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TargetCannabinoid receptor 2(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50491576(CHEMBL2381811)
Affinity DataEC50:  351nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in CHO cell membrane assessed as increase in forskolin-stimulated cAMP production by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50491561(CHEMBL2381809)
Affinity DataEC50:  95nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in CHO cell membrane assessed as increase in forskolin-stimulated cAMP production by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50491596(CHEMBL2381786)
Affinity DataEC50:  195nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in CHO cell membrane assessed as increase in forskolin-stimulated cAMP production by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50126720((S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-ox...)
Affinity DataKd:  3.60nMAssay Description:Equilibrium constant for P2X purinoceptor 7 expressed in HEK 293 cells at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50126720((S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-ox...)
Affinity DataKd:  3.60nMAssay Description:Maximum binding affinity towards P2X purinoceptor 7 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50080540(CHEMBL57997 | CHEMBL203347 | (2-amino-4,5,6,7-tetr...)
Affinity DataKd:  4.60E+3nMAssay Description:Affinity for adenosine A1 receptor in CHO membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253852((2-amino-4-((4-methylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253308((2-amino-4-((4-(pyrimidin-2-yl)piperazin-1-yl)meth...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253307((2-amino-4-((4-(pyridin-2-yl)piperazin-1-yl)methyl...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253928((2-amino-4-((4-(4-(trifluoromethyl)phenyl)piperazi...)
Affinity DataKd:  1.90nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253927(4-(4-((5-amino-4-(4-chlorobenzoyl)thiophen-3-yl)me...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253926((2-amino-4-((4-(benzo[d][1,3]dioxol-5-yl)piperazin...)
Affinity DataKd:  1.90nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253925((2-amino-4-((4-p-tolylpiperazin-1-yl)methyl)thioph...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253892((2-amino-4-((4-(4-chlorophenyl)piperazin-1-yl)meth...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253891((2-amino-4-((4-(4-fluorophenyl)piperazin-1-yl)meth...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253890((2-amino-4-((4-benzylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.70nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253889((2-amino-4-((4-phenylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.90nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253888((2-amino-4-((4-cyclohexylpiperazin-1-yl)methyl)thi...)
Affinity DataKd:  1.90nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50080550((2-amino-4,5-dimethylthien-3-yl)-[3-(trifluorometh...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253852((2-amino-4-((4-methylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.20nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253308((2-amino-4-((4-(pyrimidin-2-yl)piperazin-1-yl)meth...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253307((2-amino-4-((4-(pyridin-2-yl)piperazin-1-yl)methyl...)
Affinity DataKd:  1.20nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253928((2-amino-4-((4-(4-(trifluoromethyl)phenyl)piperazi...)
Affinity DataKd:  1nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253927(4-(4-((5-amino-4-(4-chlorobenzoyl)thiophen-3-yl)me...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253926((2-amino-4-((4-(benzo[d][1,3]dioxol-5-yl)piperazin...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253925((2-amino-4-((4-p-tolylpiperazin-1-yl)methyl)thioph...)
Affinity DataKd:  1nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253892((2-amino-4-((4-(4-chlorophenyl)piperazin-1-yl)meth...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253891((2-amino-4-((4-(4-fluorophenyl)piperazin-1-yl)meth...)
Affinity DataKd:  1nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253890((2-amino-4-((4-benzylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253889((2-amino-4-((4-phenylpiperazin-1-yl)methyl)thiophe...)
Affinity DataKd:  1nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50253888((2-amino-4-((4-cyclohexylpiperazin-1-yl)methyl)thi...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50080550((2-amino-4,5-dimethylthien-3-yl)-[3-(trifluorometh...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50348175(CHEMBL1800865)
Affinity DataKd:  4.90nMAssay Description:Binding affinity to human recombinant A3 adenosine receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202567(1-deoxy-1-{2-chloro-6-[N'-(5-methyl-isoxazole-3-ca...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202569(1-deoxy-1-{2-chloro-6-[N'-(5-phenyl-isoxazole-3-ca...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  160nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202568(N'-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3...)
Affinity DataEC50:  450nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202564(1-deoxy-1-{2-chloro-6-[N'-(5-methyl-thiophene-2-ca...)
Affinity DataEC50:  175nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202577(1-deoxy-1-{2-chloro-6-[N'-(furan-2-carbonyl)-hydra...)
Affinity DataEC50:  210nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202575(1-deoxy-1-{2-chloro-6-[N'-(2-thiophen-2-yl-acetyl)...)
Affinity DataEC50:  603nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202561(1-deoxy-1-[6-(N'-benzoylhydrazino)-9H-purin-9-yl]-...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202573(1-deoxy-1-{6-[N'-(pyridine-3-carbonyl)-hydrazino]-...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202565(N'-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3...)
Affinity DataEC50:  200nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202570(N'-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydr...)
Affinity DataEC50:  82nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202574(1-deoxy-1-{6-[N'-(5-bromo-furan-2-carbonyl)-hydraz...)
Affinity DataEC50:  369nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202562(1-deoxy-1-{6-[N'-(1-methyl-4-nitro-1H-imidazole-2-...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202578(N'-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydr...)
Affinity DataEC50:  273nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202576(1-deoxy-1-[6-(N'-benzoyl-hydrazino)-2-chloro-9H-pu...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202563(1-deoxy-1-[6-(N'-(4-chlorobenzoyl)hydrazino)-9H-pu...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50202572(N'-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3...)
Affinity DataEC50:  359nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
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