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TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM82247(SCH 23390,R(+) | CAS_87134-87-0 | CHEMBL2158641 | ...)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at dopamine D1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM82247(SCH 23390,R(+) | CAS_87134-87-0 | CHEMBL2158641 | ...)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity at dopamine D5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)TBA
LigandPNGBDBM50056445(lisuride, (S) | lisuride | N'-((8alpha)-9,10-Dideh...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to D2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(2) dopamine receptor(Human)TBA
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to D2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(2) dopamine receptor(Human)TBA
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to D2L receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM82247(SCH 23390,R(+) | CAS_87134-87-0 | CHEMBL2158641 | ...)
Affinity DataIC50: 0.370nMAssay Description:Antagonist activity at human dopamine D1 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetD(1B) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50004822(CHEMBL24077 | SKF 38393 (+) | SK-383933 | R(+)SKF ...)
Affinity DataKi:  0.5nMAssay Description:Agonist activity at dopamine D5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50056445(lisuride, (S) | lisuride | N'-((8alpha)-9,10-Dideh...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to 5HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50336860(N-propyl-2-fluoropropanoxy-11-monohydroxy aporphin...)
Affinity DataKi:  0.540nMAssay Description:Binding affinity to D1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(4) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50487259(CHEBI:64219 | [3H]NEMONAPRIDE)
Affinity DataKi:  0.75nMAssay Description:Displacement of [3H]-methylspiperone from dopamine D4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50001775(cid_5074 | Ritanserine | 6-(2-{4-[Bis-(4-fluoro-ph...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]Mesulergine from 5-HT2C receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM21393(cid_1220 | CHEMBL56 | 7-(dipropylamino)-5,6,7,8-te...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]-WAY100635 from human 5-HT1A receptor expresssed in stable CHO cell membrane incubated for 90 mins by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM21393(cid_1220 | CHEMBL56 | 7-(dipropylamino)-5,6,7,8-te...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.830nMAssay Description:Binding affinity to 5HT2A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50336863((R)-6-ethyl-2-(2-fluoroethoxy)-5,6,6a,7-tetrahydro...)
Affinity DataKi:  0.830nMAssay Description:Binding affinity to D1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50487259(CHEBI:64219 | [3H]NEMONAPRIDE)
Affinity DataKi:  0.860nMAssay Description:Displacement of [3H]-methylspiperone from dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50487259(CHEBI:64219 | [3H]NEMONAPRIDE)
Affinity DataKi:  0.860nMAssay Description:Displacement of [3H]-N-Methylspiperone from human dopamine D4 receptor expressed in stable HEK cells incubated for 90 mins by microbeta counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50004822(CHEMBL24077 | SKF 38393 (+) | SK-383933 | R(+)SKF ...)
Affinity DataKi:  1nMAssay Description:Agonist activity at dopamine D1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50087033((1R,5aR)-1-methoxy-1,6-dimethyl-1,5,5a,6,7,8-hexah...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50004823(CHEMBL298406 | Ecopipam | SCH 39166 | (6aS,13bR)-1...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to D1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50570808(CHEMBL4846574)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-methylspiperone from dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50487259(CHEBI:64219 | [3H]NEMONAPRIDE)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-N-Methylspiperone from dopamine D3 receptor (unknown origin) incubated for 90 mins by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)TBA
LigandPNGBDBM50017655(2-{4-[3-(2-Trifluoromethyl-phenothiazin-10-yl)-pro...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to D2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50004823(CHEMBL298406 | Ecopipam | SCH 39166 | (6aS,13bR)-1...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)TBA
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to D2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50056445(lisuride, (S) | lisuride | N'-((8alpha)-9,10-Dideh...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to D3 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(1B) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50056445(lisuride, (S) | lisuride | N'-((8alpha)-9,10-Dideh...)
Affinity DataKi:  2nMAssay Description:Binding affinity to alpha2A adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50570806(CHEMBL4876260)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-methylspiperone from dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)TBA
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to human D5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]SCH-23390 from human dopamine D1 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)TBA
LigandPNGBDBM50487259(CHEBI:64219 | [3H]NEMONAPRIDE)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]N-methylspiperone from dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human dopamine D1 receptor expressed in HEK-T cells assessed as cAMP production incubated for 15 mins by luciferase based Glosens...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to alpha2C adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50366495(CHEMBL1255588 | (+)butaclamol)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  3nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-Ketanserin from 5-HT2A receptor (unknown origin) incubated for 90 mins by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50002316(LARODOPA | SINEMET | 4-(2-Amino-ethyl)-benzene-1,2...)
Affinity DataKi:  3nMAssay Description:Binding affinity to D3 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(4) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50056445(lisuride, (S) | lisuride | N'-((8alpha)-9,10-Dideh...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to D4 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50017655(2-{4-[3-(2-Trifluoromethyl-phenothiazin-10-yl)-pro...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to D3 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50570809(CHEMBL4878587)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]-methylspiperone from dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50599264(CHEMBL5204813)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]Mesulergine from 5-HT2C receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-LSD from human 5-HT6 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
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