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Report error Found 150 with Last Name = 'napoletano' and Initial = 'm'
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286589((S)-5-{(S)-2-[Bis-((R)-sec-butyl)-amino]-1-hydroxy...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human VCAM and Ramos cell VLA-4 interactionMore data for this Ligand-Target Pair
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human VCAM and Ramos cell VLA-4 interactionMore data for this Ligand-Target Pair
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenateMore data for this Ligand-Target Pair
LigandPNGBDBM50219407(CHEMBL84350)
Affinity DataKi:  5nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218261(CHEMBL74631)
Affinity DataKi:  13nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  15nMAssay Description:Inhibition of [3H]-[D-Pen2, D-Pen5]-enkephalin (2 nM) to Opioid receptor delta 1 of male Sprague-Dawley rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50218265(CHEMBL308407)
Affinity DataKi:  16nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218578(CHEMBL79902)
Affinity DataKi:  17nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  27nMAssay Description:Inhibition of 9 (2nM) binding to Opioid receptor kappa 1 of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286584((S)-5-{(S)-2-[((R)-sec-Butyl)-((S)-sec-butyl)-amin...)
Affinity DataKi:  32nMAssay Description:Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50218586(CHEMBL79471)
Affinity DataKi:  34nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286586((R)-5-{(R)-2-[Bis-((R)-sec-butyl)-amino]-1-hydroxy...)
Affinity DataKi:  35nMAssay Description:Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataKi:  38nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataKi:  38nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
LigandPNGBDBM50218262(CHEMBL308158)
Affinity DataKi:  46nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50219414(CHEMBL79661)
Affinity DataKi:  60nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286589((S)-5-{(S)-2-[Bis-((R)-sec-butyl)-amino]-1-hydroxy...)
Affinity DataKi:  63nMAssay Description:Inhibition of 9 (2nM) binding to Opioid receptor kappa 1 of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50219411(CHEMBL82934)
Affinity DataKi:  63nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218267(CHEMBL74404)
Affinity DataKi:  71nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286587((R)-5-{(R)-2-[((R)-sec-Butyl)-((S)-sec-butyl)-amin...)
Affinity DataKi:  87nMAssay Description:Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50218589(CHEMBL79535)
Affinity DataKi:  89nMAssay Description:Inhibition of alpha4-beta1 VCAM binding in Jurkat cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50092350((5-Cyclopentyloxy-6-methoxy-phthalazin-1-yl)-(3,5-...)
Affinity DataKi:  95nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286580((R)-5-{(S)-2-[Bis-((R)-sec-butyl)-amino]-1-hydroxy...)
Affinity DataKi:  100nMAssay Description:Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50218264(CHEMBL72362)
Affinity DataKi:  121nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50219417(CHEMBL421343)
Affinity DataKi:  128nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50219409(CHEMBL354743)
Affinity DataKi:  138nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286585((S)-5-{(R)-2-[Bis-((S)-sec-butyl)-amino]-1-hydroxy...)
Affinity DataKi:  145nMAssay Description:Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50218260(CHEMBL70391)
Affinity DataKi:  149nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218260(CHEMBL70391)
Affinity DataKi:  149nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218260(CHEMBL70391)
Affinity DataKi:  149nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218268(CHEMBL309341)
Affinity DataKi:  164nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286591((R)-5-{(S)-2-[((R)-sec-Butyl)-((S)-sec-butyl)-amin...)
Affinity DataKi:  198nMAssay Description:Inhibition of 9 (2nM) binding to Opioid receptor kappa 1 of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50219404(CHEMBL79739)
Affinity DataKi:  199nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218588(CHEMBL312375)
Affinity DataKi:  204nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50219406(CHEMBL309420)
Affinity DataKi:  208nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50219413(CHEMBL81226)
Affinity DataKi:  212nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50219405(CHEMBL81020)
Affinity DataKi:  235nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50219410(CHEMBL311025)
Affinity DataKi:  237nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286587((R)-5-{(R)-2-[((R)-sec-Butyl)-((S)-sec-butyl)-amin...)
Affinity DataKi:  260nMAssay Description:Inhibition of 9 (2nM) binding to Opioid receptor kappa 1 of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286589((S)-5-{(S)-2-[Bis-((R)-sec-butyl)-amino]-1-hydroxy...)
Affinity DataKi:  265nMAssay Description:Inhibition of [3H]-[D-Pen2, D-Pen5]-enkephalin (2 nM) to Opioid receptor delta 1 of male Sprague-Dawley rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286583((R)-5-{(S)-2-[Bis-((S)-sec-butyl)-amino]-1-hydroxy...)
Affinity DataKi:  270nMAssay Description:Inhibition of 9 (2nM) binding to Opioid receptor kappa 1 of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50218580(CHEMBL310387)
Affinity DataKi:  271nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218269(CHEMBL73640)
Affinity DataKi:  286nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50218263(CHEMBL419814)
Affinity DataKi:  320nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286588((S)-5-{(R)-2-[((R)-sec-Butyl)-((S)-sec-butyl)-amin...)
Affinity DataKi:  340nMAssay Description:Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
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