Compile Data Set for Download or QSAR
Found 889 with Last Name = 'orita' and Initial = 'm'
TargetVasopressin V2 receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35666(BMC173130 Compound 1t | benzazepinelidene acetamid...)
Affinity DataKi:  9.70nM ΔG°:  -45.4kJ/molepH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35669(benzazepinelidene acetamide derivative, 1d)
Affinity DataKi:  13nM ΔG°:  -44.7kJ/molepH: 7.4 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35669(benzazepinelidene acetamide derivative, 1d)
Affinity DataKi:  13nM ΔG°:  -44.7kJ/molepH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35672(benzazepinelidene acetamide derivative, 1g)
Affinity DataKi:  14nM ΔG°:  -44.5kJ/molepH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35671(benzazepinelidene acetamide derivative, 1f)
Affinity DataKi:  14nM ΔG°:  -44.5kJ/molepH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35670(benzazepinelidene acetamide derivative, 1e)
Affinity DataKi:  16nM ΔG°:  -44.2kJ/molepH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35671(benzazepinelidene acetamide derivative, 1f)
Affinity DataKi:  17nM ΔG°:  -44.0kJ/molepH: 7.4 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35666(BMC173130 Compound 1t | benzazepinelidene acetamid...)
Affinity DataKi:  28nM ΔG°:  -42.8kJ/molepH: 7.4 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  38nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35670(benzazepinelidene acetamide derivative, 1e)
Affinity DataKi:  39nM ΔG°:  -42.0kJ/molepH: 7.4 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35672(benzazepinelidene acetamide derivative, 1g)
Affinity DataKi:  43nM ΔG°:  -41.8kJ/molepH: 7.4 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35668(benzazepinelidene acetamide derivative, 1c)
Affinity DataKi:  78nM ΔG°:  -40.3kJ/molepH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Astellas Pharma Inc

LigandPNGBDBM35668(benzazepinelidene acetamide derivative, 1c)
Affinity DataKi:  170nM ΔG°:  -38.4kJ/molepH: 7.4 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096004(7-Hydroxy-3-[4-(2-oxo-2H-chromen-3-yl)-thiazol-2-y...)
Affinity DataKi:  280nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096003(7-Hydroxy-3-phenyl-chromen-2-one | 7-hydroxy-3-phe...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096001(7-Hydroxy-3-pyrazolo[1,5-a]pyridin-2-yl-chromen-2-...)
Affinity DataKi:  500nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50095993(7-Hydroxy-2-oxo-2H-chromene-3-carbothioic acid ami...)
Affinity DataKi:  550nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096002(3-(4-Benzo[1,3]dioxol-5-yl-thiazol-2-yl)-7-hydroxy...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096007(2-Oxo-2H-chromene-3-carboxylic acid 2-oxo-2-phenyl...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096006(7-Hydroxy-3-(2-methyl-thiazol-4-yl)-chromen-2-one ...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096000(3-(2-Fluoro-4-hydroxy-phenyl)-acrylic acid anion)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50095994(3-Cyano-7-hydroxycoumarin (2) | 7-Hydroxy-2-oxo-2H...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096005(7-Hydroxy-3-(4-methyl-thiazol-2-yl)-chromen-2-one ...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096008(3-Acetyl-7-hydroxy-chromen-2-one | 3-acetyl-7-hydr...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50095996(3-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-3-oxo-propioni...)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50096009(3-(4-Dimethylamino-benzylidene)-chroman-2,4-dione ...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical Company, Ltd

Curated by ChEMBL
LigandPNGBDBM50095995(7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL E...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521995(CHEMBL4578182)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50304425(2-(4-morpholinophenylamino)-4-(2,3,6-trifluorobenz...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50243934(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,6-triflu...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50522021(CHEMBL4465116)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521996(CHEMBL4459940)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521996(CHEMBL4459940)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50521995(CHEMBL4578182)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50244291(4-[(2-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50431067(CHEMBL2338797 | US10202399, Example 18 | US1046366...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50260725(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50431083(CHEMBL2338803 | US10202399, Example 24 | US1046366...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50243884(4-[(2,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50244292(4-[(3-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50243933(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,5-triflu...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50522014(CHEMBL4460657)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50304429(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Mus musculus)
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50431067(CHEMBL2338797 | US10202399, Example 18 | US1046366...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Mus musculus)
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50431074(CHEMBL2338790 | US10463663, Example 27 | US1112982...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50431069(CHEMBL2338795 | US10202399, Example 27 | US1046366...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM50520336(CHEMBL4470042)
Affinity DataIC50:  2nMAssay Description:Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50431065(CHEMBL2338799 | US10202399, Example 16)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50243882(4-[(2,3-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 6(Homo sapiens (Human))
Astellas Pharma Inc

Curated by ChEMBL
LigandPNGBDBM50243885(4-[(2,6-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of STAT6 activation (unknown origin) in FW4 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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