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TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251556(CHEMBL4082512)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251557(CHEMBL4062422)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251528(CHEMBL4089303)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50427221(5-Aminonicotinic Acid | CHEMBL1491941)
Affinity DataKi:  3.80E+3nMAssay Description:Binding affinity to human recombinant DDOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRCG38204, isoform CRA_d(Rat)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50427221(5-Aminonicotinic Acid | CHEMBL1491941)
Affinity DataKi:  5.89E+3nMAssay Description:Inhibition of rat recombinant DDO using D-AspMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251512(CHEMBL4060321)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251524(CHEMBL4070069)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Mouse)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50427221(5-Aminonicotinic Acid | CHEMBL1491941)
Affinity DataKi:  8.69E+3nMAssay Description:Inhibition of mouse recombinant DDO using D-AspMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251525(CHEMBL4103125)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251526(CHEMBL4060636)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251558(CHEMBL4097681)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50121995(CHEMBL3617316)
Affinity DataKi:  1.51E+4nMAssay Description:Binding affinity to human recombinant DDOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251523(CHEMBL4076133)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251527(CHEMBL4084914)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251530(CHEMBL4073516)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Mouse)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50121995(CHEMBL3617316)
Affinity DataKi:  3.26E+4nMAssay Description:Inhibition of mouse recombinant DDO using D-AspMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251511(CHEMBL4094240)
Affinity DataKi:  4.50E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251560(CHEMBL4065237)
Affinity DataKi:  4.50E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251576(CHEMBL4074962)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251531(CHEMBL4080456)
Affinity DataKi:  5.30E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRCG38204, isoform CRA_d(Rat)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50121995(CHEMBL3617316)
Affinity DataKi:  6.59E+4nMAssay Description:Inhibition of rat recombinant DDO using D-AspMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251529(CHEMBL4067296)
Affinity DataKi:  7.20E+4nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251559(CHEMBL4083188)
Affinity DataKi:  1.47E+5nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM14673(Fragment 3 | Malonic Acid | propanedioic acid)
Affinity DataKi:  1.53E+5nMAssay Description:Binding affinity to human recombinant DDOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50251544(CHEMBL4105019)
Affinity DataKi:  5.83E+5nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Mouse)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM14673(Fragment 3 | Malonic Acid | propanedioic acid)
Affinity DataKi:  1.22E+6nMAssay Description:Inhibition of mouse recombinant DDO using D-AspMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRCG38204, isoform CRA_d(Rat)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM14673(Fragment 3 | Malonic Acid | propanedioic acid)
Affinity DataKi:  1.56E+6nMAssay Description:Inhibition of rat recombinant DDO using D-AspMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
California State University

Curated by ChEMBL
LigandPNGBDBM50127647(CHEMBL296745 | Phosphoric acid diethyl ester pheny...)
Affinity DataKi:  1.59E+6nMAssay Description:Inhibition of horse serum BChE using butyrylthiocholine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269429(CHEMBL4084855)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human GSK-3beta using prephosphorylated-GS1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scintillation spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269428(CHEMBL4063206)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human GSK-3beta using prephosphorylated-GS1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scintillation spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269437(CHEMBL4077376)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human GSK-3beta using prephosphorylated-GS1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scintillation spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandPNGBDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)
Affinity DataIC50:  0.370nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50:  0.390nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269438(CHEMBL4076060)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human GSK-3beta using prephosphorylated-GS1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scintillation spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fer(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50501949(CHEMBL4461851)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269443(CHEMBL4095848)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human GSK-3beta using prephosphorylated-GS1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scintillation spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)
Affinity DataIC50:  0.560nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499813((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...)
Affinity DataIC50:  0.560nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499810(N-((S)-1-((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoy...)
Affinity DataIC50:  0.770nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandPNGBDBM499814((2-chloro-4-phenoxyphenyl)(4- (((3S,6S)-6-(hydroxy...)
Affinity DataIC50:  0.790nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSodium/glucose cotransporter 2(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50438462(CHEMBL2414623)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human SGLT2 expressed in CHOK cells assessed as reduction of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269440(CHEMBL4065818)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human GSK-3beta using prephosphorylated-GS1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scintillation spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50:  0.850nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50:  0.850nMAssay Description:Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499838((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-((R)-1- ...)
Affinity DataIC50:  0.930nMAssay Description:Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499974((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...)
Affinity DataIC50:  0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499924(N-(4-chloro-3-(4-(((3R,6S)-6- (hydroxymethyl)tetra...)
Affinity DataIC50:  0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499869(N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...)
Affinity DataIC50:  0.980nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499976((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...)
Affinity DataIC50:  0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499890((S)-2-hydroxy-N-(cis-4-((5-(4- phenoxybenzoyl)-7H-...)
Affinity DataIC50:  1nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

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