nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172440(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12)N1CCNCC1
Show InChI InChI=1S/C22H22Cl2N4O2/c1-14-10-21(28-8-6-25-7-9-28)27-19-4-3-16(12-17(14)19)26-22(29)13-30-20-5-2-15(23)11-18(20)24/h2-5,10-12,25H,6-9,13H2,1H3,(H,26,29)
Affinity DataIC50: 5nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177291(CHEMBL205111 | N-(2-(4-(2-hydroxyethyl)piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCN(CCO)CC1
Show InChI InChI=1S/C25H27F3N4O4/c1-17-14-23(32-10-8-31(9-11-32)12-13-33)30-22-7-2-18(15-21(17)22)29-24(34)16-35-19-3-5-20(6-4-19)36-25(26,27)28/h2-7,14-15,33H,8-13,16H2,1H3,(H,29,34)
Affinity DataIC50: 5nMAssay Description:Inhibition of human MCH1 receptor by SPA assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172441((E)-N-{2-[(2-Hydroxy-ethyl)-methyl-amino]-4-methyl...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C23H22F3N3O3/c1-15-13-21(29(2)11-12-30)28-20-9-6-17(14-19(15)20)27-22(31)10-5-16-3-7-18(8-4-16)32-23(24,25)26/h3-10,13-14,30H,11-12H2,1-2H3,(H,27,31)/b10-5+
Affinity DataIC50: 5.20nMAssay Description:Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositolMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50153217(CHEMBL425359 | N-(2-Diethylamino-ethyl)-4-[3-(4-tr...)
Show SMILES CCN(CC)CCNC(=O)c1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H25F3N4O2/c1-3-28(4-2)14-13-25-19(29)15-5-9-17(10-6-15)26-20(30)27-18-11-7-16(8-12-18)21(22,23)24/h5-12H,3-4,13-14H2,1-2H3,(H,25,29)(H2,26,27,30)
Affinity DataIC50: 5.30nMAssay Description:Binding affinity against human Melanin-concentrating hormone receptor 1 stably transfected CHO cells was determined using [125I]-MCH as radioligandMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177292(CHEMBL425407 | N-(4-methyl-2-(2-(piperidin-1-yl)et...)
Show SMILES Cc1cc(NCCN2CCCCC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
Show InChI InChI=1S/C26H29F3N4O3/c1-18-15-24(30-11-14-33-12-3-2-4-13-33)32-23-10-5-19(16-22(18)23)31-25(34)17-35-20-6-8-21(9-7-20)36-26(27,28)29/h5-10,15-16H,2-4,11-14,17H2,1H3,(H,30,32)(H,31,34)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human MCH1 receptor by SPA assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177300(CHEMBL379886 | N-(2-(2-(dimethylamino)ethylamino)-...)
Show SMILES CN(C)CCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C23H25F3N4O3/c1-15-12-21(27-10-11-30(2)3)29-20-9-4-16(13-19(15)20)28-22(31)14-32-17-5-7-18(8-6-17)33-23(24,25)26/h4-9,12-13H,10-11,14H2,1-3H3,(H,27,29)(H,28,31)
Affinity DataIC50: 5.30nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172443(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-morpholin-4...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12)N1CCOCC1
Show InChI InChI=1S/C22H21Cl2N3O3/c1-14-10-21(27-6-8-29-9-7-27)26-19-4-3-16(12-17(14)19)25-22(28)13-30-20-5-2-15(23)11-18(20)24/h2-5,10-12H,6-9,13H2,1H3,(H,25,28)
Affinity DataIC50: 5.5nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177284(CHEMBL442794 | biphenyl-4-carboxylic acid {2-[(2-d...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)c3ccc(cc3)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C28H30N4O/c1-20-18-27(32(4)17-16-31(2)3)30-26-15-14-24(19-25(20)26)29-28(33)23-12-10-22(11-13-23)21-8-6-5-7-9-21/h5-15,18-19H,16-17H2,1-4H3,(H,29,33)
Affinity DataIC50: 5.70nMAssay Description:Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172432(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-et...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H26Cl2N4O2/c1-15-11-22(29(4)10-9-28(2)3)27-20-7-6-17(13-18(15)20)26-23(30)14-31-21-8-5-16(24)12-19(21)25/h5-8,11-13H,9-10,14H2,1-4H3,(H,26,30)
Affinity DataIC50: 5.90nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172436((E)-N-(2-[1,4]Diazepan-1-yl-4-methyl-quinolin-6-yl...)
Show SMILES Cc1cc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCCNCC1
Show InChI InChI=1S/C25H25F3N4O2/c1-17-15-23(32-13-2-11-29-12-14-32)31-22-9-6-19(16-21(17)22)30-24(33)10-5-18-3-7-20(8-4-18)34-25(26,27)28/h3-10,15-16,29H,2,11-14H2,1H3,(H,30,33)/b10-5+
Affinity DataIC50: 6.10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172413(2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...)
Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)
Affinity DataIC50: 6.10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50177285(CHEMBL204428 | rac-N-(2-(3-(dimethylamino)pyrrolid...)
Show SMILES CN(C)C1CCN(C1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C25H27F3N4O3/c1-16-12-23(32-11-10-18(14-32)31(2)3)30-22-9-4-17(13-21(16)22)29-24(33)15-34-19-5-7-20(8-6-19)35-25(26,27)28/h4-9,12-13,18H,10-11,14-15H2,1-3H3,(H,29,33)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human MCH1 receptor by SPA assayMore data for this Ligand-Target Pair
Displayed 1 to 50 (of 318 total ) | Next | Last >>
Jump to: