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TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072292((3S,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072285((3R,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072289((3S,3aR,6aS)-3-(4-Methyl-2-oxo-pent-3-enyl)-hexahy...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072283((3S,3aR,6aS)-3-Benzyl-hexahydro-cyclopenta[b]furan...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290670(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218255(CHEMBL290100)
Affinity DataIC50:  1nMAssay Description:Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218255(CHEMBL290100)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072286((3R,3aR,6aS)-3-Benzyl-hexahydro-cyclopenta[b]furan...)
Affinity DataIC50:  2nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218257(CHEMBL69874)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290675(5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-mercapto...)
Affinity DataIC50:  3nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50100087(5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfony...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50100087(5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfony...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50476508(CHEMBL234487)
Affinity DataIC50:  3nMAssay Description:Inhibition of MAPK p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  3nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50219014(CHEMBL149559)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human phosphodiesterase 4 from U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072284((1S,2R,4aR,6aS,6bS,7R,9aS,10aS)-2-Acetoxy-1,4a,6a,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  5nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290668(2-Mercapto-5-methanesulfonylamino-pentanoic acid [...)
Affinity DataIC50:  6nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072285((3R,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50:  6nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396920(US9981963, Compound 11)
Affinity DataIC50:  6nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218258(CHEMBL70146)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50218245(CHEMBL65799)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218245(CHEMBL65799)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50476509(CHEMBL234486)
Affinity DataIC50:  7nMAssay Description:Inhibition of MAPK p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50114418(8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...)
Affinity DataIC50:  7nMAssay Description:Inhibition of rolipram binding to PDE4 of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072290((3S,3aR,6aS)-3-Allyl-hexahydro-cyclopenta[b]furan-...)
Affinity DataIC50:  7nMAssay Description:Compound was evaluated for the inhibition of ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50218257(CHEMBL69874)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218246(CHEMBL68323)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  9nMAssay Description:Inhibition of matrix metalloproteinase-9, MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50213867(CHEMBL329303)
Affinity DataIC50:  9nMAssay Description:Inhibition of rolipram bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396936(US9981963, Compound 31)
Affinity DataIC50:  9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396916(US9981963, Compound 7)
Affinity DataIC50:  9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396918(US9981963, Compound 9)
Affinity DataIC50:  9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396919(US9981963, Compound 10)
Affinity DataIC50:  9nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MAPK p38More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072292((3S,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50:  10nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50290671((S)-4-(2,5-Dioxo-pyrrolidin-1-yl)-2-mercapto-N-[(R...)
Affinity DataIC50:  10nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396924(US9981963, Compound 15)
Affinity DataIC50:  10nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396934(US9981963, Compound 25)
Affinity DataIC50:  14nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396922(US9981963, Compound 13)
Affinity DataIC50:  14nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50290670(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  14nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50219013(CHEMBL343205)
Affinity DataIC50:  14nMAssay Description:Inhibition of human phosphodiesterase 4 from U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100087(5-Phenyl-2-[4-(pyridine-4-carbonyl)-benzenesulfony...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50290667(5-Mercapto-5-[(S)-3-methyl-1-((S)-1-methylcarbamoy...)
Affinity DataIC50:  15nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50290669((S)-2-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-m...)
Affinity DataIC50:  15nMAssay Description:Inhibition of matrix metalloproteinase-8, MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM396914(US9981963, Compound 5)
Affinity DataIC50:  16nMAssay Description:Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na3VO4, 5 mM MgCl2, 0.0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50214164(CHEMBL100011)
Affinity DataIC50:  17nMAssay Description:Inhibition of rolipram bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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