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TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataKi:  0.0620nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  0.0620nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366785(NELFINAVIR)
Affinity DataKi:  0.140nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  0.240nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataKi:  0.280nMAssay Description:Tested for ability to compete with dansylamide for binding to human erythrocyte carbonic-anhydrase-II (HCA-II)More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012229(5-Thiomorpholin-4-ylmethyl-thieno[2,3-b]thiophene-...)
Affinity DataKi:  0.440nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017725((S)-4-Isobutylamino-7,7-dioxo-4,5,6,7-tetrahydro-7...)
Affinity DataKi:  0.600nMAssay Description:Tested for ability to compete with dansylamide for binding to human erythrocyte carbonic-anhydrase-II (HCA-II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50041029((S)-4-Isobutylamino-7,7-dioxo-4,5,6,7-tetrahydro-7...)
Affinity DataKi:  0.600nMAssay Description:Tested for ability to compete with dansylamide for binding to human erythrocyte carbonic-anhydrase-II (HCA-II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124914(CHEMBL161180 | N-(3,5-Dichloro-benzyl)-4-trifluoro...)
Affinity DataKi:  0.600nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077035(1-(1-{2-[4-Morpholin-4-yl-2-(2,2,2-trifluoro-ethox...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity for rat uterine oxytocin receptor (rOTr)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124885((E)-N-(2-Methoxy-benzyl)-3-phenyl-acrylamidine | C...)
Affinity DataKi:  0.700nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077032(1-(1-{2-[4-(1-Acetyl-piperidin-4-yloxy)-2-(2,2,2-t...)
Affinity DataKi:  0.710nMAssay Description:Binding affinity for rat uterine oxytocin receptor (rOTr)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064709(1-(1-{4-[1-(2-Ethyl-4,6-dimethyl-1-oxy-pyridin-3-y...)
Affinity DataKi:  0.810nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064738(1-(1-{5-Fluoro-2-methoxy-4-[1-(1-oxy-2-trifluorome...)
Affinity DataKi:  0.820nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077035(1-(1-{2-[4-Morpholin-4-yl-2-(2,2,2-trifluoro-ethox...)
Affinity DataKi:  0.860nMAssay Description:Binding affinity for human oxytocin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012211(5-{[Bis-(2-methoxy-ethyl)-amino]-methyl}-thieno[3,...)
Affinity DataKi:  0.950nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50043900(3-{2-[Bis-(2-methoxy-ethyl)-amino]-ethyl}-4,4-diox...)
Affinity DataKi:  0.970nMAssay Description:Tested for ability to compete with dansylamide for binding to human erythrocyte carbonic-anhydrase-II (HCA-II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012231(5-Morpholin-4-ylmethyl-thieno[2,3-b]thiophene-2-su...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064734(1-(1-{5-Fluoro-2-methoxy-4-[1-(2,4,6-trimethyl-1-o...)
Affinity DataKi:  1nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077041(1-(1-{2-[4-(1-Cyclopropylmethyl-piperidin-4-yloxy)...)
Affinity DataKi:  1nMAssay Description:Binding affinity for human oxytocin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064735(1-(1-{4-[1-(2,4-Dimethyl-1-oxy-pyridin-3-ylmethyl)...)
Affinity DataKi:  1nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064733(1-(1-{5-Fluoro-2-methoxy-4-[1-(2-methyl-1-oxy-pyri...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077041(1-(1-{2-[4-(1-Cyclopropylmethyl-piperidin-4-yloxy)...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for rat uterine oxytocin receptor (rOTr)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50043913(3-(2-Hydroxy-ethyl)-4,4-dioxo-1,2,3,4-tetrahydro-4...)
Affinity DataKi:  1.20nMAssay Description:Tested for ability to compete with dansylamide for binding to human erythrocyte carbonic-anhydrase-II (HCA-II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004551(5-Morpholin-4-ylmethyl-thieno[2,3-b]furan-2-sulfon...)
Affinity DataKi:  1.20nMAssay Description:Compound was evaluated for the inhibition of dansylamide at human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124909(CHEMBL159744 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...)
Affinity DataKi:  1.20nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064719(1-(1-{5-Fluoro-2-methoxy-4-[1-(1-oxy-4-trifluorome...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012209(5-{[Bis-(2-methoxy-ethyl)-amino]-methyl}-thieno[2,...)
Affinity DataKi:  1.34nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064741(1-(1-{2-Methoxy-4-[1-(1-oxy-2-trifluoromethyl-pyri...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003252(4-(4-Morpholin-4-ylmethyl-benzenesulfonyl)-thiophe...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077037(1-(1-{2-[4-(2-Morpholin-4-yl-ethoxy)-2-(2,2,2-trif...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for human oxytocin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077032(1-(1-{2-[4-(1-Acetyl-piperidin-4-yloxy)-2-(2,2,2-t...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for human oxytocin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012227(5-{[Bis-(1-methyl-2-oxo-ethyl)-amino]-methyl}-thie...)
Affinity DataKi:  1.49nMAssay Description:The compound was tested for in vitro binding affinity against human Carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064725(1-(1-{4-[1-(2-Ethyl-4,6-dimethyl-1-oxy-pyridin-3-y...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012208(5-{1-[[2-(2-Methoxy-ethoxy)-ethyl]-(2-methoxy-ethy...)
Affinity DataKi:  1.54nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012207(5-{[[2-(2-Methoxy-ethoxy)-ethyl]-(2-methoxy-ethyl)...)
Affinity DataKi:  1.58nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064736(1-(1-{5-Fluoro-2-methoxy-4-[1-((S)-1-oxy-5,6,7,8-t...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012225(5-[(2-Fluoro-ethylamino)-methyl]-thieno[2,3-b]thio...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064717(1-(1-{5-Fluoro-2-methoxy-4-[1-(1-oxy-5,6,7,8-tetra...)
Affinity DataKi:  2nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012232(5-[(2-Methylsulfanyl-ethylamino)-methyl]-thieno[2,...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077032(1-(1-{2-[4-(1-Acetyl-piperidin-4-yloxy)-2-(2,2,2-t...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards rat liver Vasopressin V1a receptor by using functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064737(1-(1-{4-[1-(2-Ethyl-1-oxy-pyridin-3-ylmethyl)-pipe...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077037(1-(1-{2-[4-(2-Morpholin-4-yl-ethoxy)-2-(2,2,2-trif...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity for rat uterine oxytocin receptor (rOTr)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003246(4-(3-Dimethylaminomethyl-4-hydroxy-benzenesulfonyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064740(1-(1-{5-Fluoro-2-methoxy-4-[1-((R)-1-oxy-5,6,7,8-t...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064739(1-{1-[5-Fluoro-2-methoxy-4-(1-quinolin-5-yl-piperi...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003246(4-(3-Dimethylaminomethyl-4-hydroxy-benzenesulfonyl...)
Affinity DataKi:  2.34nMAssay Description:Compound was tested in vitro for binding affinity against human carbonic anhydrase II; (ki*10e-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012217(5-Sulfamoyl-thieno[2,3-b]thiophene-2-carboxylic ac...)
Affinity DataKi:  2.39nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077039(1-(1-{2-[4-(1-Acetyl-piperidin-4-yloxy)-2-trifluor...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity for human oxytocin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50064730(1-(1-{2-Methoxy-4-[1-(1-oxy-2-propyl-pyridin-3-ylm...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity for cloned human oxytocin receptor (OT-R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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