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TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50325037(6-(ethyl(8-methyl-7-oxo-5-(trifluoromethyl)-7,8-di...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human RXRalpha expressed in human COS7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50325038(6-(ethyl(8-ethyl-7-oxo-5-(trifluoromethyl)-7,8-dih...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human RXRalpha expressed in human COS7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50325039(6-(ethyl(1-isobutyl-2-oxo-4-(trifluoromethyl)-1,2-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human RXRalpha expressed in human COS7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50429862(CHEMBL2146900)
Affinity DataEC50:  367nMAssay Description:Partial agonist activity at RXRalpha (unknown origin) expressed in COS1 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50429863(CHEMBL2332885)
Affinity DataEC50:  633nMAssay Description:Partial agonist activity at RXRalpha (unknown origin) expressed in COS1 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50429864(CHEMBL2332886)
Affinity DataEC50:  155nMAssay Description:Partial agonist activity at RXRalpha (unknown origin) expressed in COS1 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50429865(CHEMBL2332890)
Affinity DataEC50:  83nMAssay Description:Partial agonist activity at RXRalpha (unknown origin) expressed in COS1 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50391814(CHEMBL2146901)
Affinity DataEC50:  143nMAssay Description:Partial agonist activity at RXRalpha (unknown origin) expressed in COS1 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50324896(6-[N-Ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-...)
Affinity DataEC50:  3.80nMAssay Description:Partial agonist activity at RXRalpha (unknown origin) expressed in COS1 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Okayama University

Curated by ChEMBL
LigandPNGBDBM50429866(CHEMBL2332887)
Affinity DataEC50:  15nMAssay Description:Partial agonist activity at RXRalpha (unknown origin) expressed in COS1 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 1nMAssay Description:Inhibition of CBP (unknown origin) biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340866(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35751(cis-1,2-diaminocyclohexane derivative, 8h)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340864(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340874(3-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35756(cis-1,2-diaminocyclohexane derivative, 8m)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340872(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50069631(CHEMBL3402520)
Affinity DataIC50: 2.20nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50069632(CHEMBL3402521)
Affinity DataIC50: 2.40nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340868(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340876(1-((4-(5-chloro-1H-indole-2-carboxamido)-3-(5-meth...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Nippon Shinyaku

Curated by ChEMBL
LigandPNGBDBM50178611(3-bromo-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human Lyn kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35759(cis-1,2-diaminocyclohexane derivative, 8p)
Affinity DataIC50: 3.20nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Nippon Shinyaku

Curated by ChEMBL
LigandPNGBDBM50208747((R)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human Lyn kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35753(cis-1,2-diaminocyclohexane derivative, 8j)
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340870(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625745(CHEMBL5410422)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625745(CHEMBL5410422)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625751(CHEMBL5405737)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of wild-type EGFR (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625751(CHEMBL5405737)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50373933(CHEMBL258328)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35754(cis-1,2-diaminocyclohexane derivative, 8k)
Affinity DataIC50: 4.80nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Nippon Shinyaku

Curated by ChEMBL
LigandPNGBDBM50178615(N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human Lyn kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50373927(CHEMBL271011)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Nippon Shinyaku

Curated by ChEMBL
LigandPNGBDBM50178615(N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human Abl kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625748(CHEMBL5415613)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625752(CHEMBL5405222)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340860(methyl 2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50373929(CHEMBL256814)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35755(cis-1,2-diaminocyclohexane derivative, 8l)
Affinity DataIC50: 5.70nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50373931(CHEMBL402343)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625748(CHEMBL5415613)
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35748(cis-1,2-diaminocyclohexane derivative, 8e)
Affinity DataIC50: 6.5nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625752(CHEMBL5405222)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340857(N-(2-(5-chloro-1H-indole-2-carboxamido)phenyl)-5-m...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Nippon Shinyaku

Curated by ChEMBL
LigandPNGBDBM50208748((4-(((S)-3-((dimethylamino)methyl)pyrrolidin-1-yl)...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human Lyn kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50069628(CHEMBL3402517)
Affinity DataIC50: 7.60nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with His-tagged p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50340862(N-(2-(5-chloro-1H-indole-2-carboxamido)-5-(dimethy...)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
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