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TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581660(CHEMBL1714813)
Affinity DataKd:  301nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581661(CHEMBL5084899)
Affinity DataKd:  937nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581662(CHEMBL4172691)
Affinity DataKd:  1.93E+4nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581663(CHEMBL5087955 | US20240083857, Example 206)
Affinity DataKd:  469nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581664(CHEMBL5085531)
Affinity DataKd:  16nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581665(CHEMBL5084571)
Affinity DataKd:  104nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581666(CHEMBL5087341)
Affinity DataKd:  123nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581667(CHEMBL5088924)
Affinity DataKd:  16nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581668(CHEMBL5084055)
Affinity DataKd:  350nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581669(CHEMBL5092944)
Affinity DataKd:  751nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581670(CHEMBL5093215)
Affinity DataKd:  1.49E+3nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581671(CHEMBL5087825)
Affinity DataKd:  24nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataKd:  3nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087814(CHEMBL3426791)
Affinity DataEC50:  4.00E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087815(CHEMBL3426792)
Affinity DataEC50:  5.00E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087816(CHEMBL3426793)
Affinity DataEC50:  7.00E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087817(CHEMBL3426794)
Affinity DataEC50:  2.00E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087818(CHEMBL3426795)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087819(CHEMBL3426796)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087820(CHEMBL3426797)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087821(CHEMBL3426798)
Affinity DataEC50:  3.00E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087822(CHEMBL3426799)
Affinity DataEC50:  2.00E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087824(CHEMBL3426800)
Affinity DataEC50:  5.00E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087825(CHEMBL3426790)
Affinity DataEC50:  3.00E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087826(CHEMBL3426789)
Affinity DataEC50:  2.60E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087835(CHEMBL3426788)
Affinity DataEC50:  6.00E+3nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087838(CHEMBL3426802)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087839(CHEMBL3426801)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087824(CHEMBL3426800)
Affinity DataEC50:  900nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087822(CHEMBL3426799)
Affinity DataEC50:  300nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087821(CHEMBL3426798)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087820(CHEMBL3426797)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087819(CHEMBL3426796)
Affinity DataEC50:  100nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087818(CHEMBL3426795)
Affinity DataEC50:  300nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087817(CHEMBL3426794)
Affinity DataEC50:  100nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087816(CHEMBL3426793)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087815(CHEMBL3426792)
Affinity DataEC50:  100nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087814(CHEMBL3426791)
Affinity DataEC50:  300nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087825(CHEMBL3426790)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087826(CHEMBL3426789)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087835(CHEMBL3426788)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human delta opioid receptor-1 expressed in CHO cells assessed as potentiation of leu-enkephalin-induced response af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087838(CHEMBL3426802)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50087839(CHEMBL3426801)
Affinity DataEC50:  1.00E+4nMAssay Description:Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells assessed as potentiation of endomorphin 1-induced response after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50581660(CHEMBL1714813)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM170441(US9085531, 2)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50054533(CHEMBL3323173)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM170440(US9085531, 40)
Affinity DataIC50: 1.70nMAssay Description:Displacement of [125I]-RTI-55 from recombinant SERT (unknown origin) expressed in HEK cells by saturation binding analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM170444(US9085531, 14)
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCapsid scaffolding protein(HHV-5)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50143640(4-({5-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-napht...)
Affinity DataIC50: 2.70nMAssay Description:Inhibitory concentration against HCMV protease.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCapsid scaffolding protein(HHV-5)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50143634(4-{[5-(4-Bromo-phenoxymethyl)-naphthalen-2-ylamino...)
Affinity DataIC50: 2.80nMAssay Description:Inhibitory concentration against HCMV protease.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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