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TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataKi:  0.200nMAssay Description:Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401335(CHEMBL2205798)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401336(CHEMBL2205245)
Affinity DataIC50: 1nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20800(CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethyl...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401334(CHEMBL2205799)
Affinity DataIC50: 2nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataIC50: 3nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401332(CHEMBL2205800)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20800(CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethyl...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401337(CHEMBL2205244)
Affinity DataIC50: 6nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataEC50:  7nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401334(CHEMBL2205799)
Affinity DataEC50:  9nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50161155(CHEMBL3793229)
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataEC50:  14nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401335(CHEMBL2205798)
Affinity DataEC50:  15nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataEC50:  19nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401336(CHEMBL2205245)
Affinity DataEC50:  26nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401332(CHEMBL2205800)
Affinity DataEC50:  32nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50492323(CHEMBL2402205)
Affinity DataIC50: 33nMAssay Description:Displacement of MR121-Nrf2 from human N-terminal His-tagged Kelch-DC domain of Keap1 (321 to 609) expressed in Escherichia coli BL21 (DE3) after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20800(CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethyl...)
Affinity DataEC50:  38nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50161156(CHEMBL3793914)
Affinity DataIC50: 56nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmin(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataKi:  61nMAssay Description:Binding affinity at Grp94 incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50161145(CHEMBL3793667)
Affinity DataIC50: 72nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50161154(CHEMBL3793036)
Affinity DataIC50: 72nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401338(CHEMBL2205243)
Affinity DataEC50:  98nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165669(2-(2-(4-(3-(3-bromophenylamino)-3-oxoprop-1-enyl)-...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147513(2-[3-[5-(4-Chloro-phenyl)-benzooxazol-2-yl]-4-(2-m...)
Affinity DataIC50: 200nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50161157(CHEMBL3792836)
Affinity DataIC50: 200nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165653(2-(2-(4-(3-(3,4-dichlorophenylamino)-3-oxoprop-1-e...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50108881(CHEMBL3596591)
Affinity DataEC50:  200nMAssay Description:Inverse agonist activity at human ROR-gamma transfected in HEK293T cells by Gal4 luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147546(2-[3-(5-Benzo[1,3]dioxol-5-yl-benzooxazol-2-yl)-4-...)
Affinity DataIC50: 200nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165660(2-(3-(5-(4-chlorophenyl)benzo[d]oxazol-2-yl)-4-(pr...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165639(2-(2-(4-(3-(2,4-dichlorophenylamino)-3-oxoprop-1-e...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | [3H]T0901317 | T 0901317 | N-[4-(1,1...)
Affinity DataIC50: 204nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50161110(CHEMBL3792639)
Affinity DataIC50: 210nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50108881(CHEMBL3596591)
Affinity DataIC50: 220nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147534(1,3-dioxo-2-(3-(5-phenylbenzo[d]oxazol-2-yl)-4-(pr...)
Affinity DataIC50: 250nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401337(CHEMBL2205244)
Affinity DataEC50:  250nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein 75 kDa, mitochondrial(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataKi:  255nMAssay Description:Binding affinity at TRAP1 incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165627(2-(2-(4-(3-(3-fluoro-4-methoxyphenylamino)-3-oxopr...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165640(2-(4-(5-(2-chloro-4-(3-(2,4-dichlorophenyl)acrylam...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165614((2-{4-[3-((E)-3-Chloro-2-fluoro-phenyl)-acryloylam...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165638(2-(2-(4-(3-(4-cyanophenylamino)-3-oxoprop-1-enyl)-...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165621((2-{2-Chloro-4-[3-((E)-2,4-dichloro-phenyl)-acrylo...)
Affinity DataIC50: 350nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165624((2-{4-[3-((E)-2,4-Dichloro-phenyl)-acryloylamino]-...)
Affinity DataIC50: 350nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50108881(CHEMBL3596591)
Affinity DataEC50:  390nMAssay Description:Inverse agonist activity at human ROR-alpha transfected in HEK293T cells by Gal4 luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2017
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50147544(2-(2-methoxy-5-(5-(4-(trifluoromethoxy)phenyl)benz...)
Affinity DataIC50: 400nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165615((2-{4-[2-(2,4-Dichloro-phenylcarbamoyl)-vinyl]-phe...)
Affinity DataIC50: 400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165652(2-(2-(4-(3-(4-bromophenyl)acrylamido)-3-fluorophen...)
Affinity DataIC50: 400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165613(2-(2-(4-(3-(4-bromophenyl)acrylamido)-2-chlorophen...)
Affinity DataIC50: 400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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