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TargetMicrotubule-associated protein tau(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384538(CHEMBL2036419 | CHEMBL2036420)
Affinity DataKd:  44.8nMAssay Description:Binding affinity to recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35767(cis-1,2-diaminocyclohexane derivative, 5h)
Affinity DataIC50: 0.430nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35769(cis-1,2-diaminocyclohexane derivative, 5j)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35762(cis-1,2-diaminocyclohexane derivative, 5c)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35765(cis-1,2-diaminocyclohexane derivative, 5f)
Affinity DataIC50: 3.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35773(cis-1,2-diaminocyclohexane derivative, 48)
Affinity DataIC50: 3.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35763(cis-1,2-diaminocyclohexane derivative, 5d)
Affinity DataIC50: 4.10nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373933(CHEMBL258328)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373927(CHEMBL271011)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35770(cis-1,2-diaminocyclohexane derivative, 5k)
Affinity DataIC50: 4.90nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373929(CHEMBL256814)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35760(cis-1,2-diaminocyclohexane derivative, 5a)
Affinity DataIC50: 5.70nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373931(CHEMBL402343)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373928(CHEMBL403904)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50328730(N-((3R,4S)-4-(5-chloro-1H-indole-2-carboxamido)-1-...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50328729(N-((3R,4S)-1-acetyl-4-(5-chloro-1H-indole-2-carbox...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373930(CHEMBL271895)
Affinity DataIC50: 9nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373921(CHEMBL257080)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35772(cis-1,2-diaminocyclohexane derivative, 45c)
Affinity DataIC50: 9.5nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373938(CHEMBL271316)
Affinity DataIC50: 10nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35771(cis-1,2-diaminocyclohexane derivative, 45a)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35768(cis-1,2-diaminocyclohexane derivative, 5i)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50214995(cis-N-(2-(5-chloro-1H-indole-2-carboxamido)cyclohe...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373924(CHEMBL437213)
Affinity DataIC50: 26nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373934(CHEMBL444898)
Affinity DataIC50: 28nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35766(cis-1,2-diaminocyclohexane derivative, 5g)
Affinity DataIC50: 35nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50214983(N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYC...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373922(CHEMBL401661)
Affinity DataIC50: 45nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373926(CHEMBL270797)
Affinity DataIC50: 47nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373935(CHEMBL257903)
Affinity DataIC50: 48nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373925(CHEMBL257284)
Affinity DataIC50: 56nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373936(CHEMBL270391)
Affinity DataIC50: 62nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373932(CHEMBL257268)
Affinity DataIC50: 110nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373937(CHEMBL270604)
Affinity DataIC50: 130nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384538(CHEMBL2036419 | CHEMBL2036420)
Affinity DataIC50: 256nMAssay Description:Displacement of Thioflavin S from recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50373923(CHEMBL401680)
Affinity DataIC50: 530nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35764(cis-1,2-diaminocyclohexane derivative, 5e)
Affinity DataIC50: 870nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35761(cis-1,2-diaminocyclohexane derivative, 5b)
Affinity DataIC50: 4.00E+3nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384537(CHEMBL2036430)
Affinity DataKi:  0.480nMAssay Description:Displacement of Thioflavin S from recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50492522(CHEMBL2407622)
Affinity DataKi:  0.895nMAssay Description:Binding affinity to beta-amyloid plaque in Alzheimer's disease patient brain cortex after 1 hr by thioflavin-S based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50492526(CHEMBL2407616)
Affinity DataKi:  0.895nMAssay Description:Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50122787(4-(6-iodoimidazo[1,2-a]pyridin-2-yl)-N,N-dimethyla...)
Affinity DataKi:  7.20nMAssay Description:Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50492518(Florbetapir | US10906900, AV45)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384538(CHEMBL2036419 | CHEMBL2036420)
Affinity DataKi:  13nMAssay Description:Displacement of Thioflavin S from recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50492519(CHEMBL2407615)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50492516(CHEMBL2407621)
Affinity DataKi:  16nMAssay Description:Binding affinity to beta-amyloid plaque in Alzheimer's disease patient brain cortex after 1 hr by thioflavin-S based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50492523(CHEMBL2407623)
Affinity DataKi:  111nMAssay Description:Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50492523(CHEMBL2407623)
Affinity DataKi:  111nMAssay Description:Binding affinity to beta-amyloid plaque in Alzheimer's disease patient brain cortex after 1 hr by thioflavin-S based autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50492520(CHEMBL2407624)
Affinity DataKi:  242nMAssay Description:Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
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