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TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358999(CHEMBL1923892)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35767(cis-1,2-diaminocyclohexane derivative, 5h)
Affinity DataIC50: 0.430nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50359000(CHEMBL1923893)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50359001(CHEMBL1923894)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50359002(CHEMBL1923895)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358998(CHEMBL1923891)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358982(CHEMBL1923876)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340866(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358997(CHEMBL1921822)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358994(CHEMBL1923888)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35751(cis-1,2-diaminocyclohexane derivative, 8h)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35769(cis-1,2-diaminocyclohexane derivative, 5j)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358993(CHEMBL1923887)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50359003(CHEMBL1923896)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338329(N-(2-{3-[(5-Chlorothiophen-2-yl)carbonylamino]meth...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of factor 10a by S2222 chromogenic substrate assay by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338329(N-(2-{3-[(5-Chlorothiophen-2-yl)carbonylamino]meth...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255631(N-[(1R,2R,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340864(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340874(3-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358970(CHEMBL1923795)
Affinity DataIC50: 2nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358991(CHEMBL1923885)
Affinity DataIC50: 2nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35756(cis-1,2-diaminocyclohexane derivative, 8m)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358976(CHEMBL1923801)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255577(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340872(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255205(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358995(CHEMBL1923889)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358992(CHEMBL1923886)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255207(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340868(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM109264(US8609710, 40)
Affinity DataIC50: 2.60nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
Go to US Patent

TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255159(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340876(1-((4-(5-chloro-1H-indole-2-carboxamido)-3-(5-meth...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255204(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358981(CHEMBL1923875)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358987(CHEMBL1923881)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35762(cis-1,2-diaminocyclohexane derivative, 5c)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetShort transient receptor potential channel 6(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273013(CHEMBL4129456)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2020
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35759(cis-1,2-diaminocyclohexane derivative, 8p)
Affinity DataIC50: 3.20nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35765(cis-1,2-diaminocyclohexane derivative, 5f)
Affinity DataIC50: 3.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35773(cis-1,2-diaminocyclohexane derivative, 48)
Affinity DataIC50: 3.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255576(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35753(cis-1,2-diaminocyclohexane derivative, 8j)
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255206(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255575(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340870(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50358972(CHEMBL1923797)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10a using S-2222 as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
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