Report error Found 4753 with Last Name = 'lopez' and Initial = 'p'
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council
Curated by ChEMBL
National Research Council
Curated by ChEMBL
Affinity DataEC50: 2.08E+4nMAssay Description:Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-bas...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council
Curated by ChEMBL
National Research Council
Curated by ChEMBL
Affinity DataEC50: 1.42E+4nMAssay Description:Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-bas...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council
Curated by ChEMBL
National Research Council
Curated by ChEMBL
Affinity DataEC50: 1.59E+4nMAssay Description:Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-bas...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council
Curated by ChEMBL
National Research Council
Curated by ChEMBL
Affinity DataEC50: 2.61E+4nMAssay Description:Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-bas...More data for this Ligand-Target Pair
Affinity DataKd: 1.08E+4nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 7.20E+3nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.26E+4nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.06E+4nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.09E+5nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.88E+4nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 5.40E+5nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.66E+5nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.66E+5nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 9.00E+5nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKd: 2.96E+5nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 6.10E+3nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.00E+6nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.42E+4nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.84E+4nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.20E+3nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant BACE1 pre-incubated with enzyme for 60 mins before fluorescent substrate addition FRET methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.440nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.480nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
