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Target72 kDa type IV collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50240611((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  0.300nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM30344(Cipemastat | Trocade)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183783((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  0.700nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM30344(Cipemastat | Trocade)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064310(2-Ethoxy-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d...)
Affinity DataKi:  1.40nM Kon:  0.000127M-1s-1 Koff:  9.36E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064318(2-Propoxy-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-...)
Affinity DataKi:  1.43nM Kon:  0.000142M-1s-1 Koff:  9.93E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50240611((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  2nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataKi:  2nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064316(2-Ethylsulfanyl-5,6-dimethyl-thieno[2,3-d][1,3]oxa...)
Affinity DataKi:  2.73nM Kon:  0.00358M-1s-1 Koff:  1.31E+6s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183783((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  3nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  3.5nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50240611((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  3.80nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064314(5,6-Dimethyl-2-propoxy-thieno[2,3-d][1,3]oxazin-4-...)
Affinity DataKi:  4.02nM Kon:  0.0000628M-1s-1 Koff:  1.56E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  4.80nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  4.90nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataKi:  5nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataKi:  5nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064325(2-Ethoxy-5-isopropyl-thieno[2,3-d][1,3]oxazin-4-on...)
Affinity DataKi:  5.61nM Kon:  0.000429M-1s-1 Koff:  7.64E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064320(2-Ethylsulfanyl-5,6,7,8-tetrahydro-benzo[4,5]thien...)
Affinity DataKi:  5.70nMAssay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064326(2-Methylsulfanyl-5,6,7,8-tetrahydro-benzo[4,5]thie...)
Affinity DataKi:  5.74nM Kon:  0.00156M-1s-1 Koff:  2.72E+5s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50084235(2-Diethylamino-benzo[4,5]thieno[2,3-d][1,3]oxazin-...)
Affinity DataKi:  5.80nMAssay Description:Inhibitory activity of the compound was tested against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  6.30nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183785((S)-1-((2S,3S)-3-(hydroxycarbamoyl)-2-(4-methoxyph...)
Affinity DataKi:  7nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183787((S)-1-((2S,3R)-4-(hydroxyamino)-3-(hydroxymethyl)-...)
Affinity DataKi:  8nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183785((S)-1-((2S,3S)-3-(hydroxycarbamoyl)-2-(4-methoxyph...)
Affinity DataKi:  8nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  8.90nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  9.80nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183787((S)-1-((2S,3R)-4-(hydroxyamino)-3-(hydroxymethyl)-...)
Affinity DataKi:  10nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064313(2-Ethoxy-5,6-dimethyl-thieno[2,3-d][1,3]oxazin-4-o...)
Affinity DataKi:  10.7nM Kon:  0.000130M-1s-1 Koff:  1.22E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183785((S)-1-((2S,3S)-3-(hydroxycarbamoyl)-2-(4-methoxyph...)
Affinity DataKi:  11nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183783((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  12nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  13nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  13nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50084232(2-(diethylamino)-5-isopropyl-4H-thieno[2,3-d][1,3]...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity of the compound was tested against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50084233(2-Diethylamino-6,7-dihydro-5H-cyclopenta[4,5]thien...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity of the compound was tested against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064308(2-Diethylamino-5,6,7,8-tetrahydro-benzo[4,5]thieno...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity of the compound was tested against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50240611((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  15nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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