Compile Data Set for Download or QSAR
Found 348 with Last Name = 'mcinally' and Initial = 't'
TargetIntegrin alpha-V/beta-6(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50110227(3-{2-[4-(4-Methyl-pyridin-2-ylamino)-butyrylamino]...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by Merck binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344999(2-(2'-chloro-4'-(N-methylmethylsulfonamido)-5-(tri...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344993(2-(2'-chloro-4'-(methylsulfonyl)-5-(trifluoromethy...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344996(2-(5'-cyano-2'-fluoro-5-(trifluoromethyl)biphenyl-...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344995(2-(5'-cyano-2'-methyl-5-(trifluoromethyl)biphenyl-...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344992(2-(2'-chloro-4'-(ethylsulfonyl)-5-(trifluoromethyl...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50026419(CHEMBL1778628)
Affinity DataIC50: <0.400nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344998(2-(2'-methyl-4'-(N-methylmethylsulfonamido)-5-(tri...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344974((R)-2-(3'-cyano-5-(trifluoromethyl)biphenyl-2-ylox...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344975((2R)-2-(2'-chloro-4'-(ethylsulfonyl)-5-(trifluorom...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344988(2-(2',5-dichloro-4'-(methylsulfonyl)biphenyl-2-ylo...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50345003(2-(4'-(N-methylmethylsulfonamido)-5-(trifluorometh...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Mus musculus (mouse))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to mouse CRTh2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50135425(4-{2-(Isoquinoline-5-sulfonylamino)-3-[4-(isoquino...)
Affinity DataIC50:  1nMAssay Description:Antagonistic activity against P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50464126(CHEMBL3356154)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin) by Monsanto binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Rattus norvegicus)
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity to rat CRTh2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50345007(2-(4'-(N,N-diethylsulfamoyl)-5-(trifluoromethyl)bi...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344984(2-(2',5-dichloro-4'-(ethylsulfonyl)biphenyl-2-ylox...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344982((2R)-2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluorom...)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344994(2-(5-chloro-3'-cyanobiphenyl-2-yloxy)acetic acid |...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50345001((5-Trifluoromethyl-[1,1':2',1'']terphenyl-2-yloxy)...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124519(5,8-Difluoro-2-furan-2-yl-1,2-dihydro-quinazolin-4...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of compound against human inducible nitiric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344997(2-(2'-chloro-5-fluoro-4'-(N-methylmethylsulfonamid...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344978(3-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344985(2-(5-chloro-4'-(ethylsulfonyl)-2'-methylbiphenyl-2...)
Affinity DataIC50:  4.10nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344986(2-(5-chloro-4'-(ethylsulfonyl)-2'-fluorobiphenyl-2...)
Affinity DataIC50:  7.90nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50345008(2-(4'-(ethylthio)-5-(trifluoromethyl)biphenyl-2-yl...)
Affinity DataIC50:  8.90nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344994(2-(5-chloro-3'-cyanobiphenyl-2-yloxy)acetic acid |...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human CRTh2 receptor expressed in CHO cells assessed as inhibition of PGD2-induced calcium flux in presence of 1% bovine serum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50345000(2-(2'-butoxy-5-(trifluoromethyl)biphenyl-2-yloxy)a...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497634(CHEMBL3356184)
Affinity DataIC50:  13nMAssay Description:Inhibition of integrin alphavbeta5 (unknown origin)-mediated K562 cell adhesion to vitronectin coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497612(CHEMBL3356160)
Affinity DataIC50:  16nMAssay Description:Inhibition of integrin alphavbeta5 (unknown origin)-mediated K562 cell adhesion to vitronectin coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497634(CHEMBL3356184)
Affinity DataIC50:  16nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin)-mediated K562 cell adhesion to LAPb1 coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344989(2-(5-chloro-4'-(ethylsulfonyl)biphenyl-2-yloxy)ace...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124537(2-Cyclobutyl-5-fluoro-1,2-dihydro-quinazolin-4-yla...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity of compound against human inducible nitiric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497618(CHEMBL3356158)
Affinity DataIC50:  20nMAssay Description:Inhibition of integrin alphavbeta5 (unknown origin)-mediated K562 cell adhesion to vitronectin coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497612(CHEMBL3356160)
Affinity DataIC50:  23nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin) by Merck binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497608(CHEMBL3356161)
Affinity DataIC50:  25nMAssay Description:Inhibition of integrin alphavbeta5 (unknown origin)-mediated K562 cell adhesion to vitronectin coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50464126(CHEMBL3356154)
Affinity DataIC50:  25nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin)-mediated K562 cell adhesion to LAPb1 coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497606(CHEMBL3356166)
Affinity DataIC50:  25nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin)-mediated K562 cell adhesion to LAPb1 coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124531(4-[4'-amino-5'-fluorospiro[hexahydropyridine-4,2'-...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity of compound against human inducible nitiric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50221044(CHEMBL309253)
Affinity DataIC50: <28nMAssay Description:Inhibition of binding of [125I]IL8 to human recombinant CXC chemokine receptor 2 (CXCR2) expressed in HEK 293 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at human CRTh2 receptor expressed in CHO cells assessed as inhibition of PGD2-induced calcium flux in presence of 1% bovine serum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497612(CHEMBL3356160)
Affinity DataIC50:  32nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin)-mediated K562 cell adhesion to LAPb1 coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124521(CHEMBL174290 | ethyl 4'-amino-5'-fluorospiro[hexah...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity of compound against human inducible nitiric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50345009(2-(4'-(methylsulfonyl)-5-(trifluoromethyl)biphenyl...)
Affinity DataIC50:  36nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  37nMAssay Description:Inhibitory activity of compound against human inducible nitiric oxide synthaseMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124533(2-methylsulfanylethyl 4'-amino-5'-fluorospiro[hexa...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity of compound against human inducible nitiric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497636(CHEMBL3356173)
Affinity DataIC50:  40nMAssay Description:Inhibition of integrin alphavbeta5 (unknown origin)-mediated K562 cell adhesion to vitronectin coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50497624(CHEMBL3356165)
Affinity DataIC50:  40nMAssay Description:Inhibition of integrin alphavbeta3 (unknown origin)-mediated K562 cell adhesion to LAPb1 coated surface by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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