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LigandPNGBDBM50287290(KRH-594 | CHEMBL34866 | Potassium; 2-[5-ethyl-3-[2...)
Affinity DataIC50: 0.440nMAssay Description:In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50287294(2-[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylm...)
Affinity DataIC50: 0.440nMAssay Description:In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50287291(N-[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylm...)
Affinity DataIC50: 0.660nMAssay Description:In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article

TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107587(CHEMBL3601910)
Affinity DataIC50: 2.40nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50287289(2-Chloro-N-[5-ethyl-3-[2'-(1H-tetrazol-5-yl)-biphe...)
Affinity DataIC50: 3.60nMAssay Description:In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50287292(Cyclopropanecarboxylic acid [5-ethyl-3-[2'-(1H-tet...)
Affinity DataIC50: 6.5nMAssay Description:In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50287295(N-[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylm...)
Affinity DataIC50: 7.20nMAssay Description:In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article

TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107535(CHEMBL3601902)
Affinity DataIC50: 7.5nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107532(CHEMBL3601900)
Affinity DataIC50: 8.20nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107588(CHEMBL3601911)
Affinity DataIC50: 8.80nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107539(CHEMBL3601906)
Affinity DataIC50: 9.30nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107538(CHEMBL3601905)
Affinity DataIC50: 9.70nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50406795(Cozaar | LOSARTAN POTASSIUM)
Affinity DataIC50: 9.80nMAssay Description:In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article

TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107424(CHEMBL3600421)
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107428(CHEMBL3600426)
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107429(CHEMBL3600427)
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023929(CHEMBL3325502)
Affinity DataIC50: 15nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107452(CHEMBL3601898)
Affinity DataIC50: 15nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107585(CHEMBL3601908)
Affinity DataIC50: 17nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNicotinic acetylcholine receptor alpha 5 subunit(House fly)
Gifu University

Curated by ChEMBL
LigandPNGBDBM50212288((2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimida...)
Affinity DataIC50: 20nMAssay Description:Displacement of [3HIMI from nicotinic acetylcholine receptor in Musca domestica (house fly) head membranes incubated for 60 min by liquid scintillati...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107426(CHEMBL3600424)
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107422(CHEMBL3601915)
Affinity DataIC50: 28nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107435(CHEMBL3600433)
Affinity DataIC50: 29nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107423(CHEMBL3600420)
Affinity DataIC50: 31nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107534(CHEMBL3601901)
Affinity DataIC50: 31nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107537(CHEMBL3601904)
Affinity DataIC50: 31nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 32nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50287293(N-[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylm...)
Affinity DataIC50: 37nMAssay Description:In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article

TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107586(CHEMBL3601909)
Affinity DataIC50: 38nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107425(CHEMBL3600423)
Affinity DataIC50: 42nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107431(CHEMBL3600430)
Affinity DataIC50: 44nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023797(CHEMBL3325511)
Affinity DataIC50: 52nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107395(CHEMBL3601912)
Affinity DataIC50: 56nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107421(CHEMBL3601913)
Affinity DataIC50: 56nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107430(CHEMBL3600429)
Affinity DataIC50: 60nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023926(CHEMBL3325505)
Affinity DataIC50: 62nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023866(CHEMBL3325509)
Affinity DataIC50: 66nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023928(CHEMBL3325503)
Affinity DataIC50: 71nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107427(CHEMBL3600425)
Affinity DataIC50: 71nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50476423(CHEMBL228435)
Affinity DataIC50: 72nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50476427(CHEMBL228436)
Affinity DataIC50: 78nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023930(CHEMBL3325501)
Affinity DataIC50: 80nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50476433(CHEMBL228486)
Affinity DataIC50: 83nMAssay Description:Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023874(CHEMBL3325508)
Affinity DataIC50: 99nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023924(CHEMBL3325507)
Affinity DataIC50: 105nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023925(CHEMBL3325506)
Affinity DataIC50: 107nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50476427(CHEMBL228436)
Affinity DataIC50: 108nMAssay Description:Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50476432(CHEMBL228437)
Affinity DataIC50: 108nMAssay Description:Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50476430(CHEMBL388315)
Affinity DataIC50: 111nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50023993(CHEMBL3325495)
Affinity DataIC50: 112nMAssay Description:Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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