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TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14073((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)
Affinity DataKi:  0.000650nM ΔG°:  -72.4kJ/mole IC50:  4.5nMpH: 7.4 T: 37°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14073((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)
Affinity DataKi:  0.000650nMAssay Description:Inhibition of human alpha-thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14073((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)
Affinity DataKi:  0.000650nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14065((2S)-1-[(2R)-2-amino-3-phenylpropanoyl]-N-[1-(1,3-...)
Affinity DataKi:  0.00550nM ΔG°:  -66.9kJ/mole IC50:  21nMpH: 7.4 T: 37°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14127(2-(5-carbamimidamido-2-{[(2S)-1-[(2R)-2-(methylami...)
Affinity DataKi:  0.00700nM IC50:  5nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50328697((R)-5-guanidino-N-(2-((S)-5-guanidino-1-oxo-1-(thi...)
Affinity DataKi:  0.0140nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14076((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)
Affinity DataKi:  0.0180nM ΔG°:  -63.8kJ/mole IC50:  5.30nMpH: 7.4 T: 37°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50139746((S)-1-((R)-3-Cyclohexyl-2-methylamino-propionyl)-p...)
Affinity DataKi:  0.0180nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50320472((3S,6S,9S,15S)-3-((4R,7S,10S,13S,16S,19R)-13-((1H-...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [125I]U2 from rat urotensin 2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50095523(CHEMBL285231 | [(S)-2-methyl-1-((S)-2-{(S)-2-methy...)
Affinity DataKi:  0.0250nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50374350(CHEMBL403098)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029246(1-[5-(4-Benzofuran-7-yl-piperazin-1-ylmethyl)-thio...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50076232((1S,7S)-7-Amino-7-benzyl-8-oxo-hexahydro-pyrazolo[...)
Affinity DataKi:  0.0710nMAssay Description:Inhibition of human alpha-thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50069019(7-Chloro-1-(4-fluoro-phenyl)-8,9-dimethoxy-4-methy...)
Affinity DataKi:  0.0900nMAssay Description:Affinity for 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50161518(1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one...)
Affinity DataKi:  0.0940nMAssay Description:Inhibition of human recombinant FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50123504(CHEMBL142546 | N-((6-amino-2-methylpyridin-3-yl)me...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50031203(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14066((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)
Affinity DataKi:  0.120nM ΔG°:  -58.9kJ/mole IC50:  15nMpH: 7.4 T: 37°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50302273((4R,7S,10S,13S,16S,19R)-13-((1H-indol-3-yl)methyl)...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [125I]U2 from rat urotensin 2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50302273((4R,7S,10S,13S,16S,19R)-13-((1H-indol-3-yl)methyl)...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [125I]urotensin 2 from rat urotensin 2 receptor expressed in CHOK1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029326(8-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...)
Affinity DataKi:  0.130nMAssay Description:Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14123((2S)-N-[5-carbamimidamido-1-(6-methoxy-1,3-benzoth...)
Affinity DataKi:  0.140nM IC50:  5nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50374357(CHEMBL404043)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human alpha-thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM82247(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity towards Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14125((2S)-N-[5-carbamimidamido-1-(6-fluoro-1,3-benzothi...)
Affinity DataKi:  0.150nM IC50:  7.5nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50374356(CHEMBL404042)
Affinity DataKi:  0.150nMAssay Description:Inhibition of human alpha-thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50028288(6-(4-Chloro-phenyl)-1,2,3,5,6,10b-hexahydro-pyrrol...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50367554(CHEMBL1743782)
Affinity DataKi:  0.160nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14068((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)
Affinity DataKi:  0.180nM ΔG°:  -57.9kJ/mole IC50:  48nMpH: 7.4 T: 37°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50320454(AGTAD[CFWKYC]V | CHEMBL1163463)
Affinity DataKi:  0.190nMAssay Description:Displacement of [125I]U2 from rat urotensin 2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50228853((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human alpha-thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14071((2S)-1-(2-amino-2-benzylpropanoyl)-N-[1-(1,3-benzo...)
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/mole IC50:  3.5nMpH: 7.4 T: 37°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14063((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/mole IC50:  29nMpH: 7.4 T: 37°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50031198(1-(4-(((S)-1-((S)-2-(((S)-1-(benzo[d]oxazol-2-yl)-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity was determined against Dopamine receptor D2 using [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50228853((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human alpha-thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50374345(CHEMBL256253)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human alpha-thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50374347(CHEMBL270680)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50161518(1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of rat FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50228837(2-(3-(biphenyl-4-yl)propanoyl)oxazole-5-carbonitri...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of rat FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.200nMAssay Description:Affinity for 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50452190(CHEMBL2093944)
Affinity DataKi:  0.200nMAssay Description:Inhibition of norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.200nMAssay Description:Affinity for Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50228853((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50367584(CHEMBL1743810)
Affinity DataKi:  0.200nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50064563(CHEMBL61816 | [3-(4-Benzofuran-6-yl-piperazin-1-yl...)
Affinity DataKi:  0.210nMAssay Description:Compound was evaluated for its binding affinity against 5-hydroxytryptamine 1A receptor from rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14124((2S)-N-[5-carbamimidamido-1-(6-hydroxy-1,3-benzoth...)
Affinity DataKi:  0.230nM IC50:  3nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50029262(Pentanoic acid {5-[4-(2-isopropoxy-phenyl)-piperaz...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50228837(2-(3-(biphenyl-4-yl)propanoyl)oxazole-5-carbonitri...)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human recombinant FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50161512(7-Phenyl-1-(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)...)
Affinity DataKi:  0.290nMAssay Description:Inhibition of rat FAAHMore data for this Ligand-Target Pair
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