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Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193786(4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13760((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 3nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192679((3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193785((3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193785((3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193786(4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13756((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13761((1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylprop...)
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13768(N-[(1R,2S,5R,7S)-5-[(carbamoylmethyl)carbamoyl]ada...)
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192791(2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...)
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13756((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)
Affinity DataIC50: 5nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192679((3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192792(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13760((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13761((1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylprop...)
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 6nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192791(2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193785((3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193785((3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195289(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of cortisol formation by fluorescent polarization immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13757((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 8nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13757((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 8nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13769(2-(4-chlorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-{[...)
Affinity DataIC50: 8nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192679((3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13772(2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R...)
Affinity DataIC50: 10nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192797(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidaz...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193795(34-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193798(6-((1-cycloheptyl-5-oxopyrrolidin-3-yl)methoxy)nic...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13772(2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R...)
Affinity DataIC50: 11nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13766((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 11nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192684((3s,9s)-9-(2-(5-cyanopyridin-2-yloxy)-2-methylprop...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192797(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidaz...)
Affinity DataIC50: 11nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192792(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 11nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13768(N-[(1R,2S,5R,7S)-5-[(carbamoylmethyl)carbamoyl]ada...)
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13762(4-({[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methyl...)
Affinity DataIC50: 12nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13769(2-(4-chlorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-{[...)
Affinity DataIC50: 13nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192686(4-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13767((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 14nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192798(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193787(4-[3,3-dmethyl-2-oxo-4-(5-trifluoromethyl-pyridin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13758((1R,3R,4S,7S)-4-[2-(3-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 15nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13762(4-({[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methyl...)
Affinity DataIC50: 15nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192673(2-(4-chlorophenoxy)-N-(1-hydroxy-2-oxatricyclo[3.3...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193795(34-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethy...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13764((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 16nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195504((4-amino-3,5-dichlorophenyl)(1,3,3-trimethyl-6-aza...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells by fluorescence polarization immuno-assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13764((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 18nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192791(2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193787(4-[3,3-dmethyl-2-oxo-4-(5-trifluoromethyl-pyridin-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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