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TargetTranslocator protein(Human)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22040(Ro5-4864 | 4' Cl-diazepam | 4 -chlorodiazepam ...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to TSPO receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Human)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50378901(CHEMBL1672418)
Affinity DataKd:  10nMAssay Description:Binding affinity to human TSPOMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Human)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054139((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human TSPOMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50409615(CHEMBL5282701)
Affinity DataKd:  3.80nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex mitochondrial membrane incubated for 60 mins by liquid scintillation spectrometer ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50443668(CHEBI:5537 | CHEMBL1290003 | GRANISETRON)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50443668(CHEBI:5537 | CHEMBL1290003 | GRANISETRON)
Affinity DataEC50:  320nMAssay Description:Agonist activity at human wild type 5-HT3A receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50443668(CHEBI:5537 | CHEMBL1290003 | GRANISETRON)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells after 24 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50443668(CHEBI:5537 | CHEMBL1290003 | GRANISETRON)
Affinity DataKd:  0.530nMAssay Description:Binding affinity to human wild type 5-HT3A receptor expressed in HEK293 cells after 24 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50417287(Aloxi | Aurothioglucose | PALONOSETRON | PALONOSET...)
Affinity DataKd:  0.180nMAssay Description:Binding affinity to human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells after 24 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 3A(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50417287(Aloxi | Aurothioglucose | PALONOSETRON | PALONOSET...)
Affinity DataKd:  0.320nMAssay Description:Binding affinity to human wild type 5-HT3A receptor expressed in HEK293 cells after 24 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50009718(CHEMBL7550 | 2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetraz...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.590nMAssay Description:Inhibitory concentration against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50009712(CHEMBL315104 | 5,7-Dimethyl-2-propyl-3-[2'-(2H-tet...)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50417287(Aloxi | Aurothioglucose | PALONOSETRON | PALONOSET...)
Affinity DataIC50: 0.830nMAssay Description:Antagonist activity at human wild type 5-HT3A receptor expressed in HEK293 cells assessed as inhibition of 5-HT-induced response after 45 mins by FLI...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 3A/3B(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50417287(Aloxi | Aurothioglucose | PALONOSETRON | PALONOSET...)
Affinity DataIC50: 0.880nMAssay Description:Antagonist activity at human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells assessed as inhibition of 5-HT-induced response after 45 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50009719(L-158338 | CHEMBL296725 | 7-Methyl-2-propyl-3-[2'-...)
Affinity DataIC50: 1nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50049186(CHEMBL1069 | (S)-3-Methyl-2-{pentanoyl-[2'-(1H-tet...)
Affinity DataIC50: 1.90nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059754(3-Methyl-4-phenyl-quinoline-2-carboxylic acid sec-...)
Affinity DataIC50: 2.10nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059749(3-Methyl-4-phenyl-quinoline-2-carboxylic acid benz...)
Affinity DataIC50: 2.10nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059749(3-Methyl-4-phenyl-quinoline-2-carboxylic acid benz...)
Affinity DataIC50: 2.10nMAssay Description:In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059754(3-Methyl-4-phenyl-quinoline-2-carboxylic acid sec-...)
Affinity DataIC50: 2.10nMAssay Description:In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059749(3-Methyl-4-phenyl-quinoline-2-carboxylic acid benz...)
Affinity DataIC50: 2.10nMAssay Description:In vitro displacement of [3H]PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059754(3-Methyl-4-phenyl-quinoline-2-carboxylic acid sec-...)
Affinity DataIC50: 2.10nMAssay Description:In vitro displacement of [3H]PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059749(3-Methyl-4-phenyl-quinoline-2-carboxylic acid benz...)
Affinity DataIC50: 2.10nMAssay Description:Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059754(3-Methyl-4-phenyl-quinoline-2-carboxylic acid sec-...)
Affinity DataIC50: 2.10nMAssay Description:Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50131729(4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxyli...)
Affinity DataIC50: 2.20nMAssay Description:Displacement of [3H]CB34 from TSPO receptor in rat brain cortex membrane by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataIC50: 2.20nMAssay Description:In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataIC50: 2.20nMAssay Description:In vitro displacement of [3H]PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataIC50: 2.20nMAssay Description:Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataIC50: 2.20nMAssay Description:Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059755(4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxyli...)
Affinity DataIC50: 2.90nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059755(4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxyli...)
Affinity DataIC50: 2.90nMAssay Description:In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059755(4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxyli...)
Affinity DataIC50: 2.90nMAssay Description:In vitro displacement of [3H]PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059755(4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxyli...)
Affinity DataIC50: 2.90nMAssay Description:Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50166995(2-Chloro-3-methyl-quinoline-4-carboxylic acid [7-(...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059758(4-Methyl-1-phenyl-isoquinoline-3-carboxylic acid b...)
Affinity DataIC50: 3.10nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059758(4-Methyl-1-phenyl-isoquinoline-3-carboxylic acid b...)
Affinity DataIC50: 3.10nMAssay Description:In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059758(4-Methyl-1-phenyl-isoquinoline-3-carboxylic acid b...)
Affinity DataIC50: 3.10nMAssay Description:In vitro displacement of [3H]PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059758(4-Methyl-1-phenyl-isoquinoline-3-carboxylic acid b...)
Affinity DataIC50: 3.10nMAssay Description:Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059739(4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxyli...)
Affinity DataIC50: 3.40nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059739(4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxyli...)
Affinity DataIC50: 3.40nMAssay Description:In vitro binding affinity (pIC50) was tested against peripheral benzodiazepine receptor (PBR) in rat.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059739(4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxyli...)
Affinity DataIC50: 3.40nMAssay Description:In vitro displacement of [3H]PK11195 from the peripheral benzodiazepine receptor (PBR) in rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50059739(4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxyli...)
Affinity DataIC50: 3.40nMAssay Description:Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50145961(7-Methyl-2-propyl-3-{4-[3-(2H-tetrazol-5-yl)-pyrid...)
Affinity DataIC50: 4nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50098694(3-[(Benzyl-ethyl-amino)-methyl]-4-phenyl-quinoline...)
Affinity DataIC50: 4.10nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50098694(3-[(Benzyl-ethyl-amino)-methyl]-4-phenyl-quinoline...)
Affinity DataIC50: 4.10nMAssay Description:Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50166984(3-Methyl-2-(4-methyl-piperazin-1-yl)-quinoline-4-c...)
Affinity DataIC50: 4.10nMAssay Description:Inhibitory concentration against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50145972(2-Amino-4-[4-(5,7-dimethyl-2-propyl-imidazo[4,5-b]...)
Affinity DataIC50: 4.20nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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