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TargetG-protein coupled bile acid receptor 1(Human)
University Di Perugia

LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  6.71E+3nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
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PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University Di Perugia

LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  755nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University Di Perugia

LigandPNGBDBM21676((2S,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50:  3.58E+3nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University Di Perugia

LigandPNGBDBM21677((2R,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50:  2.55E+4nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University Di Perugia

LigandPNGBDBM21678((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-5,9...)
Affinity DataEC50:  140nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University Di Perugia

LigandPNGBDBM21679((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-e...)
Affinity DataEC50:  95nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University Di Perugia

LigandPNGBDBM21680(Cholic Acid | (R)-4-((3R,5S,7R,8R,10S,12S,13R,14S,...)
Affinity DataEC50:  1.36E+4nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University Di Perugia

LigandPNGBDBM21681(23(S)-Methyl-3alpha,7alpha, 12alpha-trihydroxy-5be...)
Affinity DataEC50:  4.39E+3nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University Di Perugia

LigandPNGBDBM21682((2R,4R)-2-methyl-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15...)
Affinity DataEC50: >5.19E+4nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  1.30E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  361nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM21676((2S,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50: >1.00E+5nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM21677((2R,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50:  1.05E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM21678((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-5,9...)
Affinity DataEC50:  1.16E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM21679((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-e...)
Affinity DataEC50:  1.18E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278531(CHEMBL4166195)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278825(CHEMBL4164173)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278854(CHEMBL1548961)
Affinity DataKd:  5.37E+4nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278855(CHEMBL4168345)
Affinity DataKd:  1.78E+4nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278856(CHEMBL4169427)
Affinity DataKd:  3.35E+4nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278857(CHEMBL4167622)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278862(CHEMBL273361)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50126144(CHEMBL3629569 | US10155972, Compound NewLink 1 | U...)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278864(CHEMBL1444619)
Affinity DataKd:  9.41E+5nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278870(CHEMBL1868762)
Affinity DataKd:  7.74E+5nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278871(CHEMBL4176811)
Affinity DataKd:  8.68E+4nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278874(CHEMBL4161086)
Affinity DataKd:  1.69E+5nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278875(CHEMBL4171690)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278876(CHEMBL4172821)
Affinity DataKd:  9.70E+4nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278952(CHEMBL4173241)
Affinity DataKd:  9.67E+4nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278953(CHEMBL4159709)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278960(CHEMBL4174827)
Affinity DataKd:  2.40E+5nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278961(CHEMBL4171383)
Affinity DataKd:  6.15E+4nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278962(CHEMBL4176201)
Affinity DataKd:  5.48E+5nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278963(CHEMBL4162557)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278964(CHEMBL1345047)
Affinity DataKd:  1.47E+5nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278965(CHEMBL3988796)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50278966(CHEMBL4160780)
Affinity DataKd:  2.37E+5nMAssay Description:Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM50290176(CHEMBL4160181)
Affinity DataEC50:  7.60E+4nMAssay Description:Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM50375599(Deoxycholic Acid | DEOXYCHOLATE | KYBELLA)
Affinity DataEC50:  4.50E+4nMAssay Description:Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM50290255(CHEMBL4168102)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM50236238(5beta-cholanic acid-3alpha-ol | CHEMBL1478 | (3alp...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM50290256(CHEMBL4170402)
Affinity DataEC50:  9.15E+4nMAssay Description:Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM21680(Cholic Acid | (R)-4-((3R,5S,7R,8R,10S,12S,13R,14S,...)
Affinity DataEC50:  4.50E+4nMAssay Description:Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM50290257(CHEMBL4159764)
Affinity DataEC50:  8.00E+3nMAssay Description:Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotin-labeled SRC-1 recruitment after 30 mins by Alpha Screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM50290257(CHEMBL4159764)
Affinity DataEC50:  1.10E+4nMAssay Description:Transactivation of full length FXR (unknown origin) expressed in HEK293 cells co-expressing pSG5RXR/pGL4.74/ pGL4.23(IR1)X3 after 18 hrs by luciferas...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
University Di Perugia

LigandPNGBDBM50290255(CHEMBL4168102)
Affinity DataEC50:  3.50E+4nMAssay Description:Transactivation of full length FXR (unknown origin) expressed in HEK293 cells co-expressing pSG5RXR/pGL4.74/ pGL4.23(IR1)X3 after 18 hrs by luciferas...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetAryl hydrocarbon receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50506038(CHEMBL4580482)
Affinity DataEC50:  49nMAssay Description:Binding affinity to AhR (unknown origin) relative to TCDDMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAryl hydrocarbon receptor(Mouse)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50506039(CHEMBL1324296 | US11891386, Compound 002)
Affinity DataKd:  3nMAssay Description:Displacement of [3H]TCDD from mouse AhRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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