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Target5-hydroxytryptamine receptor 3A(Human)
The University of Louisiana At Monroe

Curated by ChEMBL
LigandPNGBDBM50103074(1-Allyl-2-piperazin-1-yl-1H-benzoimidazole | CHEMB...)
Affinity DataEC50:  240nMAssay Description:Binding affinity against human 5-hydroxytryptamine 3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616146(CHEMBL5411016)
Affinity DataKd:  530nMAssay Description:Binding affinity to C-terminal biotin-tagged YEATS4 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616147(CHEMBL5434894)
Affinity DataKd:  297nMAssay Description:Binding affinity to C-terminal biotin-tagged YEATS4 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616151(CHEMBL5397585)
Affinity DataKd:  103nMAssay Description:Binding affinity to C-terminal biotin-tagged YEATS4 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616142(CHEMBL5428051)
Affinity DataKd:  340nMAssay Description:Binding affinity to C-terminal biotin-tagged YEATS4 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616146(CHEMBL5411016)
Affinity DataKd:  80nMAssay Description:Binding affinity to YEATS4 (unknown origin) assessed as dissociation constant by isothermal calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616147(CHEMBL5434894)
Affinity DataKd:  45nMAssay Description:Binding affinity to YEATS4 (unknown origin) assessed as dissociation constant by isothermal calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616151(CHEMBL5397585)
Affinity DataKd:  53nMAssay Description:Binding affinity to YEATS4 (unknown origin) assessed as dissociation constant by isothermal calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616142(CHEMBL5428051)
Affinity DataKd:  53nMAssay Description:Binding affinity to YEATS4 (unknown origin) assessed as dissociation constant by isothermal calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616152(CHEMBL5439842)
Affinity DataKd:  30nMAssay Description:Binding affinity to YEATS4 (unknown origin) assessed as dissociation constant by isothermal calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein ENL(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50625619(CHEMBL4752253)
Affinity DataKd:  110nMAssay Description:Binding affinity to MLLT1 YD domain (unknown origin) assessed as dissociation constant by biolayer interferometry assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetProtein AF-9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50625619(CHEMBL4752253)
Affinity DataKd:  110nMAssay Description:Binding affinity to MLLT3 YD domain (unknown origin) assessed as dissociation constant by biolayer interferometry assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetProtein ENL(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50625619(CHEMBL4752253)
Affinity DataKd:  82nMAssay Description:Binding affinity to MLLT1 YD domain (unknown origin) assessed as dissociation constant by isothermal calorimetry assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetProtein AF-9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50625619(CHEMBL4752253)
Affinity DataKd:  76nMAssay Description:Binding affinity to MLLT3 YD domain (unknown origin) assessed as dissociation constant by isothermal calorimetry assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Mouse)
Virtua Drug

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  3.40E+3nMAssay Description:Agonist activity at wild type mouse 5HT3A receptor expressed in Xenopus oocyte by two-electrode voltage patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Mouse)
Virtua Drug

Curated by ChEMBL
LigandPNGBDBM50053615(m-chlorophenylbiguanidine | 3-Chloro-Phenyl biguan...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at wild type mouse 5HT3A receptor expressed in Xenopus oocyte by two-electrode voltage patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232526(5-((2,4-difluorophenoxy)methyl)quinazoline-2,4-dia...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232538(D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)pip...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237216(CHEMBL4080254)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237201(CHEMBL4082618)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237200(CHEMBL4072132)
Affinity DataIC50: 0.0690nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM36530(D157493)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237203(CHEMBL250072)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237199(CHEMBL4077061)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237205(CHEMBL398675)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237209(CHEMBL4062544)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237211(CHEMBL4061457)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237210(CHEMBL399673)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM36534(D156095)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237217(CHEMBL342595)
Affinity DataIC50: 1nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237202(CHEMBL4103454)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237198(CHEMBL4068466)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237218(CHEMBL4072481)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232566(5-(3-chlorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237204(CHEMBL343543)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237206(CHEMBL4075292)
Affinity DataIC50: 11nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237212(CHEMBL4100442)
Affinity DataIC50: 12nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237214(CHEMBL4084161)
Affinity DataIC50: 14nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237208(CHEMBL4090641)
Affinity DataIC50: 16nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50398093(CHEMBL2182046 | US9321738, 6)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50398094(CHEMBL2182044 | US9321738, 11)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50398095(CHEMBL2182043 | US9321738, 2)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50398091(CHEMBL2182049 | US9321738, 12)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50398101(CHEMBL2182063)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50398094(CHEMBL2182044 | US9321738, 11)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50398095(CHEMBL2182043 | US9321738, 2)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at LPA1 in human lung fibroblasts assessed as inhibition of LPA-induced contraction after 18 hrs by 3D collagen gel contraction a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50398101(CHEMBL2182063)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50398115(CHEMBL2182038)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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