Compile Data Set for Download or QSAR
Found 1712 with Last Name = 'mortimore' and Initial = 'm'
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of aurora A kinaseChecked by AuthorMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277679(CHEMBL484006 | N-(4-(4-(4-tert-butylpiperazin-1-yl...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293699(CHEMBL554941 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277678(CHEMBL485186 | N-(4-(4-(4-cyclopropylpiperazin-1-y...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277640(CHEMBL485351 | N-(4-(4-(4-ethylpiperazin-1-yl)-6-(...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293690(CHEMBL564941 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293671(CHEMBL561421 | N-(4-(4-(5-cyclopropyl-1H-pyrazol-3...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293689(CHEMBL549668 | N-methyl-N-(4-(4-(5-methyl-1H-pyraz...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293669(CHEMBL564449 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293686(CHEMBL559900 | N-(5-methyl-1H-pyrazol-3-yl)-2-(nap...)
Affinity DataKi:  1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277679(CHEMBL484006 | N-(4-(4-(4-tert-butylpiperazin-1-yl...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277586(CHEMBL484951 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277639(CHEMBL484609 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277637(CHEMBL482778 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293687(CHEMBL552033 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293682(2-(3,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293680(2-(2,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293698(CHEMBL563682 | N-(4-(4-(azetidin-1-yl)-6-(5-methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293693(CHEMBL557279 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293700(CHEMBL560630 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi: <3nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293679(2-(2,3-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  3nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277638(CHEMBL482779 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293697(CHEMBL557682 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293695(CHEMBL561617 | N-(4-(4-cyclopropyl-6-(5-methyl-1H-...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277585(CHEMBL484950 | N-(4-(4-(3-methyl-1H-pyrazol-5-ylam...)
Affinity DataKi:  4nMAssay Description:Inhibition of aurora A kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293677(2-(3-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  4nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277585(CHEMBL484950 | N-(4-(4-(3-methyl-1H-pyrazol-5-ylam...)
Affinity DataKi:  4nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of aurora C kinaseChecked by AuthorMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293676(2-(2-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  5nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293681(2-(2,6-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  5nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293694(CHEMBL560556 | N-(4-(4-methyl-6-(5-methyl-1H-pyraz...)
Affinity DataKi:  5.10nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50341751(3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfon...)
Affinity DataKi:  6nMAssay Description:Competitive inhibition of full length recombinant ATR Morrison equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293678(2-(4-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  6nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277586(CHEMBL484951 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  8nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293680(2-(2,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  8nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293688(CHEMBL556460 | tert-butyl 4-(4-(5-methyl-1H-pyrazo...)
Affinity DataKi:  9nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50293684(2-(4-methoxyphenylthio)-N-(5-methyl-1H-pyrazol-3-y...)
Affinity DataKi:  9nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277678(CHEMBL485186 | N-(4-(4-(4-cyclopropylpiperazin-1-y...)
Affinity DataKi:  9.5nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM420503(US10479784, Compound IA-18 | US10961232, Compound ...)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM489350(US10961232, Compound IA-19)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM420505(US10479784, Compound IA-20 | US10961232, Compound ...)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM420509(4-(5-amino-6-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazi...)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM420513(US10479784, Compound IA-26 | US10961232, Compound ...)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM489359(US10961232, Compound IA-28)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM420516(US10479784, Compound IA-29 | US10961232, Compound ...)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM420517(US10479784, Compound IA-30 | US10961232, Compound ...)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM489362(US10961232, Compound IA-31)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM489365(US10961232, Compound IA-34)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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