Compile Data Set for Download or QSAR
Found 1151 with Last Name = 'matthews' and Initial = 'd'
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50046660(2-[4-(2-Amino-6-methyl-4-oxo-3,4-dihydro-quinazoli...)
Affinity DataKi:  0.124nMAssay Description:Compound was tested for TS activity against human Thymidylate synthase by tight binding kineticsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50367916(METHYLTRIENOLONE | Metribolone | R-1881)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-methyltrienolone from androgen receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta scinti...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50367916(METHYLTRIENOLONE | Metribolone | R-1881)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]-methyltrienolone from progesterone receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta sc...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50367916(METHYLTRIENOLONE | Metribolone | R-1881)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]-aldosterone from mineralocorticoid receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50145862(CHEMBL3765171)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]-methyltrienolone from androgen receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Dog)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50026636(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
In DepthDetails PubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50046665(2-[4-(2,6-Dimethyl-4-oxo-3,4-dihydro-quinazolin-5-...)
Affinity DataKi:  1.31nMAssay Description:Compound was tested for TS activity against human Thymidylate synthase by tight binding kineticsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50145863(CHEMBL3764185)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-methyltrienolone from androgen receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta scinti...More data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Dog)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
In DepthDetails PubMed
TargetAlpha-2C adrenergic receptor(RAT)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50019848(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
In DepthDetails PubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50055234(1-(6-Methoxy-naphthalen-2-ylmethyl)-2,3-dioxo-2,3-...)
Affinity DataKi:  3nMAssay Description:Inhibition of human rhinovirus 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(GUINEA PIG)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50019848(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
In DepthDetails PubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50055213(1-(3,5-Dihydroxy-benzyl)-2,3-dioxo-2,3-dihydro-1H-...)
Affinity DataKi:  4nMAssay Description:Inhibition of human rhinovirus 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50055232(1-(6-Hydroxy-naphthalen-2-ylmethyl)-2,3-dioxo-2,3-...)
Affinity DataKi:  4nMAssay Description:Inhibition of human rhinovirus 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataKi:  4nMAssay Description:Inhibition of human rhinovirus 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50065598(CHEMBL419332 | {(S)-1-[(S)-1-((S)-3-Dimethylcarbam...)
Affinity DataKi:  5nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataKi:  5nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-2A adrenergic receptor(GUINEA PIG)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50026636(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
In DepthDetails PubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50005335(2-[4-(2-Amino-1,6,7,8-tetrahydro-imidazo[4,5-g]qui...)
Affinity DataKi:  5nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50065588(CHEMBL96803 | [(S)-1-((S)-1-{(S)-1-Formyl-2-[(isox...)
Affinity DataKi:  5nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50065603(CHEMBL96185 | {(S)-1-[(S)-1-((S)-1-Formyl-3-methan...)
Affinity DataKi:  5nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50145860(CHEMBL3764446)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]-methyltrienolone from androgen receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50065590(((S)-1-{(S)-1-[(S)-1-(Acetylamino-methyl)-2-oxo-et...)
Affinity DataKi:  6nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(GUINEA PIG)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
In DepthDetails PubMed
TargetAlpha-2C adrenergic receptor(RAT)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
In DepthDetails PubMed
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Homo sapiens (Human))
Pfizer Inc

LigandPNGBDBM34012(3-fluorophenylalanine derivative, 21b)
Affinity DataKi:  6nM ΔG°:  -45.4kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50055217(1-(3,4-Dimethyl-benzyl)-2,3-dioxo-2,3-dihydro-1H-i...)
Affinity DataKi:  6nMAssay Description:Inhibition of human rhinovirus 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50005329(5-[4-(Morpholine-4-sulfonyl)-benzyl]-5,6,7,8-tetra...)
Affinity DataKi:  6nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50225305(CHEMBL433730)
Affinity DataKi:  6.10nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50065586(((S)-3-Methyl-1-{(S)-1-[(S)-2-oxo-1-(propionylamin...)
Affinity DataKi:  7nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Homo sapiens (Human))
Pfizer Inc

LigandPNGBDBM34011(3-fluorophenylalanine derivative, 21a)
Affinity DataKi:  8nM ΔG°:  -44.7kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(GUINEA PIG)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50026636(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
In DepthDetails PubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50005324(4-[4-(2-Amino-1,6,7,8-tetrahydro-imidazo[4,5-g]qui...)
Affinity DataKi:  8nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50367916(METHYLTRIENOLONE | Metribolone | R-1881)
Affinity DataKi:  9.70nMAssay Description:Displacement of [3H]-dexamethasone from glucocorticoid receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta sci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50055225(1-(4-Methyl-benzyl)-2,3-dioxo-2,3-dihydro-1H-indol...)
Affinity DataKi:  10nMAssay Description:Inhibition of human rhinovirus 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50065595(((S)-1-{(S)-1-[(S)-2-(3,3-Dimethyl-ureido)-1-formy...)
Affinity DataKi:  10nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50005335(2-[4-(2-Amino-1,6,7,8-tetrahydro-imidazo[4,5-g]qui...)
Affinity DataKi:  11nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50055212(1-(3-Hydroxy-benzyl)-2,3-dioxo-2,3-dihydro-1H-indo...)
Affinity DataKi:  11nMAssay Description:Inhibition of human rhinovirus 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50005329(5-[4-(Morpholine-4-sulfonyl)-benzyl]-5,6,7,8-tetra...)
Affinity DataKi:  11nMAssay Description:Inhibition of Escherichia coli Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50046646(2-Amino-6-methyl-5-(pyridazin-4-ylsulfanyl)-3H-qui...)
Affinity DataKi:  11nMAssay Description:Inhibition of human Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50011244(6-{[(4-Benzenesulfonyl-phenyl)-prop-2-ynyl-amino]-...)
Affinity DataKi:  12nMAssay Description:Binding affinity against recombinant human thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50065599(CHEMBL94652 | {(S)-1-[(S)-1-((S)-2-Benzoylamino-1-...)
Affinity DataKi:  12nMAssay Description:Binding affinity against HRV-14 3C protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50011244(6-{[(4-Benzenesulfonyl-phenyl)-prop-2-ynyl-amino]-...)
Affinity DataKi:  12nMAssay Description:Binding affinity against recombinant human thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Mus musculus (Mouse))
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50019848(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2C adrenergic receptor(RAT)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50026636(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2A adrenergic receptor(GUINEA PIG)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM66983(6-chloranyl-3-methyl-1,2,4,5-tetrahydro-3-benzazep...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50005330(5-(4-Benzenesulfonyl-benzyl)-5,6,7,8-tetrahydro-1H...)
Affinity DataKi:  13nMAssay Description:Inhibition of human Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(GUINEA PIG)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50046657(2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quina...)
Affinity DataKi:  15nMAssay Description:Inhibition of human Thymidylate synthaseMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Agouron Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50046657(2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quina...)
Affinity DataKi:  16nMAssay Description:Inhibition of human Thymidylate synthaseMore data for this Ligand-Target Pair
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