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TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775((3R,4R)3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-di...)
Affinity DataKi:  0.0430nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130563((3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphe...)
Affinity DataKi:  0.0591nMAssay Description:Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  0.0700nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775((3R,4R)3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-di...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]diprenorphine from cloned human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775((3R,4R)3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-di...)
Affinity DataKi:  0.150nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50219921(4-(4-((phenethylamino)methyl)phenoxy)benzamide | C...)
Affinity DataKi:  0.150nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.153nMAssay Description:Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026614(CHEMBL575508)
Affinity DataKi:  0.153nMAssay Description:Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045792(3-[3,4-Dimethyl-1-(4-methyl-pent-4-enyl)-piperidin...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cells in presence of high sodium by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]diprenorphine from cloned human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045733(3-[3,4-Dimethyl-1-(3-thiophen-2-yl-propyl)-piperid...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045733(3-[3,4-Dimethyl-1-(3-thiophen-2-yl-propyl)-piperid...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity towards mu-opioid receptor by displacement of [3H]-NAL at 10 nM from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50471498(CHEMBL150450)
Affinity DataKi:  0.240nMAssay Description:Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045742(3-[3,4-Dimethyl-1-(3-thiophen-3-yl-propyl)-piperid...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045742(3-[3,4-Dimethyl-1-(3-thiophen-3-yl-propyl)-piperid...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity towards mu-opioid receptor by displacement of [3H]-NAL at 10 nM from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045738((3R,4R)3-(1-Hexyl-3,4-dimethyl-piperidin-4-yl)-phe...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045779(3-[3,4-Dimethyl-1-(4-methyl-pentyl)-piperidin-4-yl...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50219921(4-(4-((phenethylamino)methyl)phenoxy)benzamide | C...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cells in presence of high sodium by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045776(CHEMBL982 | JF-1 | NALMEFENE | Nalmetrene | ORF-11...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045780(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045748(3-{1-[2-(3-Chloro-phenyl)-ethyl]-3,4-dimethyl-pipe...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775((3R,4R)3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-di...)
Affinity DataKi:  0.320nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50471487(CHEMBL436075)
Affinity DataKi:  0.330nMAssay Description:Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045781(1-Cyclohexyl-3-[4-(3-hydroxy-phenyl)-3,4-dimethyl-...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50471494(CHEMBL153723)
Affinity DataKi:  0.360nMAssay Description:Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045791(3-[1-(3-Cyclopentyl-propyl)-3,4-dimethyl-piperidin...)
Affinity DataKi:  0.370nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50471499(CHEMBL345774)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50471485(Vedaclidine)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775((3R,4R)3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-di...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045786(3-[1-(3-Cyclopentyl-3-hydroxy-propyl)-3,4-dimethyl...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50471492(CHEMBL150293)
Affinity DataKi:  0.420nMAssay Description:Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50219918(5-(4-((phenethylamino)methyl)phenoxy)picolinamide ...)
Affinity DataKi:  0.440nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50471495(CHEMBL153478)
Affinity DataKi:  0.440nMAssay Description:Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50471486(CHEMBL343731)
Affinity DataKi:  0.450nMAssay Description:Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045785(3-[1-(3-Cyclohexyl-propyl)-3,4-dimethyl-piperidin-...)
Affinity DataKi:  0.490nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033155(3-(3-Butylsulfanyl-pyrazin-2-yl)-1-aza-bicyclo[2.2...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045735(3-[1-(3-Hydroxy-3-thiophen-2-yl-propyl)-3,4-dimeth...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045735(3-[1-(3-Hydroxy-3-thiophen-2-yl-propyl)-3,4-dimeth...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50346474((R)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-pyrrolidi...)
Affinity DataKi:  0.502nMAssay Description:Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045733(3-[3,4-Dimethyl-1-(3-thiophen-2-yl-propyl)-piperid...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045733(3-[3,4-Dimethyl-1-(3-thiophen-2-yl-propyl)-piperid...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50358169(CHEMBL1921845)
Affinity DataKi:  0.565nMAssay Description:Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.590nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50358168(CHEMBL1921844)
Affinity DataKi:  0.617nMAssay Description:Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045770(3-(1-Heptyl-3,4-dimethyl-piperidin-4-yl)-phenol | ...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]-Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045773(3-[3,4-Dimethyl-1-(3-o-tolyl-propyl)-piperidin-4-y...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045770(3-(1-Heptyl-3,4-dimethyl-piperidin-4-yl)-phenol | ...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity towards mu opioid receptor by displacement of [3H]-NAL from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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