Compile Data Set for Download or QSAR
Found 524 with Last Name = 'olivier' and Initial = 'a'
LigandPNGBDBM26263(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Affinity DataKi:  0.810nMMore data for this Ligand-Target Pair
LigandPNGBDBM26263(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Affinity DataKi:  1.39nMMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Synthélabo

Curated by PDSP Ki Database
LigandPNGBDBM26263(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Affinity DataKi:  1.52nMMore data for this Ligand-Target Pair
LigandPNGBDBM26263(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Affinity DataKi:  1.52nMMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50236369((R)-1-morpholino-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26263(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Affinity DataKi:  1.79nMMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50236369((R)-1-morpholino-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of erbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Synthélabo

Curated by PDSP Ki Database
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataKi:  29.6nMMore data for this Ligand-Target Pair
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataKi:  105nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50026756(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Affinity DataKi:  127nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50026756(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Affinity DataKi:  157nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50026756(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Affinity DataKi:  333nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50026756(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Affinity DataKi:  447nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataKi:  829nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis Ltd.

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataKi:  1.61E+3nMAssay Description:Inhibition of human SSAO/VAP1 measuring H2O2 production by Kitz and Wilson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis Ltd.

Curated by ChEMBL
LigandPNGBDBM50384084(CHEMBL2029546)
Affinity DataKi:  1.64E+3nMAssay Description:Inhibition of human SSAO/VAP1 measuring H2O2 production by Kitz and Wilson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataKi:  3.82E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50329079(CHEMBL1270280 | N2-(2,6-dimorpholinopyridin-4-yl)-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  1.10nMAssay Description:In vitro functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETB receptors)More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  1.10nMAssay Description:Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEphrin type-B receptor 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50371358(CHEMBL257478)
Affinity DataIC50:  2nMAssay Description:Inhibition of ebrB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50329080(CHEMBL1270378 | N2-(2,6-dimorpholinopyrimidin-4-yl...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12255(AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro...)
Affinity DataIC50:  2.70nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  2.70nMAssay Description:Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovir...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12241(AZD0530 analogue 19 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50:  3nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50179758(CHEMBL203725 | N-(3-chloro-4-fluorophenyl)-5-(1-me...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12231(AZD0530 analogue 9 | N-(2-chloro-5-methoxyphenyl)-...)
Affinity DataIC50: <4nMpH: 7.4 T: 2°CAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12237(AZD0530 analogue 15 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50: <4nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12243(AZD0530 analogue 21 | N-(2-chloro-5-methoxyphenyl)...)
Affinity DataIC50: <4nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50293247(CHEMBL468970 | N4-(5-chlorobenzo[d][1,3]dioxol-4-y...)
Affinity DataIC50:  4nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12250(AZD0530 analogue 28 | N-(5-Chloro-1,3-benzodioxol-...)
Affinity DataIC50:  4nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12252(AZD0530 analogue 30 | N-(5-Chloro-1,3-benzodioxol-...)
Affinity DataIC50: <4nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12247(AZD0530 analogue 25 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50: <4nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of [3H]-Flumazenil binding to recombinant GABA-A receptor alpha-5 subunit in spinal cordMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12253(AZD0530 analogue 31 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50:  5nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM6218(AZD0530 analogue 34 | Chlorobenzodioxole deriv. 27...)
Affinity DataIC50:  5nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12259(AZD0530 analogue 37 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50:  5nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50329079(CHEMBL1270280 | N2-(2,6-dimorpholinopyridin-4-yl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50171250(CHEMBL197640 | [3-Chloro-4-(3-fluoro-benzyloxy)-ph...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against EGFR kinase phosphorylation using synthetic peptide as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM50174932(CHEMBL197287 | N-(2-chloro-5-methoxypyridin-3-yl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against c-Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50171256(CHEMBL444619 | [3-Chloro-4-(pyridin-2-ylmethoxy)-p...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against erbB2 kinase phosphorylation using synthetic peptide as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50171256(CHEMBL444619 | [3-Chloro-4-(pyridin-2-ylmethoxy)-p...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against EGFR kinase phosphorylation using synthetic peptide as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM50174939(CHEMBL424664 | N-(3-chloro-6-methoxypyridin-2-yl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against c-Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12238(AZD0530 analogue 16 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50:  6nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM50174934(CHEMBL424839 | N-(3-chloro-6-methoxypyridin-2-yl)-...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against c-Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50236375((S)-2-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human erbB2 autophosphorylation in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12240(AZD0530 analogue 18 | N-(5-Chloro-1,3-benzodioxol-...)
Affinity DataIC50:  6nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM12251(AZD0530 analogue 29 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50:  7nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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