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TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 22nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVacuolar proton pump subunit B(Chicken)
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50064186((3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-...)
Affinity DataIC50: 30nMAssay Description:Compound was tested for inhibition of osteoclast vacuolar ATPase derived from chicken medullary boneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetVacuolar proton pump subunit B(Chicken)
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50064182((2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-p...)
Affinity DataIC50: 49nMAssay Description:Compound was tested for inhibition of osteoclast vacuolar ATPase derived from chicken medullary boneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182823(4-(3,4-dichlorophenylthio)-2-(5-fluoropyridin-2-yl...)
Affinity DataIC50: 80nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182811(4-(3,4-dichlorophenylthio)-2-(pyridin-2-yl)pyrimid...)
Affinity DataIC50: 90nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179654(1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 180nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182813(2-(pyridin-2-yl)-4-(4-(trifluoromethyl)phenylthio)...)
Affinity DataIC50: 210nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179654(1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 250nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179643(1-(3-chlorophenyl)-3-(3-methylthiazolidin-2-yliden...)
Affinity DataIC50: 260nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182822(4-(4-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine ...)
Affinity DataIC50: 320nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179642(1-(3-chlorophenyl)-3-(1-ethyl-5-methyl-4-oxoimidaz...)
Affinity DataIC50: 320nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM86716(NSC_216215 | CAS_63540-28-3 | CHEMBL239800 | Fenob...)
Affinity DataIC50: 330nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179667(1-(3-bromophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 380nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182819(4-(3,4-dichlorophenylthio)-2-(6-methylpyridin-2-yl...)
Affinity DataIC50: 390nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179642(1-(3-chlorophenyl)-3-(1-ethyl-5-methyl-4-oxoimidaz...)
Affinity DataIC50: 410nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM86716(NSC_216215 | CAS_63540-28-3 | CHEMBL239800 | Fenob...)
Affinity DataIC50: 460nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179645(1-(3-chlorophenyl)-3-(1,5-dimethyl-4-oxoimidazolid...)
Affinity DataIC50: 490nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182816(2-(pyridin-2-yl)-4-(3-(trifluoromethyl)phenylthio)...)
Affinity DataIC50: 550nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179669(1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-m-tolyl...)
Affinity DataIC50: 550nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179641(1-(3-chlorophenyl)-3-(1-methylpyrrolidin-2-ylidene...)
Affinity DataIC50: 620nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182809(4-(3-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine ...)
Affinity DataIC50: 620nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179646(1-(1-butyl-4-oxoimidazolidin-2-ylidene)-3-(3-chlor...)
Affinity DataIC50: 680nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179640(1-(3-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...)
Affinity DataIC50: 800nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179643(1-(3-chlorophenyl)-3-(3-methylthiazolidin-2-yliden...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182814(4-(4-chlorophenylthio)-6-methyl-2-(pyridin-2-yl)py...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179645(1-(3-chlorophenyl)-3-(1,5-dimethyl-4-oxoimidazolid...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179646(1-(1-butyl-4-oxoimidazolidin-2-ylidene)-3-(3-chlor...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179644(1-(1-methyl-4-oxo-5-phenylimidazolidin-2-ylidene)-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVacuolar proton pump subunit B(Chicken)
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50086850((2E,4E)-Hexa-2,4-dienedioic acid (3,4-dichloro-phe...)
Affinity DataIC50: 1.50E+3nMAssay Description:Compound was tested for inhibition of osteoclast vacuolar ATPase derived from chicken medullary boneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182821(4-(3,4-difluorophenylthio)-2-(pyridin-2-yl)pyrimid...)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179640(1-(3-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...)
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179657((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179641(1-(3-chlorophenyl)-3-(1-methylpyrrolidin-2-ylidene...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179666(3-chloro-N-(1-methyl-4-oxoimidazolidin-2-ylidene)b...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182815(2-(pyridin-2-yl)-4-(m-tolylthio)pyrimidine | CHEMB...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182812(2-(4-(3,4-dichlorophenylthio)pyridin-2-yl)pyridine...)
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179662(1-(3-methoxyphenyl)-3-(1-methyl-4-oxoimidazolidin-...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182817(4-(3-bromophenylthio)-2-(pyridin-2-yl)pyrimidine |...)
Affinity DataIC50: 2.86E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182805((4-chlorophenyl)(2-(pyridin-2-yl)pyrimidin-4-yl)me...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179665(1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(5-meth...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179652(1-(3-cyanophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 3.40E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179652(1-(3-cyanophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179660(1-(1-oxo-hexahydropyrrolo[1,2-e]imidazol-3-ylidene...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179668(1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(thioph...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVacuolar proton pump subunit B(Chicken)
Astrazeneca R & D M£Lndal

Curated by ChEMBL
LigandPNGBDBM50086849(3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-N-(2,2,6...)
Affinity DataIC50: 4.90E+3nMAssay Description:Compound was tested for inhibition of osteoclast vacuolar ATPase derived from chicken medullary boneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201659((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-phe...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50179655(1-(3-chlorophenyl)-3-(1-methyl-1H-imidazol-2-yl)ur...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182810(4-(4-chlorophenylthio)-2-(pyridin-3-yl)pyrimidine ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182806(4-(4-chlorobenzyl)-2-(pyridin-2-yl)pyrimidine | CH...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182818(N-(4-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-ami...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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