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Found 169 with Last Name = 'minond' and Initial = 'd'
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataKi:  824nMAssay Description:Noncompetitive inhibition of human full length recombinant MMP13 using triple-helical fTHP-15 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361640(CHEMBL1515648)
Affinity DataKi:  1.53E+3nMAssay Description:Noncompetitive inhibition of human full length recombinant MMP13 using triple-helical fTHP-15 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM40467(2-[(4-chlorobenzyl)thio]-1,5,6,7-tetrahydrocyclope...)
Affinity DataKi:  3.80E+3nMAssay Description:Noncompetitive inhibition of human full length recombinant MMP13 using triple-helical fTHP-15 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50203527((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)
Affinity DataIC50:  14nMAssay Description:Inhibition of porcine spleen ADAM17More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50265079((4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,...)
Affinity DataIC50:  14nMAssay Description:Non-competitive inhibition of full-length recombinant human MMP-13 assessed as fTHP-15 substrate hydrolysisMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50203527((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  70nMAssay Description:Inhibition of full-length recombinant human MMP-13 assessed as bovine type-2 collagen hydrolysis after 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  110nMAssay Description:Non-competitive inhibition of full-length recombinant human MMP-13 assessed as fTHP-15 substrate hydrolysisMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Eutropics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50442292(CHEMBL2442249)
Affinity DataIC50:  310nMAssay Description:Inhibition of human GST-tagged Mcl1 expressed in Escherichia coli BL21 using FITC-AHA-MRPEIWIAQELRRIGDEFNA-[NH2] after 20 mins by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  400nMAssay Description:Inhibition of full-length recombinant human MMP-13 assessed as bovine type-2 collagen hydrolysis after 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Eutropics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50420775(CHEMBL581146 | TCMDC-125324)
Affinity DataIC50:  400nMAssay Description:Inhibition of human GST-tagged Mcl1 expressed in Escherichia coli BL21 using FITC-AHA-MRPEIWIAQELRRIGDEFNA-[NH2] after 20 mins by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Eutropics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50442293(CHEMBL2442248)
Affinity DataIC50:  500nMAssay Description:Inhibition of human GST-tagged Mcl1 expressed in Escherichia coli BL21 using FITC-AHA-MRPEIWIAQELRRIGDEFNA-[NH2] after 20 mins by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50031314(CHEMBL473326)
Affinity DataIC50:  700nMAssay Description:Inhibition of full-length recombinant human MMP-13 assessed as bovine type-2 collagen hydrolysis after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50203527((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)
Affinity DataIC50:  772nMAssay Description:Inhibition of human MT1-MMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50247214(5-(3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazol-5-yl)...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50203527((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of ADAM17 in human A549 cells assessed as potentiation of gefitinib-mediated inhibition of cell viability by measuring gefitinib IC50 at 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Eutropics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50442294(CHEMBL2442247)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human GST-tagged Mcl1 expressed in Escherichia coli BL21 using FITC-AHA-MRPEIWIAQELRRIGDEFNA-[NH2] after 20 mins by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM29642(4-[(5-thiophen-2-yl-2-thiophenyl)methylideneamino]...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104622(CHEMBL3593550)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of ADAM17 in human A549 cells assessed as potentiation of gefitinib-mediated inhibition of cell viability by measuring gefitinib IC50 at 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50247207(2-(biphenyl-4-ylsulfonamido)pentanedioic acid | CH...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361640(CHEMBL1515648)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of full-length recombinant human MMP-13 assessed as bovine type-2 collagen hydrolysis after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  2.40E+3nMAssay Description:Non-competitive inhibition of full-length recombinant human MMP-13 assessed as fTHP-15 substrate hydrolysisMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Eutropics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381(2-[2-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(pyri...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human GST-tagged Mcl1 expressed in Escherichia coli BL21 using FITC-AHA-MRPEIWIAQELRRIGDEFNA-[NH2] after 20 mins by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50265079((4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50265079((4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin) using (S)-mephentoin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50247209(5-cyclohexyl-5-(2-(pyridin-4-yl)ethyl)pyrimidine-2...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50265079((4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50265079((4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) using amodiaquine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50265079((4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50265079((4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin) using dextromethophan substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50265079((4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin) using tacrin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50265079((4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,...)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin) using bupropion substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361640(CHEMBL1515648)
Affinity DataIC50:  2.80E+3nMAssay Description:Non-competitive inhibition of full-length recombinant human MMP-13 assessed as fTHP-15 substrate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50247466(CHEMBL462629 | cid_5600879 | ethyl 2-cyano-2-(quin...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50031314(CHEMBL473326)
Affinity DataIC50:  3.40E+3nMAssay Description:Non-competitive inhibition of full-length recombinant human MMP-13 assessed as fTHP-15 substrate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50247261(5-(3,5-dimethoxyphenyl)-N-(4-fluorobenzo[d]thiazol...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50247465(5-phenyl-5-(2-(pyridin-4-yl)ethyl)pyrimidine-2,4,6...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin) using tacrin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50247262(3-(2-methoxy-6-(4-methoxyphenyl)pyridin-3-yl)-5-o-...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104622(CHEMBL3593550)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM40478(2-[(4-methoxyphenyl)methylsulfanyl]-6-methyl-1H-py...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104620(CHEMBL3593551)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50247461(CHEMBL460516 | N-(2,3-dihydro-1H-inden-5-yl)-2-(5-...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50247490(4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid ...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104631(CHEMBL3593541)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104621(CHEMBL3235911)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104624(CHEMBL3593548)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104623(CHEMBL3593549)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM50104633(CHEMBL3593361)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) preincubated for 30 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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