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TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50409486(CHEMBL2111533)
Affinity DataEC50:  2.80E+3nMAssay Description:Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50085818(N6-Methyl-1,5-anhydro-2-(adenin-9-yl)-2,3-dideoxy-...)
Affinity DataEC50:  9.35E+3nMAssay Description:In vitro stimulation of 2PY1 purinoceptor mediated phospholipase C (PLC) activity in Turkey Erythrocyte GhostsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011799(CHEMBL3262934)
Affinity DataKd:  560nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011800(CHEMBL3262935)
Affinity DataKd:  865nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 6(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50403871(URIDINE_DIPHOSPHATE)
Affinity DataEC50:  15nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 6 (hP2Y6) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50100417((1R,2S,4S,5S)-4-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataEC50:  2.28E+3nMAssay Description:Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, at human Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50088428((1R,2R,3S,4R,5S)-4-[2-Chloro-6-(3-iodo-benzylamino...)
Affinity DataEC50:  0.670nMAssay Description:Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50409486(CHEMBL2111533)
Affinity DataEC50:  91nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM18137(adenosine 5 -monophosphate | CHEMBL752 | [(2R,3S,4...)
Affinity DataEC50:  3.70E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011802(CHEMBL3262937)
Affinity DataKd:  1.07E+3nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50076474(Phosphoric acid mono-[5-(6-amino-purin-9-yl)-2-pho...)
Affinity DataEC50:  2.99E+3nMAssay Description:In vitro stimulation of 2PY1 purinoceptor mediated phospholipase C (PLC) activity in Turkey Erythrocyte GhostsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011807(CHEMBL3262942)
Affinity DataKd:  0.600nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  155nMAssay Description:Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50088425(1-hydroxymethyl-4-[6-(3-iodobenzylamino)-9H-9-puri...)
Affinity DataEC50:  940nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM18137(adenosine 5 -monophosphate | CHEMBL752 | [(2R,3S,4...)
Affinity DataEC50:  3.50E+3nMAssay Description:Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.230nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlcohol dehydrogenase E/S chain(Horse)
University of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50421763(CHEMBL2364562)
Affinity DataKd:  2.70E+4nMAssay Description:Dissociation constant from Alcohol dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50088423((1R,2R,3S,4R,5S)-4-(2-Chloro-6-cyclopentylamino-pu...)
Affinity DataEC50: >1.00E+4nMAssay Description:Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene vav(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to VAV1 C1 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011798(CHEMBL3262933)
Affinity DataKd:  2.10E+3nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM18137(adenosine 5 -monophosphate | CHEMBL752 | [(2R,3S,4...)
Affinity DataEC50:  7.20E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50085822(Phosphoric acid mono-[1-(6-amino-purin-9-yl)-4-pho...)
Affinity DataEC50:  1.89E+4nMAssay Description:In vitro stimulation of 2PY1 purinoceptor mediated phospholipase C (PLC) activity in Turkey Erythrocyte GhostsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50088420(3-Hydroxymethyl-5-[6-(3-iodo-benzylamino)-purin-9-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50100416(1N-methyl-4-(2-amino-6-methylamino-9H-9-purinyl)-2...)
Affinity DataEC50:  2.55E+4nMAssay Description:Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50085313(Phosphoric acid mono-[4-(6-amino-purin-9-ylmethyl)...)
Affinity DataEC50:  7.21E+3nMAssay Description:In vitro stimulation of 2PY1 purinoceptor mediated phospholipase C (PLC) activity in Turkey Erythrocyte GhostsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM18137(adenosine 5 -monophosphate | CHEMBL752 | [(2R,3S,4...)
Affinity DataEC50:  7.20E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50085825(Phosphoric acid mono-[4-(6-amino-purin-9-yl)-1-pho...)
Affinity DataEC50:  155nMAssay Description:In vitro stimulation of 2PY1 purinoceptor mediated phospholipase C (PLC) activity in Turkey Erythrocyte GhostsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50306712(((1R,2R,3S,4R,5S)-4-(2,4-dioxo-3,4-dihydropyrimidi...)
Affinity DataEC50:  85nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 4 (hP2Y4) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011808(CHEMBL3262943)
Affinity DataKd:  777nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50088423((1R,2R,3S,4R,5S)-4-(2-Chloro-6-cyclopentylamino-pu...)
Affinity DataEC50:  31nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011801(CHEMBL3262936)
Affinity DataKd:  1.21E+3nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50085829(Phosphoric acid mono-[4-(2-amino-6-methylamino-pur...)
Affinity DataEC50:  6.51E+3nMAssay Description:In vitro stimulation of 2PY1 purinoceptor mediated phospholipase C (PLC) activity in Turkey Erythrocyte GhostsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataEC50:  4.20nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataEC50:  20nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to adenosine A1 receptor of rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50409486(CHEMBL2111533)
Affinity DataEC50:  85nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50187544((E)-{2-(hydroxymethyl)-4-[(2-hydroxyphenyl)methyle...)
Affinity DataKd:  3nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM92594(Phorbol ester (PDBU))
Affinity DataKd:  10.3nMpH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50088422((2R,3R,4S,5R)-2-(6-(3-iodobenzylamino)-9H-purin-9-...)
Affinity DataEC50:  43nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 6(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50179185(DEOXYURIDINE-5'-DIPHOSPHATE | 2'-Deoxyuridine-5'-d...)
Affinity DataEC50:  1.72E+3nMAssay Description:Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50409486(CHEMBL2111533)
Affinity DataEC50:  1.50E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 11(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50409486(CHEMBL2111533)
Affinity DataEC50:  1.73E+4nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 2(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50306712(((1R,2R,3S,4R,5S)-4-(2,4-dioxo-3,4-dihydropyrimidi...)
Affinity DataEC50:  15.9nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM92594(Phorbol ester (PDBU))
Affinity DataKd:  3.40nMpH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.800nMAssay Description:Dissociation constant for Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50011806(CHEMBL3262941)
Affinity DataKd:  0.5nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50088424(4-(6-Cyclopentylamino-purin-9-yl)-1-hydroxymethyl-...)
Affinity DataEC50:  22nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50187521((E)-{2-(hydroxymethyl)-4-[(4-hydroxyphenyl)methyle...)
Affinity DataKd:  3nMAssay Description:Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Mouse)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  383nMAssay Description:Binding affinity to mouse PKC delta C1a Q27E mutant expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50088424(4-(6-Cyclopentylamino-purin-9-yl)-1-hydroxymethyl-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM18137(adenosine 5 -monophosphate | CHEMBL752 | [(2R,3S,4...)
Affinity DataEC50:  3.50E+3nMAssay Description:Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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