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Target5-hydroxytryptamine receptor 1A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208446(CHEMBL3884161)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208470(CHEMBL3885003)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A,L591M](Human immunodeficiency virus type 1)
Georgia State University

LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0300nMAssay Description:The inhibition assays were performed in microtiter plate wells by mixing enzyme and fluorescent peptide substrate in the presence of inhibitor compou...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Human)
Peking University First Hospital

US Patent
LigandPNGBDBM642537(US20230414794, Compound S2)
Affinity DataKi:  0.0800nMAssay Description:This test example is used to display the results of the PSMA inhibitory activity tested for each compound and comparative compound. A LNCaP cell lysa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM194780(7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butox...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H](+)8-OH-DPAT from human 5HT1A receptor expressed in human HeLa cells measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
The University of Toledo

Curated by ChEMBL
LigandPNGBDBM50107697(1-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity towards M1 muscarinic receptor expressed in A9 L cells by diaplacing [3H]-(R)-QNB radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16254((2,5-dimethyl-1,3-oxazol-4-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  0.120nM ΔG°:  -58.9kJ/molepH: 4.5 T: 37°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328970(CHEMBL1270066 | N-((3S,6S)-6-(((R)-1-(3,5-bis(trif...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]-ketanserine from serotonin 5-HT2A receptor in rat brain cortex homogenates incubated for 30 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H] ketanserin from 5-HT2A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.190nMAssay Description:Binding affinity to 5-HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328981((3R,6S)-6-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]ketanserin from rat cerebral cortex 5HT2A receptor measured after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
The University of Toledo

Curated by ChEMBL
LigandPNGBDBM50107698(1,8-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)...)
Affinity DataKi:  0.190nMAssay Description:Binding affinity towards M1 muscarinic receptor expressed in A9 L cells by diaplacing [3H]-(R)-QNB radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Guinea pig)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50001043(6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membrane incubated for 2.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208451(CHEMBL3885471)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in Sprague-Dawley rat striatum incubated for 30 mins by liquid scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50581486(CHEMBL5082165)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Georgia State University

LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.220nM ΔG°:  -57.3kJ/molepH: 5.6 T: 37°CAssay Description:The inhibition assays were performed in microtiter plate wells by mixing enzyme and fluorescent peptide substrate in the presence of inhibitor compou...More data for this Ligand-Target Pair
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328980((3S,6S)-6-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328973(CHEMBL1270175 | N-((3S,6S)-6-(((R)-1-(3,5-bis(trif...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
The University of Toledo

Curated by ChEMBL
LigandPNGBDBM50107712(1,10-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity towards M1 muscarinic receptor expressed in A9 L cells by diaplacing [3H]-(R)-QNB radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328974(1-((3S,6S)-6-(((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328982((3S,6S)-6-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328979(CHEMBL1270465 | N-((3S,6S)-6-(((R)-1-(3,5-bis(trif...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328972(CHEMBL1270174 | N-((3S,6S)-6-(((R)-1-(3,5-bis(trif...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16253((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  0.300nM ΔG°:  -56.5kJ/molepH: 4.5 T: 37°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

Target5-hydroxytryptamine receptor 2A(Human)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50434823(CHEMBL2387229)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to 5-HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208447(CHEMBL3883955)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H] ketanserin from 5-HT2A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208447(CHEMBL3883955)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to 5-HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM194780(7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butox...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]raclopride from human D2 long receptor expressed in CHO cells measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328988((S)-2-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)etho...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418481(CHEMBL1783282)
Affinity DataKi:  0.309nMAssay Description:Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
The University of Toledo

Curated by ChEMBL
LigandPNGBDBM50107702(1,10-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity towards M1 muscarinic receptor expressed in A9 L cells by diaplacing [3H]-(R)-QNB radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328978(CHEMBL1270464 | N-((3S,6S)-6-(((R)-1-(3,5-bis(trif...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328986((3S,6S)-6-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328971(CHEMBL1270067 | N-((3R,6S)-6-(((R)-1-(3,5-bis(trif...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328984((3S,6S)-6-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418483(CHEMBL1783284)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  0.390nMAssay Description:Inhibition of sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208441(CHEMBL3885254)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in Sprague-Dawley rat striatum incubated for 30 mins by liquid scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50469526(CHEMBL4290311)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-ketanserine from serotonin 5-HT2A receptor in rat brain cortex homogenates incubated for 30 mins by liquid scintillation countin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208441(CHEMBL3885254)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H] ketanserin from 5-HT2A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328987((3R,6S)-6-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418482(CHEMBL1783283)
Affinity DataKi:  0.407nMAssay Description:Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM194780(7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butox...)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO-K1 cells measured after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Human)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208447(CHEMBL3883955)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208442(CHEMBL3884733)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H] ketanserin from 5-HT2A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Human)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208447(CHEMBL3883955)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5-HT6 receptor expressed in CHO cell membranes for 30 mins by liquid scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208451(CHEMBL3885471)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H] ketanserin from 5-HT2A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Huazhong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208447(CHEMBL3883955)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in Sprague-Dawley rat striatum incubated for 30 mins by liquid scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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