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TargetSerine racemase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50055467(CHEBI:17576 | CHEMBL3317781)
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity to serine recemase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM14673(Fragment 3 | Malonic Acid | propanedioic acid)
Affinity DataKi:  3.30E+4nMAssay Description:Binding affinity to serine recemase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM18133(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
Affinity DataKi:  3.66E+5nMAssay Description:Binding affinity to serine recemase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50509698(3-Isomangostin | CHEMBL464119)
Affinity DataIC50:  52nMAssay Description:Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50214969(1,3,6-Trihydroxy-7-methoxy-2,8-bis-(3-methyl-but-2...)
Affinity DataIC50:  470nMAssay Description:Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP ...More data for this Ligand-Target Pair
TargetDeath-associated protein kinase 1(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM26658(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...)
Affinity DataIC50:  1.60E+3nMAssay Description:Displacement of ANS from DAPK1 catalytic domain (1 to 285) (unknown origin) after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50509700(CHEMBL506229)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50352564(CHEMBL1825141)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241453(1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)-9...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM36880(2,2'-THIOBIS(4,6-DICHLOROPHENOL) | 2,4-dichlor...)
Affinity DataIC50:  2.40E+3nMAssay Description:Stabilization of TTR V3OM mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance m...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  2.60E+3nMAssay Description:Stabilization of TTR V3OM mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance m...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50509699(CHEMBL4440642)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM36880(2,2'-THIOBIS(4,6-DICHLOROPHENOL) | 2,4-dichlor...)
Affinity DataIC50:  3.00E+3nMAssay Description:Stabilization of wild type TTR (unknown origin) expressed in Escherichia coli assessed as reduction in methanol-induced aggregation incubated for 60 ...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50108877((3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone |...)
Affinity DataIC50:  3.20E+3nMAssay Description:Stabilization of TTR V3OM mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance m...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM58491(5-[2,3-bis(chloranyl)phenoxy]-6-chloranyl-2-methyl...)
Affinity DataIC50:  3.50E+3nMAssay Description:Stabilization of TTR V3OM mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance m...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50:  3.50E+3nMAssay Description:Stabilization of TTR V3OM mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance m...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM32018(1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE | 4,5-diaceto...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568451(CHEMBL4850762)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568449(CHEMBL4851268)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568444(CHEMBL4866842)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 1(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  8.90E+3nMAssay Description:Displacement of ANS from DAPK1 catalytic domain (1 to 285) (unknown origin) after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568450(CHEMBL4855105)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568429(CHEMBL4860573)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568442(CHEMBL4859052)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50530238(1,4,7,10,13,16-Hexaoxacyclooctadecane | 1,4,7,10,1...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 5 uM in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241453(1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)-9...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
TargetDeath-associated protein kinase 1(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM7462(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Displacement of ANS from DAPK1 catalytic domain (1 to 285) (unknown origin) after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50530238(1,4,7,10,13,16-Hexaoxacyclooctadecane | 1,4,7,10,1...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 5 uM in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568441(CHEMBL4857993)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568425(CHEMBL4870376)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 1(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM26658(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of DAPK1 (unknown origin) using ZIPtide as substrate by fluorescence assay in presence of ATP, MgCl2More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568434(CHEMBL4849950)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568447(CHEMBL4874413)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM32021(4,5-bis(oxidanyl)-9,10-bis(oxidanylidene)anthracen...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568427(CHEMBL4864788)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 5 uM in presen...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 5 uM in presen...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM67454(1,2,4-trihydroxy-9,10-anthraquinone | 1,2,4-trihyd...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568432(CHEMBL4864022)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568448(CHEMBL4875739)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568443(CHEMBL4866802)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568445(CHEMBL4868175)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568440(CHEMBL4861683)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50311742(8-DEOXYGARTANIN | 8-desoxygartanin | CHEMBL488606)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50530238(1,4,7,10,13,16-Hexaoxacyclooctadecane | 1,4,7,10,1...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 100 mM in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50530238(1,4,7,10,13,16-Hexaoxacyclooctadecane | 1,4,7,10,1...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 100 mM in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50568433(CHEMBL4876565)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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