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TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176475(((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataEC50:  3.20E+3nMAssay Description:Reduction of viral RNA and protein in Huh7 cells containing HCV sub-genomic repliconMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176475(((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataIC50: 50nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187218((S)-1-(3,4,5-trichloro-2-hydroxyphenylsulfonyl)pyr...)
Affinity DataIC50: 80nMAssay Description:Cytotoxicity against human Huh7 cell line containing HCV genotype 1b repliconMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150374(2-[(2-Bromo-6-methoxy-5-trifluoromethyl-naphthalen...)
Affinity DataIC50: 120nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176486((5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H...)
Affinity DataIC50: 130nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176480((5,8-dichloro-1-propyl-3,4-dihydro-1H-benzo[4,5]th...)
Affinity DataIC50: 140nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176488(((R)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benz...)
Affinity DataIC50: 170nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176479((5-bromo-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...)
Affinity DataIC50: 190nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187221((4S)-3-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1,...)
Affinity DataIC50: 240nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187232((S)-1-(3-bromo-5-chloro-2-hydroxyphenylsulfonyl)py...)
Affinity DataIC50: 260nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176476((5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...)
Affinity DataIC50: 320nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150385(2-[(6-Methoxy-5-trifluoromethyl-naphthalene-1-carb...)
Affinity DataIC50: 490nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071561(3-Hydroxy-4-{(2S,3S)-3-methyl-2-[2-(naphthalen-2-y...)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187217(2,4-dichloro-6-{[(2S)-2-(2H-tetrazol-5-yl)pyrrolid...)
Affinity DataIC50: 560nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157734(2-(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyr...)
Affinity DataIC50: 570nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150365(2-[(5-Bromo-6-methoxy-naphthalene-1-carbonyl)-amin...)
Affinity DataIC50: 590nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176483((1-butyl-5,8-dichloro-3,4-dihydro-1H-benzo[4,5]thi...)
Affinity DataIC50: 750nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187228((S)-1-(3,5-dichloro-2-hydroxyphenylsulfonyl)pyrrol...)
Affinity DataIC50: 770nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150370([Carboxymethyl-(6-methoxy-5-trifluoromethyl-naphth...)
Affinity DataIC50: 900nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150368(2-[(2-Bromo-6-methoxy-5-trifluoromethyl-naphthalen...)
Affinity DataIC50: 910nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150375(2-[(5-Bromo-6-methoxy-naphthalene-1-carbonyl)-amin...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182775(3-allyl-5,8-dichloro-1,2,3,4-tetrahydrocyclopenta[...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071556(N-[(1S,2S)-1-(1-Benzyl-3-butylcarbamoyl-2-hydroxy-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150382(2-[(6-Methoxy-5-trifluoromethyl-naphthalene-1-carb...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150379(2-[(2-Fluoro-6-methoxy-5-trifluoromethyl-naphthale...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150369([(2-Bromo-6-methoxy-5-trifluoromethyl-naphthalene-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187233((2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pyr...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176489((5,8-dichloro-1-propyl-3,4-dihydro-1H-benzo[4,5]fu...)
Affinity DataIC50: 1.49E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182777(3-butyl-8-cyano-7-fluoro-5-methyl-1,2,3,4-tetrahyd...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187224((4R)-3-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1,...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182768(8-cyano-7-fluoro-5-methyl-3-propyl-1,2,3,4-tetrahy...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176481((5,8-dichloro-1-ethyl-3,4-dihydro-1H-benzo[4,5]thi...)
Affinity DataIC50: 1.90E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182788(3-butyl-5,8-dichloro-1,2,3,4-tetrahydrocyclopenta[...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150378([(2-Bromo-6-methoxy-5-trifluoromethyl-naphthalene-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182786(2-(5-cyano-8-fluoro-1-propyl-2,3,4,9-tetrahydro-1H...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187230((2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pip...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150381(2-[(2-Fluoro-6-methoxy-5-trifluoromethyl-naphthale...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182765(2-(5-cyano-8-methyl-1-propyl-2,3,4,9-tetrahydro-1H...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187222((S)-1-(3-chloro-5-fluoro-2-hydroxyphenylsulfonyl)p...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182769(2-(5,8-dicyano-1-propyl-2,3,4,9-tetrahydro-1H-carb...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176485(((S)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benz...)
Affinity DataIC50: 2.85E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150377([(2-Bromo-6-methoxy-5-trifluoromethyl-naphthalene-...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150366([(2-Bromo-6-methoxy-5-trifluoromethyl-naphthalene-...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187225((S)-1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyr...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182785(5,8-dichloro-1-propyl-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150376([Allyloxycarbonyl-(2-bromo-6-methoxy-5-trifluorome...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176482((1-butyl-5,8-dichloro-3,4-dihydro-1H-benzo[4,5]fur...)
Affinity DataIC50: 4.46E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182789(3-butyl-8-cyano-5-methyl-1,2,3,4-tetrahydrocyclope...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182783(8-cyano-5-methyl-3-propyl-1,2,3,4-tetrahydrocyclop...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187229(2,4-dichloro-6-(pyrrolidin-1-ylsulfonyl)phenol | C...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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