Compile Data Set for Download or QSAR
Found 262 with Last Name = 'lubisch' and Initial = 'w'
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345133((S)-1-((R)-5-chloro-3-(2-methoxy-5-(pyrrolidin-1-y...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345134((S)-1-((R)-5-chloro-3-(2-methoxy-5-((4-methylpiper...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345131((S)-1-((R)-5-chloro-3-(2-methoxy-4-((4-methylpiper...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345130((S)-1-((R)-5-chloro-3-(2-methoxy-4-(pyrrolidin-1-y...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345132((S)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulfonyl...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176440(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345129((S)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulfonyl...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345139((R)-5-chloro-3-(2-methoxy-5-(pyrrolidin-1-ylmethyl...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345143((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345142((R)-5-chloro-3-(2-methoxy-5-((4-methylpiperazin-1-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345140((R)-5-chloro-3-(5-((dimethylamino)methyl)-2-methox...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345145((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176451(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27122(2-[1-(4-cyanophenyl)piperidin-4-yl]-1H-1,3-benzodi...)
Affinity DataKi:  3nMAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176446(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50116042(CHEMBL63861 | {7-[3-(4-Benzyl-piperazin-1-ylmethyl...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards cloned human GluR5 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345144((S)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulfonyl...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176445(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345141((R)-5-chloro-3-(2-methoxy-5-((methylamino)methyl)p...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27096(2-(pyrrolidin-3-yl)-1H-1,3-benzodiazole-4-carboxam...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27124(2-(1-cyclopentylazepan-4-yl)-1H-1,3-benzodiazole-4...)
Affinity DataKi:  4nMAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176452(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27101(2-(azepan-4-yl)-1H-1,3-benzodiazole-4-carboxamide ...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27100(2-(piperidin-4-yl)-1H-1,3-benzodiazole-4-carboxami...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27123(2-[1-(propan-2-yl)azepan-4-yl]-1H-1,3-benzodiazole...)
Affinity DataKi:  5nMAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27112(2-(1-cyclopentylpyrrolidin-3-yl)-1H-1,3-benzodiazo...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345147((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27093(2-(azetidin-3-yl)-1H-1,3-benzodiazole-4-carboxamid...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50112833(CHEMBL280587 | N-(1-Benzyl-2-carbamoyl-2-oxo-ethyl...)
Affinity DataKi:  6nMAssay Description:Inhibition of calpain, using human mu-calpain isolated from erythrocytes and Suc-Leu-Tyr-AMC as the fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27121(2-(1-cyclopentylpiperidin-4-yl)-1H-1,3-benzodiazol...)
Affinity DataKi:  6nMAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345131((S)-1-((R)-5-chloro-3-(2-methoxy-4-((4-methylpiper...)
Affinity DataKi:  7nMAssay Description:Displacement of radiolebelled oxytocin from human oxytocin receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27120(2-[1-(propan-2-yl)piperidin-4-yl]-1H-1,3-benzodiaz...)
Affinity DataKi:  7nMAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27094(2-[(2R)-pyrrolidin-2-yl]-1H-1,3-benzodiazole-4-car...)
Affinity DataKi:  7nM ΔG°:  -46.1kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27106(2-[(2R)-1-methylpyrrolidin-2-yl]-1H-1,3-benzodiazo...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27110(2-(1-propylpyrrolidin-3-yl)-1H-1,3-benzodiazole-4-...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27119(2-(1-propylpiperidin-4-yl)-1H-1,3-benzodiazole-4-c...)
Affinity DataKi:  8nMAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50128678(CHEMBL310855 | N-(1-Carbamoyl-2-phenyl-ethyl)-2-(2...)
Affinity DataKi:  8.40nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27111(2-[1-(propan-2-yl)pyrrolidin-3-yl]-1H-1,3-benzodia...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27113(2-[1-(2-phenylethyl)pyrrolidin-3-yl]-1H-1,3-benzod...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50092301(1-(Benzo[b]thiophene-2-carbonyl)-piperidine-4-carb...)
Affinity DataKi:  9nMAssay Description:Inhibition of Suc-Leu-Tyr-AMC binding to human mu-calpain from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176447(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  9.20nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176454(5-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345133((S)-1-((R)-5-chloro-3-(2-methoxy-5-(pyrrolidin-1-y...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176450(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  10.1nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27099(2-(piperidin-3-yl)-1H-1,3-benzodiazole-4-carboxami...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 8.0 T: 2°CAssay Description:PARP assays utilizing SPA bead-based detection were carried out in 96-well plates. After reaction was terminated, the reaction mixtures were transfer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176441(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  11.2nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50116048(CHEMBL67828 | {6-Nitro-2,3-dioxo-7-[3-(4-phenethyl...)
Affinity DataKi:  12nMAssay Description:Binding affinity towards cloned human GluR5 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176448(4-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  12.1nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345134((S)-1-((R)-5-chloro-3-(2-methoxy-5-((4-methylpiper...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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