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TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362835(CHEMBL1940400)
Affinity DataKi:  2.60nMAssay Description:Competitive inhibition at human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as inhibition of NADP+ lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member C3(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50384947(CHEMBL521703)
Affinity DataKi:  6.90nMAssay Description:Inhibition of human GST-tagged 17betaHSD5 expressed in Escherichia coli by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetAldo-keto reductase family 1 member C3(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM35905(Tolfenamic acid | cid_610479 | flufenamic acid ana...)
Affinity DataKi:  8nMAssay Description:Inhibition of human AKR1C3 using S-(+)-1,2,3,4-tetrahydro-1-naphthol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029207((E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethy...)
Affinity DataKi:  46nMAssay Description:Mixed-type inhibition at human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as inhibition of NADP+ link...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetAldo-keto reductase family 1 member C3(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50384946(CHEMBL511708)
Affinity DataKi:  56nMAssay Description:Noncompetitive inhibition of human recombinant AKR1C3 expressed in Escherichia coli JM109 cells using S-tetralol as substrate by fluorometry in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member C3(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50384946(CHEMBL511708)
Affinity DataKi:  56nMAssay Description:Competitive inhibition of human recombinant AKR1C3 expressed in Escherichia coli JM109 cells using NADP+ linked S-tetralol as substrate by fluorometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member C3(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50384946(CHEMBL511708)
Affinity DataKi:  56nMAssay Description:Competitive inhibition of human recombinant AKR1C3 expressed in Escherichia coli JM109 cells using S-tetralol as substrate by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090488(1-Benzyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  640nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D2 by displacing the radioligand [3H]-YM-09151-2 (0.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member C3(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362836(ARTEPILLIN)
Affinity DataKi:  680nMAssay Description:Competitive inhibition of human recombinant AKR1C3 expressed in Escherichia coli JM109 cells using S-tetralol as substrate by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member C3(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362836(ARTEPILLIN)
Affinity DataKi:  680nMAssay Description:Noncompetitive inhibition of human recombinant AKR1C3 expressed in Escherichia coli JM109 cells using S-tetralol as substrate by fluorometry in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50017041((RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline | 1,2...)
Affinity DataKi:  3.57E+3nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D2 by displacing the radioligand [3H]-YM-09151-2 (0.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090489(4-(1,2,3,4-Tetrahydro-isoquinolin-1-ylmethyl)-benz...)
Affinity DataKi:  8.79E+3nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D2 by displacing the radioligand [3H]-YM-09151-2 (0.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(1A) dopamine receptor(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090488(1-Benzyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  9.27E+3nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]-SCH-23,390 (1.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent dopamine transporter(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090489(4-(1,2,3,4-Tetrahydro-isoquinolin-1-ylmethyl)-benz...)
Affinity DataKi:  2.15E+4nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine transporter by displacing the radioligand [3H]-GBR-12,935 (1.0 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent dopamine transporter(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50017041((RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline | 1,2...)
Affinity DataKi:  3.66E+4nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine transporter by displacing the radioligand [3H]-GBR-12,935 (1.0 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent dopamine transporter(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090488(1-Benzyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  5.76E+4nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine transporter by displacing the radioligand [3H]-GBR-12,935 (1.0 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(1A) dopamine receptor(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090489(4-(1,2,3,4-Tetrahydro-isoquinolin-1-ylmethyl)-benz...)
Affinity DataKi:  1.75E+5nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]-SCH-23,390 (1.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(1A) dopamine receptor(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50017041((RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline | 1,2...)
Affinity DataKi:  2.49E+5nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]-SCH-23,390 (1.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046030(CHEMBL3310126)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046053(CHEMBL3310146)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046056(CHEMBL3310149)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046057(CHEMBL3310276)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046036(CHEMBL3310130)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362835(CHEMBL1940400)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046048(CHEMBL3310141)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046050(CHEMBL3310143)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362841(CHEMBL1940399)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046052(CHEMBL3310145)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046049(CHEMBL3310142)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362844(CHEMBL1940396)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362846(CHEMBL1940394)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362843(CHEMBL1940397)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362842(CHEMBL1940398)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046033(CHEMBL3310128)
Affinity DataIC50:  17nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362845(CHEMBL1940395)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362847(CHEMBL1940393)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046042(CHEMBL3310136)
Affinity DataIC50:  23nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362840(CHEMBL1940401)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046041(CHEMBL3310135)
Affinity DataIC50:  23nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046047(CHEMBL3310140)
Affinity DataIC50:  33nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046046(CHEMBL3310139)
Affinity DataIC50:  46nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM19429(4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine | S...)
Affinity DataIC50:  67nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetAndrogen receptor(Human)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM35909(2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-ph...)
Affinity DataIC50:  67nMAssay Description:Antagonist activity at human androgen receptor expressed in mouse NIH3T3 cells assessed as inhibition of DHT-induced transcriptional activation after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362851(CHEMBL1940390)
Affinity DataIC50:  69nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046034(CHEMBL3310129)
Affinity DataIC50:  70nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362838(CHEMBL249448)
Affinity DataIC50:  78nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B1 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B10(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50029207((E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethy...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetAldo-keto reductase family 1 member B1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50362839(CHEMBL249447)
Affinity DataIC50:  88nMAssay Description:Inhibition of human recombinant N-terminus His6-tagged AKR1B1 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046032(CHEMBL3310127)
Affinity DataIC50:  97nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Aska Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50046037(CHEMBL3310131)
Affinity DataIC50:  105nMAssay Description:Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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